| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
The Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104;
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121; and
Department of Legal Medicine, Nara Medical University, Kashihara, Nara, Japan
Previous studies showed that HLA-E was expressed in lymphoblastoid cell line (LCL) 721.221 cells, but surface expression was lacking. To determine the signals controlling surface expression, we constructed a series of hybrid genes using complementary portions derived from the HLA-E and HLA-A2 genes. In this manner, a hybrid of HLA-E was identified, designated AEH, which differed from HLA-E by having the HLA-A2 signal sequence substituting for the HLA-E leader peptide. Transfection of LCL 721.221 cells with AEH induced HLA-E surface expression. Analysis of peptides bound to HLA-E revealed that a nonamer peptide derived from the A2 signal sequence was the predominant peptide bound. LCL 721.221 cells transfected with certain class I genes, including HLA-G, were also sufficient to promote peptide binding and HLA-E surface expression without increasing the level of HLA-E heavy chain synthesis. Peptides bound to HLA-E consisted of nine amino acids, with methionine at position 2 and leucine in the carboxyl-terminal position, and were nearly identical to the leader sequence-derived peptide previously shown to be a predominant peptide bound to the murine Qa-1 Ag. Signal peptides derived from certain HLA-B proteins with threonine in position 2 only marginally up-regulated HLA-E surface expression in .221 cells. An examination of HLA-E peptide binding in the TAP negative cell line .134 indicated that peptide binding to HLA-E was dependent on a functional TAP heterodimer regardless of whether peptide was available in cis, as in the AEH construct, or in trans, as in the class I transfectants of .221 cells.
This article has been cited by other articles:
|
|
 |
|
  S. S. Kalkunte, T. F. Mselle, W. E. Norris, C. R. Wira, C. L. Sentman, and S. Sharma Vascular Endothelial Growth Factor C Facilitates Immune Tolerance and Endovascular Activity of Human Uterine NK Cells at the Maternal-Fetal Interface J. Immunol., April 1, 2009; 182(7): 4085 - 4092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Saez-Borderias, N. Romo, G. Magri, M. Guma, A. Angulo, and M. Lopez-Botet IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C+ NK Cell Function J. Immunol., January 15, 2009; 182(2): 829 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lo Monaco, L. Sibilio, E. Melucci, E. Tremante, M. Suchanek, V. Horejsi, A. Martayan, and P. Giacomini HLA-E: Strong Association with {beta}2-Microglobulin and Surface Expression in the Absence of HLA Class I Signal Sequence-Derived Peptides J. Immunol., October 15, 2008; 181(8): 5442 - 5450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Morel and T. Bellon HLA Class I Molecules Regulate IFN-{gamma} Production Induced in NK Cells by Target Cells, Viral Products, or Immature Dendritic Cells through the Inhibitory Receptor ILT2/CD85j J. Immunol., August 15, 2008; 181(4): 2368 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Martayan, L. Sibilio, A. Setini, E. L. Monaco, E. Tremante, D. Fruci, M. Colonna, and P. Giacomini N-Linked Glycosylation Selectively Regulates the Generic Folding of HLA-Cw1 J. Biol. Chem., June 13, 2008; 283(24): 16469 - 16476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Carosella, B. Favier, N. Rouas-Freiss, P. Moreau, and J. LeMaoult Beyond the increasing complexity of the immunomodulatory HLA-G molecule Blood, May 15, 2008; 111(10): 4862 - 4870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Q. DeGottardi, A. Specht, B. Metcalf, A. Kaur, F. Kirchhoff, and D. T. Evans Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 J. Virol., March 15, 2008; 82(6): 3139 - 3146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sibilio, A. Martayan, A. Setini, E. L. Monaco, E. Tremante, R. H. Butler, and P. Giacomini A Single Bottleneck in HLA-C Assembly J. Biol. Chem., January 18, 2008; 283(3): 1267 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Stern Characterizing MHC-Associated Peptides by Mass Spectrometry J. Immunol., September 1, 2007; 179(5): 2667 - 2668. [Full Text] [PDF]
