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*Compound via MeSH
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*1,25-DIHYDROXYCHOLECALCIFEROL
The Journal of Immunology, 1998, 160: 5314-5319.
Copyright © 1998 by The American Association of Immunologists

1,25-Dihydroxyvitamin D3 Is a Positive Regulator for the Two Anti-Encephalitogenic Cytokines TGF-ß1 and IL-41

Margherita T. Cantorna, William D. Woodward2, Colleen E. Hayes and Hector F. DeLuca3

Department of Biochemistry, University of Wisconsin-Madison, College of Agricultural and Life Sciences, Madison, WI 53706

Previously we demonstrated that 1,25-dihydroxyvitamin D3 blocks the progression of relapsing encephalomyelitis. We now propose that 1,25-dihydroxyvitamin D3 blocks these autoimmune symptoms by stimulating the differentiation and/or function of cells that inhibit the encephalitogenic process. To support this belief, we have found that 1,25-dihydroxyvitamin D3 administration to mice increases IL-4 transcripts by 3- to 25-fold and TGF-ß1 transcripts by 4- to 24-fold. Similarly, IL-4 and TGF-ß1 transcripts were higher in the central nervous system of 1,25-dihydroxyvitamin D3-treated mice compared with controls. The number of cells recoverable from the lymph nodes of 1,25-dihydroxyvitamin D3-treated mice was only 50% that of controls. Overall, 1,25-dihydroxyvitamin D3 treatment causes a net loss in the total number of lymphocytes while the number of IL-4 and TGF-ß1 transcripts increased. The systemic and local increase in the expression of these two anti-inflammatory cytokines by 1,25-dihydroxyvitamin D3 may be responsible for the ability of this drug to block encephalomyelitis.




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