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Laboratorio di Biologia Cellulare, Dipartimento di Genetica, Biologia e Chimica Medica, Università di Torino, Torino, Italy;
Istituto Superiore di Sanità, Roma, Italy;
Institute of Immunology-VIRCC, University of Vienna, Vienna, Austria;
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Istituto di Medicina Interna, Università di Torino, Torino, Italy;
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Dipartimento di Scienze Mediche, Università di Torino a Novara, Novara, Italy;
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Istituto di Biologia e Genetica, Università di Ancona, Ancona, Italy
Human CD38 is a cell surface molecule involved in the regulation of lymphocyte adhesion to endothelial cells. This suggests that HUVEC bear a ligand(s) for CD38 on the cell surface. By means of the mAb Moon-1, which specifically inhibits CD38-mediated cell adhesion, we have identified a trans-membrane 130-kDa molecule acting as a ligand for CD38. Here, we report that the molecule recognized by the Moon-1 mAb is CD31, a member of the Ig superfamily. This conclusion is based on 1) cross-inhibition assays between Moon-1 and reference anti-CD31 mAbs; 2) sequential immunoprecipitation experiments using Moon-1 and known anti-CD31 mAbs, and 3) reactivity of the Moon-1 mAb with CD31 transfectants. Further, CD31 and CD38 cognate interactions were found to modulate heterotypic adhesion as well as to implement cytoplasmic calcium fluxes identical to those obtained by means of agonistic anti-CD38 mAbs. Other effects tested included the synthesis of messages for a panel of cytokines, markedly increased upon receptor-ligand interactions. These results suggest that the interplay between CD38 and its ligand CD31 is an important step in the regulation of cell life and of the migration of leukocytes (and CD38+ cancer cells) through the endothelial cell wall.
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M. Cicmil, J. M. Thomas, M. Leduc, C. Bon, and J. M. Gibbins Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets Blood, January 1, 2002; 99(1): 137 - 144. [Abstract] [Full Text] [PDF]
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S. Ibrahim, M. Keating, K.-A. Do, S. O'Brien, Y. O. Huh, I. Jilani, S. Lerner, H. M. Kantarjian, and M. Albitar CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia Blood, July 1, 2001; 98(1): 181 - 186. [Abstract] [Full Text] [PDF]
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T. Musso, S. Deaglio, L. Franco, L. Calosso, R. Badolato, G. Garbarino, U. Dianzani, and F. Malavasi CD38 expression and functional activities are up-regulated by IFN-{gamma} on human monocytes and monocytic cell lines J. Leukoc. Biol., April 1, 2001; 69(4): 605 - 612. [Abstract] [Full Text]
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R. Mallone, A. Funaro, M. Zubiaur, G. Baj, C. M. Ausiello, C. Tacchetti, J. Sancho, C. Grossi, and F. Malavasi Signaling through CD38 induces NK cell activation Int. Immunol., April 1, 2001; 13(4): 397 - 409. [Abstract] [Full Text] [PDF]
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R. D. Thompson, K. E. Noble, K. Y. Larbi, A. Dewar, G. S. Duncan, T. W. Mak, and S. Nourshargh Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane Blood, March 15, 2001; 97(6): 1854 - 1860. [Abstract] [Full Text] [PDF]
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E. Prager, G. Staffler, O. Majdic, M. D. Saemann, S. Godar, G. J. Zlabinger, and H. Stockinger Induction of Hyporesponsiveness and Impaired T Lymphocyte Activation by the CD31 Receptor:Ligand Pathway in T Cells J. Immunol., February 15, 2001; 166(4): 2364 - 2371. [Abstract] [Full Text] [PDF]
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 N. Sheibani, C. M. Sorenson, and W. A. Frazier Differential Modulation of Cadherin-mediated Cell-Cell Adhesion by Platelet Endothelial Cell Adhesion Molecule-1 Isoforms through Activation of Extracellular Regulated Kinases Mol. Biol. Cell, August 1, 2000; 11(8): 2793 - 2802. [Abstract] [Full Text]
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R. D. Thompson, M. W. Wakelin, K. Y. Larbi, A. Dewar, G. Asimakopoulos, M. A. Horton, M. T. Nakada, and S. Nourshargh Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and {beta}3 Integrin Blockade on Leukocyte Transmigration In Vivo J. Immunol., July 1, 2000; 165(1): 426 - 434. [Abstract] [Full Text] [PDF]
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L. M. Botella, A. Puig-Kroger, N. Almendro, T. Sanchez-Elsner, E. Munoz, A. Corbi, and C. Bernabeu Identification of a Functional NF-{kappa}B Site in the Platelet Endothelial Cell Adhesion Molecule-1 Promoter J. Immunol., February 1, 2000; 164(3): 1372 - 1378. [Abstract] [Full Text] [PDF]
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E. Todisco, T. Suzuki, K. Srivannaboon, E. Coustan-Smith, S. C. Raimondi, F. G. Behm, A. Kitanaka, and D. Campana CD38 ligation inhibits normal and leukemic myelopoiesis Blood, January 15, 2000; 95(2): 535 - 542. [Abstract] [Full Text] [PDF]