|
|
|
|
|
|
S. Coupel, A. Moreau, M. Hamidou, V. Horejsi, J.-P. Soulillou, and B. Charreau Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation Blood, April 1, 2007; 109(7): 2806 - 2814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Draghi, A. Pashine, B. Sanjanwala, K. Gendzekhadze, C. Cantoni, D. Cosman, A. Moretta, N. M. Valiante, and P. Parham NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection J. Immunol., March 1, 2007; 178(5): 2688 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Y. Pappworth, E. C. Wang, and M. Rowe The Switch from Latent to Productive Infection in Epstein-Barr Virus-Infected B Cells Is Associated with Sensitization to NK Cell Killing J. Virol., January 15, 2007; 81(2): 474 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Chow, S. Dhanji, J. Cross, P. Johnson, and H.-S. Teh H2-M3-Restricted T Cells Participate in the Priming of Antigen-Specific CD4+ T Cells J. Immunol., October 15, 2006; 177(8): 5098 - 5104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Meresse, S. A. Curran, C. Ciszewski, G. Orbelyan, M. Setty, G. Bhagat, L. Lee, M. Tretiakova, C. Semrad, E. Kistner, et al. Reprogramming of CTLs into natural killer-like cells in celiac disease J. Exp. Med., May 15, 2006; 203(5): 1343 - 1355. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Spaggiari, A. Capobianco, S. Becchetti, M. C. Mingari, and L. Moretta Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation Blood, February 15, 2006; 107(4): 1484 - 1490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Wooden, S. R. Kalb, R. J. Cotter, and M. J. Soloski Cutting Edge: HLA-E Binds a Peptide Derived from the ATP-Binding Cassette Transporter Multidrug Resistance-Associated Protein 7 aSnd Inhibits NK Cell-Mediated Lysis J. Immunol., August 1, 2005; 175(3): 1383 - 1387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Huang, S. Gilfillan, M. Cella, M. J. Miley, O. Lantz, L. Lybarger, D. H. Fremont, and T. H. Hansen Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells J. Biol. Chem., June 3, 2005; 280(22): 21183 - 21193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nguyen, N. Dhedin, J.-P. Vernant, M. Kuentz, A. A. Jijakli, N. Rouas-Freiss, E. D. Carosella, A. Boudifa, P. Debre, and V. Vieillard NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect Blood, May 15, 2005; 105(10): 4135 - 4142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Hunt, M. G. Petroff, R. H. McIntire, and C. Ober HLA-G and immune tolerance in pregnancy FASEB J, May 1, 2005; 19(7): 681 - 693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. K. Kaiser, F. Barahmand-pour, W. Paulsene, S. Medley, D. E. Geraghty, and R. K. Strong Interactions between NKG2x Immunoreceptors and HLA-E Ligands Display Overlapping Affinities and Thermodynamics J. Immunol., March 1, 2005; 174(5): 2878 - 2884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nattermann, H. D. Nischalke, V. Hofmeister, G. Ahlenstiel, H. Zimmermann, L. Leifeld, E. H. Weiss, T. Sauerbruch, and U. Spengler The HLA-A2 Restricted T Cell Epitope HCV Core35-44 Stabilizes HLA-E Expression and Inhibits Cytolysis Mediated by Natural Killer Cells Am. J. Pathol., February 1, 2005; 166(2): 443 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Jinushi, T. Takehara, T. Tatsumi, T. Kanto, T. Miyagi, T. Suzuki, Y. Kanazawa, N. Hiramatsu, and N. Hayashi Negative Regulation of NK Cell Activities by Inhibitory Receptor CD94/NKG2A Leads to Altered NK Cell-Induced Modulation of Dendritic Cell Functions in Chronic Hepatitis C Virus Infection J. Immunol., November 15, 2004; 173(10): 6072 - 6081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Salerno-Goncalves, M. Fernandez-Vina, D. M. Lewinsohn, and M. B. Sztein Identification of a Human HLA-E-Restricted CD8+ T Cell Subset in Volunteers Immunized with Salmonella enterica Serovar Typhi Strain Ty21a Typhoid Vaccine J. Immunol., November 1, 2004; 173(9): 5852 - 5862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dorrschuck, A. Schmidt, E. Schnurer, M. Gluckmann, C. Albrecht, C. Wolfel, V. Lennerz, A. Lifke, C. Di Natale, E. Ranieri, et al. CD8+ cytotoxic T lymphocytes isolated from allogeneic healthy