| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
The Picower Institute for Medical Research, Laboratory of Medical Biochemistry, Manhasset, NY 11030; and
Case Western Reserve University, Department of Molecular Biology and Microbiology, Cleveland, OH 44106
We recently described a novel population of blood-borne cells,
termed fibrocytes, that display a distinct cell surface phenotype
(collagen+/CD13+/CD34+/CD45+),
rapidly enter sites of tissue injury, and contribute to scar formation.
To further characterize the role of these cells in vivo, we examined
the expression of type I collagen and cytokine mRNAs by cells isolated
from wound chambers implanted into mice. Five days after chamber
implantation, CD34+ fibrocytes but not CD14+
monocytes or CD90+ T cells expressed mRNA for type I
collagen. Fibrocytes purified from wound chambers also were found to
express mRNA for IL-1ß, IL-10, TNF-
, JE/MCP, MIP-1, MIP-1ß,
MIP-2, PDGF-A, TGF-ß1, and M-CSF. The addition of IL-1ß (1–100
ng/ml), a critical mediator in wound healing, to fibrocytes isolated
from human peripheral blood induced the secretion of chemokines
(MIP-1, MIP-1ß, MCP-1, IL-8, and GRO), hemopoietic growth
factors (IL-6, IL-10, and macrophage-CSF), and the fibrogenic cytokine
TNF-. By contrast, IL-1ß decreased the constitutive secretion of
type I collagen as measured by ELISA. Additional evidence for a role
for fibrocytes in collagen production in vivo was obtained in studies
of livers obtained from Schistosoma japonicum-infected
mice. Mouse fibrocytes localized to areas of granuloma formation and
connective matrix deposition. We conclude that fibrocytes are an
important source of cytokines and type I collagen during both the
inflammatory and the repair phase of the wound healing response.
Furthermore, IL-1ß may act on fibrocytes to effect a phenotypic
transition between a repair/remodeling and a proinflammatory mode.
This article has been cited by other articles:
|
|
 |
|
  R. M. Strieter, E. C. Keeley, M. A. Hughes, M. D. Burdick, and B. Mehrad The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis J. Leukoc. Biol., November 1, 2009; 86(5): 1111 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Galligan, K. A. Siminovitch, E. C. Keystone, V. Bykerk, O. D. Perez, and E. N. Fish Fibrocyte activation in rheumatoid arthritis Rheumatology, October 25, 2009; (2009) kep265v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Niedermeier, B. Reich, M. R. Gomez, A. Denzel, K. Schmidbauer, N. Gobel, Y. Talke, F. Schweda, and M. Mack CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes PNAS, October 20, 2009; 106(42): 17892 - 17897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Moore Fibrocytes as Potential Biomarkers in Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., April 1, 2009; 179(7): 524 - 525. [Full Text] [PDF]
|
|
|
|
 |
|
 A M A. El-Asrar, S Struyf, J Van Damme, and K Geboes Circulating fibrocytes contribute to the myofibroblast population in proliferative vitreoretinopathy epiretinal membranes Br J Ophthalmol, May 1, 2008; 92(5): 699 - 704. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Henderson, A. C. Mackinnon, S. L. Farnworth, T. Kipari, C. Haslett, J. P. Iredale, F.-T. Liu, J. Hughes, and T. Sethi Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis Am. J. Pathol., February 1, 2008; 172(2): 288 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Murphy, R. Summer, and A. Fine Stem Cells in Airway Smooth Muscle: State of the Art Proceedings of the ATS, January 1, 2008; 5(1): 11 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Vannella, T. R. McMillan, R. P. Charbeneau, C. A. Wilke, P. E. Thomas, G. B. Toews, M. Peters-Golden, and B. B. Moore Cysteinyl Leukotrienes Are Autocrine and Paracrine Regulators of Fibrocyte Function J. Immunol., December 1, 2007; 179(11): 7883 - 7890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Collard, B. B. Moore, K. R. Flaherty, K. K. Brown, R. J. Kaner, T. E. King Jr., J. A. Lasky, J. E. Loyd, I. Noth, M. A. Olman, et al. Acute Exacerbations of Idiopathic Pulmonary Fibrosis Am. J. Respir. Crit. Care Med., October 1, 2007; 176(7): 636 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Medina, R. T. Kilani, N. Carr, E. Brown, and A. Ghahary Transdifferentiation of Peripheral Blood Mononuclear Cells into Epithelial-Like Cells Am. J. Pathol., October 1, 2007; 171(4): 1140 - 1152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pilling, D. Roife, M. Wang, S. D. Ronkainen, J. R. Crawford, E. L. Travis, and R. H. Gomer Reduction of Bleomycin-Induced Pulmonary Fibrosis by Serum Amyloid P J. Immunol., September 15, 2007; 179(6): 4035 - 4044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Gomperts and R. M. Strieter Fibrocytes in lung disease J. Leukoc. Biol., September 1, 2007; 82(3): 449 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Hong, J. A. Belperio, M. P. Keane, M. D. Burdick, and R. M. Strieter Differentiation of Human Circulating Fibrocytes as Mediated by Transforming Growth Factor-beta and Peroxisome Proliferator-activated Receptor {gamma} J. Biol. Chem., August 3, 2007; 282(31): 22910 - 22920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ishida, A. Kimura, T. Kondo, T. Hayashi, M. Ueno, N. Takakura, K. Matsushima, and N. Mukaida Essential Roles of the CC Chemokine Ligand 3-CC Chemokine Receptor 5 Axis in Bleomycin-Induced Pulmonary Fibrosis through Regulation of Macrophage and Fibrocyte Infiltration Am. J. Pathol., March 1, 2007; 170(3): 843 - 854. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sakai, T. Wada, H. Yokoyama, M. Lipp, S. Ueha, K. Matsushima, and S. Kaneko Secondary lymphoid tissue chemokine (SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis PNAS, September 19, 2006; 103(38): 14098 - 14103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Moore, L. Murray, A. Das, C. A. Wilke, A. B. Herrygers, and G. B. Toews The Role of CCL12 in the Recruitment of Fibrocytes and Lung Fibrosis Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 175 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pilling, N. M. Tucker, and R. H. Gomer Aggregated IgG inhibits the differentiation of human fibrocytes J. Leukoc. Biol., June 1, 2006; 79(6): 1242 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Balmelli, N. Ruggli, K. McCullough, and A. Summerfield Fibrocytes are potent stimulators of anti-virus cytotoxic T cells J. Leukoc. Biol., June 1, 2005; 77(6): 923 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. B. Moore, J. E. Kolodsick, V. J. Thannickal, K. Cooke, T. A. Moore, C. Hogaboam, C. A. Wilke, and G. B. Toews CCR2-Mediated Recruitment of Fibrocytes to the Alveolar Space after Fibrotic Injury Am. J. Pathol., March 1, 2005; 166(3): 675 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Stavitsky Regulation of Granulomatous Inflammation in Experimental Models of Schistosomiasis Infect. Immun., January 1, 2004; 72(1): 1 - 12. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Schuler, S. Kornig, and T. Blankenstein Tumor Rejection by Modulation of Tumor Stromal Fibroblasts J. Exp. Med., November 17, 2003; 198(10): 1487 - 1493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pilling, C. D. Buckley, M. Salmon, and R. H. Gomer Inhibition of Fibrocyte Differentiation by Serum Amyloid P J. Immunol., November 15, 2003; 171(10): 5537 - 5546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kimatrai, C. Oliver, A. C. Abadia-Molina, J. M. Garcia-Pacheco, and E. G. Olivares Contractile Activity of Human Decidual Stromal Cells J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 844 - 849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wu, C. Metz, X. Xu, R. Abe, A. W. Gibson, J. C. Edberg, J. Cooke, F. Xie, G. S. Cooper, and R. P. Kimberly A Novel Polymorphic CAAT/Enhancer-Binding Protein {beta} Element in the FasL Gene Promoter Alters Fas Ligand Expression: A Candidate Background Gene in African American Systemic Lupus Erythematosus Patients J. Immunol., January 1, 2003; 170(1): 132 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Nakayama, H Enzan, E Miyazaki, and M Toi {alpha} Smooth muscle actin positive stromal cells in gastric carcinoma J. Clin. Pathol., October 1, 2002; 55(10): 741 - 744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Gerszten Pleiotropic Effects of Chemokines in Vascular Lesion Development Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 528 - 529. [Full Text] [PDF]
|
|
|
|
 |
|
 I. HARTLAPP, R. ABE, R. W. SAEED, T. PENG, W. VOELTER, R. BUCALA, and C. N. METZ Fibrocytes induce an angiogenic phenotype in cultured endothelial cells and promote angiogenesis in vivo FASEB J, October 1, 2001; 15(12): 2215 - 2224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hirohata, T. Yanagida, T. Nagai, T. Sawada, H. Nakamura, S.'i. Yoshino, T. Tomita, and T. Ochi Induction of fibroblast-like cells from CD34+ progenitor cells of the bone marrow in rheumatoid arthritis J. Leukoc. Biol., September 1, 2001; 70(3): 413 - 421. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Abe, S. C. Donnelly, T. Peng, R. Bucala, and C. N. Metz Peripheral Blood Fibrocytes: Differentiation Pathway and Migration to Wound Sites J. Immunol., June 15, 2001; 166(12): 7556 - 7562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Ogawa, K. Yamazaki, M. Kuwana, Y. Mashima, Y. Nakamura, S. Ishida, I. Toda, Y. Oguchi, K. Tsubota, S. Okamoto, et al. A Significant Role of Stromal Fibroblasts in Rapidly Progressive Dry Eye in Patients with Chronic GVHD Invest. Ophthalmol. Vis. Sci., January 1, 2001; 42(1): 111 - 119. [Abstract] [Full Text]
|
|
|
|
|
|
G. Majno Chronic Inflammation : Links with Angiogenesis and Wound Healing Am. J. Pathol., October 1, 1998; 153(4): 1035 - 1039. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
