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Department of Immunology, Duke University Medical Center, Durham, NC 27710
Lymphocyte migration into lymphoid organs is regulated by
tissue-specific adhesion molecules such as L-selectin and the
4ß7 integrin. Whether L-selectin
also regulates lymphocyte subset-specific migration into specific
lymphoid tissues was examined in this study by comparing the migration
of CD4+ T cells, CD8+ T cells, and B cells from
L-selectin-deficient and wild-type mice. T cells were the predominant
lymphocyte subset entering PLN, MLN, Peyer’s patches, and spleen
during short term (1-h) migration assays. However, both B cell and
CD4+ and CD8+ T cell entries into PLN, MLN, and
Peyer’s patches were dramatically impaired (73–98%) by loss of
L-selectin. Lymphocyte expression of 4ß7
integrin did not compensate for the loss of L-selectin, since both B
and T cells predominantly migrated into the spleen in the absence of
L-selectin. The more efficient migration of T cells into peripheral
lymphoid tissues relative to that of B cells was partly explained by
the finding that T cells expressed L-selectin at 50 to 100% higher
levels than B cells. In addition, a 50% reduction in L-selectin
expression by lymphocytes from hemizygous L-selectin+/-
mice resulted in a 50 to 70% decrease in short term lymphocyte
migration into peripheral lymphoid tissues relative to that of
wild-type lymphocytes. Thus, the differential migration of T and B
lymphocyte subsets to lymphoid tissues is regulated in part by
subset-specific differences in L-selectin expression levels.
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