donors recognize HLA class Ia/Ib-associated renal carcinoma antigens with ubiquitous or restricted tissue expression Blood, October 15, 2004; 104(8): 2591 - 2599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Daza-Vamenta, G. Glusman, L. Rowen, B. Guthrie, and D. E. Geraghty Genetic Divergence of the Rhesus Macaque Major Histocompatibility Complex Genome Res., August 1, 2004; 14(8): 1501 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kambayashi, J. R. Kraft-Leavy, J. G. Dauner, B. A. Sullivan, O. Laur, and P. E. Jensen The Nonclassical MHC Class I Molecule Qa-1 Forms Unstable Peptide Complexes J. Immunol., February 1, 2004; 172(3): 1661 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lee and D. E. Geraghty HLA-F Surface Expression on B Cell and Monocyte Cell Lines Is Partially Independent from Tapasin and Completely Independent from TAP J. Immunol., November 15, 2003; 171(10): 5264 - 5271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pietra, C. Romagnani, P. Mazzarino, M. Falco, E. Millo, A. Moretta, L. Moretta, and M. C. Mingari HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes PNAS, September 16, 2003; 100(19): 10896 - 10901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Bland, M. K. Lemberg, A. J. McMichael, B. Martoglio, and V. M. Braud Requirement of the Proteasome for the Trimming of Signal Peptide-derived Epitopes Presented by the Nonclassical Major Histocompatibility Complex Class I Molecule HLA-E J. Biol. Chem., September 5, 2003; 278(36): 33747 - 33752. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Patel, K. C. Quack, J. A. Hill, and D. J. Schust Expression of membrane-bound HLA-G at the maternal-fetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss Mol. Hum. Reprod., September 1, 2003; 9(9): 551 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Miller, D. A. Weber, C. Ibegbu, J. Pohl, J. D. Altman, and P. E. Jensen Analysis of HLA-E Peptide-Binding Specificity and Contact Residues in Bound Peptide Required for Recognition by CD94/NKG2 J. Immunol., August 1, 2003; 171(3): 1369 - 1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ishitani, N. Sageshima, N. Lee, N. Dorofeeva, K. Hatake, H. Marquardt, and D. E. Geraghty Protein Expression and Peptide Binding Suggest Unique and Interacting Functional Roles for HLA-E, F, and G in Maternal-Placental Immune Recognition J. Immunol., August 1, 2003; 171(3): 1376 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Davies, S. Kalb, B. Liang, C. J. Aldrich, F. A. Lemonnier, H. Jiang, R. Cotter, and M. J. Soloski A Peptide from Heat Shock Protein 60 Is the Dominant Peptide Bound To Qa-1 in the Absence of the MHC Class Ia Leader Sequence Peptide Qdm J. Immunol., May 15, 2003; 170(10): 5027 - 5033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Strong, M. A. Holmes, P. Li, L. Braun, N. Lee, and D. E. Geraghty HLA-E Allelic Variants. CORRELATING DIFFERENTIAL EXPRESSION, PEPTIDE AFFINITIES, CRYSTAL STRUCTURES, AND THERMAL STABILITIES J. Biol. Chem., February 7, 2003; 278(7): 5082 - 5090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lenfant, N. Pizzato, S. Liang, C. Davrinche, P. Le Bouteiller, and A. Horuzsko Induction of HLA-G-restricted human cytomegalovirus pp65 (UL83)-specific cytotoxic T lymphocytes in HLA-G transgenic mice J. Gen. Virol., January 1, 2003; 84(2): 307 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Heinzel, J. E. Grotzke, R. A. Lines, D. A. Lewinsohn, A. L. McNabb, D. N. Streblow, V. M. Braud, H. J. Grieser, J. T. Belisle, and D. M. Lewinsohn HLA-E-dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells J. Exp. Med., December 2, 2002; 196(11): 1473 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Spaggiari, P. Contini, A. Dondero, R. Carosio, F. Puppo, F. Indiveri, M. R. Zocchi, and A. Poggi Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction Blood, December 1, 2002; 100(12): 4098 - 4107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Kang and P. Cresswell Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain J. Biol. Chem., November 15, 2002; 277(47): 44838 - 44844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Drukker, G. Katz, A. Urbach, M. Schuldiner, G. Markel, J. Itskovitz-Eldor, B. Reubinoff, O. Mandelboim, and