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*
McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada;
University of Houston, Houston, TX 77204; and
CytoMed, Inc., Cambridge, MA 02139.
The 9804 gene, which encodes a human Ly-6 protein most similar to
mouse differentiation Ag TSA-1/Sca-2, has also been called RIG-E. Like
mouse TSA-1, it has a broad tissue distribution with varied expression
levels in normal human tissues and tumor cell lines. Like some members
of the murine Ly-6 family, the 9804 gene is responsive to IFNs,
particularly IFN-
. Overlapping genomic fragments spanning the 9804
gene (5543 bp) have been isolated and characterized. The gene
organization is analogous to that of known mouse Ly-6 genes. The first
exon, 2296 bp upstream from exon II, is entirely untranslated. The
three coding exons (II, III, and IV) are separated by short introns of
321 and 131 bp, respectively. Primers were developed for specific
amplification of 9804 gene fragments. Screening of human-hamster
somatic cell hybrids and yeast artificial chromosomes (YACs) indicated
that the gene is distal to c-Myc, located in the q arm of
human chromosome 8. No positives were detected from the Centre d'Etude
du Polymorphisme Humain mega-YAC A or B panels, nor from bacterial
artificial chromosome libraries; two positive cosmids (c101F1 and
c157F6) were isolated from a human chromosome 8 cosmid library
(LA08NC01). Fluorescence in situ hybridization of metaphase spreads of
chromosome 8, containing hybrid cell line 706-B6 clone 17 (CL-17) with
cosmid c101F1, placed the 9804 gene close to the telomere at 8q24.3.
This mapping is significant, since the region shares a homology with a
portion of mouse chromosome 15, which extends into band E where Ly-6
genes reside. Moreover, the gene encoding E48, the homologue of mouse
Ly-6 molecule ThB, has also been mapped to 8q24.
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