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M. T. Nakada, K. Amin, M. Christofidou-Solomidou, C. D. O'Brien, J. Sun, I. Gurubhagavatula, G. A. Heavner, A. H. Taylor, C. Paddock, Q.-H. Sun, et al. Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment J. Immunol., January 1, 2000; 164(1): 452 - 462. [Abstract] [Full Text] [PDF]
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G. Sconocchia, J. A. Titus, A. Mazzoni, A. Visintin, F. Pericle, S. W. Hicks, F. Malavasi, and D. M. Segal CD38 Triggers Cytotoxic Responses in Activated Human Natural Killer Cells Blood, December 1, 1999; 94(11): 3864 - 3871. [Abstract] [Full Text] [PDF]
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G. Nicoll, J. Ni, D. Liu, P. Klenerman, J. Munday, S. Dubock, M.-G. Mattei, and P. R. Crocker Identification and Characterization of a Novel Siglec, Siglec-7, Expressed by Human Natural Killer Cells and Monocytes J. Biol. Chem., November 26, 1999; 274(48): 34089 - 34095. [Abstract] [Full Text] [PDF]
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 L. Sun, O. A. Adebanjo, B. S. Moonga, S. Corisdeo, H. K. Anandatheerthavarada, G. Biswas, T. Arakawa, Y. Hakeda, A. Koval, B. Sodam, et al. CD38/ADP-Ribosyl Cyclase: A New Role in the Regulation of Osteoclastic Bone Resorption J. Cell Biol., September 6, 1999; 146(5): 1161 - 1172. [Abstract] [Full Text] [PDF]
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R. Chiba, N. Nakagawa, K. Kurasawa, Y. Tanaka, Y. Saito, and I. Iwamoto Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells Blood, August 15, 1999; 94(4): 1319 - 1329. [Abstract] [Full Text] [PDF]
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M. Zubiaur, M. Guirado, C. Terhorst, F. Malavasi, and J. Sancho The CD3-gamma delta epsilon Transducing Module Mediates CD38-induced Protein-tyrosine Kinase and Mitogen-activated Protein Kinase Activation in Jurkat T Cells J. Biol. Chem., July 16, 1999; 274(29): 20633 - 20642. [Abstract] [Full Text] [PDF]
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D. Kempuraj, H. Saito, A. Kaneko, K. Fukagawa, M. Nakayama, H. Toru, M. Tomikawa, H. Tachimoto, M. Ebisawa, A. Akasawa, et al. Characterization of Mast Cell-Committed Progenitors Present in Human Umbilical Cord Blood Blood, May 15, 1999; 93(10): 3338 - 3346. [Abstract] [Full Text] [PDF]
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A. Kitanaka, T. Suzuki, C. Ito, H. Nishigaki, E. Coustan-Smith, T. Tanaka, Y. Kubota, and D. Campana CD38-Mediated Signaling Events in Murine Pro-B Cells Expressing Human CD38 With or Without Its Cytoplasmic Domain J. Immunol., February 15, 1999; 162(4): 1952 - 1958. [Abstract] [Full Text] [PDF]
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M. Konopleva, Z. Estrov, S. Zhao, M. Andreeff, and K. Mehta Ligation of Cell Surface CD38 Protein with Agonistic Monoclonal Antibody Induces a Cell Growth Signal in Myeloid Leukemia Cells J. Immunol., November 1, 1998; 161(9): 4702 - 4708. [Abstract] [Full Text] [PDF]
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M. Morra, M. Zubiaur, C. Terhorst, J. Sancho, and F. Malavasi CD38 is functionally dependent on the TCR/CD3 complex in human T cells FASEB J, May 1, 1998; 12(7): 581 - 592. [Abstract] [Full Text]
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A. Funaro, M. Reinis, O. Trubiani, S. Santi, R. Di Primio, and F. Malavasi CD38 Functions Are Regulated Through an Internalization Step J. Immunol., March 1, 1998; 160(5): 2238 - 2247. [Abstract] [Full Text] [PDF]
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M. Cicmil, J. M. Thomas, T. Sage, F. A. Barry, M. Leduc, C. Bon, and J. M. Gibbins Collagen, Convulxin, and Thrombin Stimulate Aggregation-independent Tyrosine Phosphorylation of CD31 in Platelets. EVIDENCE FOR THE INVOLVEMENT OF Src FAMILY KINASES J. Biol. Chem., August 25, 2000; 275(35): 27339 - 27347. [Abstract] [Full Text] [PDF]
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M. Zubiaur, O. Fernandez, E. Ferrero, J. Salmeron, B. Malissen, F. Malavasi, and J. Sancho CD38 Is Associated with Lipid Rafts and upon Receptor Stimulation Leads to Akt/Protein Kinase B and Erk Activation in the Absence of the CD3-zeta Immune Receptor Tyrosine-based Activation Motifs J. Biol. Chem., January 4, 2002; 277(1): 13 - 22. [Abstract] [Full Text] [PDF]
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 M.-T. Zilber, S. Gregory, R. Mallone, S. Deaglio, F. Malavasi, D. Charron, and C. Gelin CD38 expressed on human monocytes: A coaccessory molecule in the superantigen-induced proliferation PNAS, March 14, 2000; 97(6): 2840 - 2845. [Abstract] [Full Text] [PDF]
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 G. Cao, C. D. O'Brien, Z. Zhou, S. M. Sanders, J. N. Greenbaum, A. Makrigiannakis, and H. M. DeLisser Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1181 - C1190. [Abstract] [Full Text] [PDF]
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