N. Benvenisty Characterization of the expression of MHC proteins in human embryonic stem cells PNAS, July 23, 2002; 99(15): 9864 - 9869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. C. Y. Wang, B. McSharry, C. Retiere, P. Tomasec, S. Williams, L. K. Borysiewicz, V. M. Braud, and G. W. G. Wilkinson From the Cover: UL40-mediated NK evasion during productive infection with human cytomegalovirus PNAS, May 28, 2002; 99(11): 7570 - 7575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dulphy, C. Rabian, C. Douay, O. Flinois, S. Laoussadi, J. Kuipers, R. Tamouza, D. Charron, and A. Toubert Functional modulation of expanded CD8+ synovial fluid T cells by NK cell receptor expression in HLA-B27-associated reactive arthritis Int. Immunol., May 1, 2002; 14(5): 471 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M. Emmer, E. A.P. Steegers, H. M.J. Kerstens, J. Bulten, W. L.D.M. Nelen, K. Boer, and I. Joosten Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies Hum. Reprod., April 1, 2002; 17(4): 1072 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sharland, A. Patel, J. H. Lee, A. E. Cestra, S. Saidman, and G. L. Waneck Genetically Modified HLA Class I Molecules Able to Inhibit Human NK Cells Without Provoking Alloreactive CD8+ CTLs J. Immunol., April 1, 2002; 168(7): 3266 - 3274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Barakonyi, K. T. Kovacs, E. Miko, L. Szereday, P. Varga, and J. Szekeres-Bartho Recognition of Nonclassical HLA Class I Antigens by {gamma}{delta} T Cells During Pregnancy J. Immunol., March 15, 2002; 168(6): 2683 - 2688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Lemberg, F. A. Bland, A. Weihofen, V. M. Braud, and B. Martoglio Intramembrane Proteolysis of Signal Peptides: An Essential Step in the Generation of HLA-E Epitopes J. Immunol., December 1, 2001; 167(11): 6441 - 6446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Forte, L. Pazmany, U. B. Matter-Reissmann, G. Stussi, M. K. J. Schneider, and J. D. Seebach HLA-G Inhibits Rolling Adhesion of Activated Human NK Cells on Porcine Endothelial Cells J. Immunol., November 15, 2001; 167(10): 6002 - 6008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Li, I. Goldstein, E. Glickman-Nir, H. Jiang, and L. Chess Induction of TCR V{beta}-Specific CD8+ CTLs by TCR V{beta}-Derived Peptides Bound to HLA-E J. Immunol., October 1, 2001; 167(7): 3800 - 3808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Afanassieff, R. M. Goto, J. Ha, M. A. Sherman, L. Zhong, C. Auffray, F. Coudert, R. Zoorob, and M. M. Miller At Least One Class I Gene in Restriction Fragment Pattern-Y (Rfp-Y), the Second MHC Gene Cluster in the Chicken, Is Transcribed, Polymorphic, and Shows Divergent Specialization in Antigen Binding Region J. Immunol., March 1, 2001; 166(5): 3324 - 3333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kanai, T. Fujii, S. Kozuma, T. Yamashita, A. Miki, A. Kikuchi, and Y. Taketani Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture Mol. Hum. Reprod., February 1, 2001; 7(2): 195 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Riteau, C. Menier, I. Khalil-Daher, S. Martinozzi, M. Pla, J. Dausset, E. D. Carosella, and N. Rouas-Freiss HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition Int. Immunol., February 1, 2001; 13(2): 193 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bai, C. J. Aldrich, and J. Forman Factors Controlling the Trafficking and Processing of a Leader-Derived Peptide Presented by Qa-1 J. Immunol., December 15, 2000; 165(12): 7025 - 7034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Kraft, R. E. Vance, J. Pohl, A. M. Martin, D. H. Raulet, and P. E. Jensen Analysis of Qa-1bPeptide Binding Specificity and the Capacity of Cd94/Nkg2a to Discriminate between Qa-1-Peptide Complexes J. Exp. Med., September 5, 2000; 192(5): 613 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Soloski, M. E. Szperka, A. Davies, and S. L. Wooden Host Immune Response to Intracellular Bacteria: A Role for MHC-Linked Class-Ib Antigen-Presenting Molecules Experimental Biology and Medicine, September 1, 2000; 224(4): 231 - 239. [Abstract] [Full Text]
|
|
|
|
|
|
