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CUTTING EDGE |
Department of Immunology, Niigata University School of Medicine, Niigata, Japan;
*
Department of Immunology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan;
Core Research for Evolutional Science and Technology (CREST) of Japan Science and Technology (JST) Corporation, Tokyo, Japan; and
Howard Hughes Medical Institute, Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232
CD1-dependent NK1+ T cells rapidly produce
IL-4 upon stimulation through the TCR. These cells may therefore play
an important role in the initiation of Th2 responses. Here, we show
that NK1+ T cells constitutively express receptors for
IL-12 and IFN-
, and that IL-12 induces production of perforin in
these cells. Moreover, while IL-12 induces high levels of IFN- and
cytotoxic activity of hepatic or splenic mononuclear cells against
tumor cells, this effect of IL-12 is significantly reduced in
CD1-deficient mice with impaired NK1+ T cells development.
These results indicate that NK1+ T cells play a critical
role in IL-12-induced production of IFN- to initiate Th1 immune
responses and as IL-12-induced cytotoxic effector cells to initiate
antitumor immunity.
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M. J. Smyth, K. Y. T. Thia, S. E.A. Street, E. Cretney, J. A. Trapani, M. Taniguchi, T. Kawano, S. B. Pelikan, N. Y. Crowe, and D. I. Godfrey Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells J. Exp. Med., February 21, 2000; 191(4): 661 - 668. [Abstract] [Full Text] [PDF]
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S. Pied, J. Roland, A. Louise, D. Voegtle, V. Soulard, D. Mazier, and P.-A. Cazenave Liver CD4-CD8- NK1.1+ TCR{alpha}{beta} Intermediate Cells Increase During Experimental Malaria Infection and Are Able to Exhibit Inhibitory Activity Against the Parasite Liver Stage In Vitro J. Immunol., February 1, 2000; 164(3): 1463 - 1469. [Abstract] [Full Text] [PDF]
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D. K. Thibodeaux, S. E. Hunter, K. E. Waldburger, J. L. Bliss, W. L. Trepicchio, J. P. Sypek, K. Dunussi-Joannopoulos, S. J. Goldman, and J. P. Leonard Autocrine Regulation of IL-12 Receptor Expression Is Independent of Secondary IFN-{gamma} Secretion and not Restricted to T and NK Cells J. Immunol., November 15, 1999; 163(10): 5257 - 5264. [Abstract] [Full Text] [PDF]
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M. Falcone, B. Yeung, L. Tucker, E. Rodriguez, and N. Sarvetnick A Defect in Interleukin 12-Induced Activation and Interferon {gamma} Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-Dependent Diabetes Mellitus J. Exp. Med., October 4, 1999; 190(7): 963 - 972. [Abstract] [Full Text] [PDF]
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Y. Naiki, H. Nishimura, T. Kawano, Y. Tanaka, S. Itohara, M. Taniguchi, and Y. Yoshikai Regulatory Role of Peritoneal NK1.1+{alpha}{beta} T Cells in IL-12 Production During Salmonella Infection J. Immunol., August 15, 1999; 163(4): 2057 - 2063. [Abstract] [Full Text] [PDF]
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W. Hashimoto, T. Osaki, H. Okamura, P. D. Robbins, M. Kurimoto, S. Nagata, M. T. Lotze, and H. Tahara Differential Antitumor Effects of Administration of Recombinant IL-18 or Recombinant IL-12 Are Mediated Primarily by Fas-Fas Ligand- and Perforin-Induced Tumor Apoptosis, Respectively J. Immunol., July 15, 1999; 163(2): 583 - 589. [Abstract] [Full Text] [PDF]
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M. Tomura, W.-G. Yu, H.-J. Ahn, M. Yamashita, Y.-F. Yang, S. Ono, T. Hamaoka, T. Kawano, M. Taniguchi, Y. Koezuka, et al. A Novel Function of V{alpha}14+CD4+NKT Cells: Stimulation of IL-12 Production by Antigen-Presenting Cells in the Innate Immune System J. Immunol., July 1, 1999; 163(1): 93 - 101. [Abstract] [Full Text] [PDF]
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G. Eberl, R. Lees, S. T. Smiley, M. Taniguchi, M. J. Grusby, and H. R. MacDonald Tissue-Specific Segregation of CD1d-Dependent and CD1d-Independent NK T Cells J. Immunol., June 1, 1999; 162(11): 6410 - 6419. [Abstract] [Full Text] [PDF]
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A. R. Satoskar, L. M. Stamm, X. Zhang, A. A. Satoskar, M. Okano, C. Terhorst, J. R. David, and B. Wang Mice Lacking NK Cells Develop an Efficient Th1 Response and Control Cutaneous Leishmania major Infection J. Immunol., June 1, 1999; 162(11): 6747 - 6754. [Abstract] [Full Text] [PDF]
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M. J. Smyth, J. M. Kelly, A. G. Baxter, H. Korner, and J. D. Sedgwick An Essential Role for Tumor Necrosis Factor in Natural Killer Cell-mediated Tumor Rejection in the Peritoneum J. Exp. Med., November 2, 1998; 188(9): 1611 - 1619. [Abstract] [Full Text] [PDF]
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