E. Backman-Petersson, G. W. Butcher, and G. Hedlund Self-MHC class Ia (RT1-An) protects cells co-expressing the activatory allogeneic MHC class Ib molecule (RT1-Eu) from NK lysis Int. Immunol., June 1, 2000; 12(6): 843 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ulbrecht, S. Martinozzi, M. Grzeschik, H. Hengel, J. W. Ellwart, M. Pla, and E. H. Weiss Cutting Edge: The Human Cytomegalovirus UL40 Gene Product Contains a Ligand for HLA-E and Prevents NK Cell-Mediated Lysis J. Immunol., May 15, 2000; 164(10): 5019 - 5022. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Tomasec, V. M. Braud, C. Rickards, M. B. Powell, B. P. McSharry, S. Gadola, V. Cerundolo, L. K. Borysiewicz, A. J. McMichael, and G. W. Wilkinson Surface Expression of HLA-E, an Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40 Science, February 11, 2000; 287(5455): 1031 - 1033. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Jun, E. Kim, M. Jin, H. C. Sung, H. Han, D. E. Geraghty, and K. Ahn Human Cytomegalovirus Gene Products US3 and US6 Down-Regulate Trophoblast Class I MHC Molecules J. Immunol., January 15, 2000; 164(2): 805 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Wainwright, P. A. Biro, and C. H. Holmes HLA-F Is a Predominantly Empty, Intracellular, TAP-Associated MHC Class Ib Protein with a Restricted Expression Pattern J. Immunol., January 1, 2000; 164(1): 319 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Vance, A. M. Jamieson, and D. H. Raulet Recognition of the Class Ib Molecule Qa-1b by Putative Activating Receptors Cd94/Nkg2c and Cd94/Nkg2e on Mouse Natural Killer Cells J. Exp. Med., December 20, 1999; 190(12): 1801 - 1812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Palmieri, V. Tullio, A. Zingoni, M. Piccoli, L. Frati, M. Lopez-Botet, and A. Santoni CD94/NKG2-A Inhibitory Complex Blocks CD16-Triggered Syk and Extracellular Regulated Kinase Activation, Leading to Cytotoxic Function of Human NK Cells J. Immunol., June 15, 1999; 162(12): 7181 - 7188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Martinozzi, R. Pacasova, H.-J. Boulouis, M. Ulbrecht, E. H. Weiss, F. Sigaux, and M. Pla Cutting Edge: Requirement of Class I Signal Sequence-Derived Peptides for HLA-E Recognition by a Mouse Cytotoxic T Cell Clone J. Immunol., May 15, 1999; 162(10): 5662 - 5665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Lanier Natural killer cells fertile with receptors for HLA-G? PNAS, May 11, 1999; 96(10): 5343 - 5345. [Full Text] [PDF]
|
|
|
|
|
|
R. Pacasova, S. Martinozzi, H.-J. Boulouis, M. Ulbrecht, J.-C. Vieville, F. Sigaux, E. H. Weiss, and M. Pla Cell-Surface Expression and Alloantigenic Function of a Human Nonclassical Class I Molecule (HLA-E) in Transgenic Mice J. Immunol., May 1, 1999; 162(9): 5190 - 5196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-F. Lo, H. Ong, E. S. Metcalf, and M. J. Soloski T Cell Responses to Gram-Negative Intracellular Bacterial Pathogens: A Role for CD8+ T Cells in Immunity to Salmonella Infection and the Involvement of MHC Class Ib Molecules J. Immunol., May 1, 1999; 162(9): 5398 - 5406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rajagopalan and E. O. Long A Human Histocompatibility Leukocyte Antigen (HLA)-G-specific Receptor Expressed on All Natural Killer Cells J. Exp. Med., April 5, 1999; 189(7): 1093 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S.J. Allan, M. Colonna, L. L. Lanier, T. D. Churakova, J. S. Abrams, S. A. Ellis, A. J. McMichael, and V. M. Braud Tetrameric Complexes of Human Histocompatibility Leukocyte Antigen (HLA)-G Bind to Peripheral Blood Myelomonocytic Cells J. Exp. Med., April 5, 1999; 189(7): 1149 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Vance, J. R. Kraft, J. D. Altman, P. E. Jensen, and D. H. Raulet Mouse CD94/NKG2A Is a Natural Killer Cell Receptor for the Nonclassical Major Histocompatibility Complex (MHC) Class I Molecule Qa-1b J. Exp. Med., November 16, 1998; 188(10): 1841 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Vugmeyster, R. Glas, B. Perarnau, F. A. Lemonnier, H. Eisen, and H. Ploegh Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells PNAS, October 13, 1998; 95(21): 12492 - 12497. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
