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Diphtheria Toxin

Importance of Old and New Factors in Its Production

From the Bureau of Laboratories, Health Department, New York City

Abstract

The preparation of diphtheria toxins from the time of its discovery by Behring has been repeatedly investigated with the development of many changes in its preparation, but it still presents many difficulties. The urgent need of strong potent toxins for the Ramon flocculation tests for titration of diphtheria antitoxins, and also for the preparation of toxin-antitoxin mixtures and toxoids for immunization, led the writer at the instigation of Dr. Park to add her attempts to the further solving of this problem. The Ramon flocculation test for titrating toxins was of greatest value in the following studies. It would have been indeed a difficult, tedious and expensive task, to check the numerous lots of toxins prepared by guinea pig instead of the test tube tests. By the Ramon tests, different lots of toxins could be tested on different days of growth and the results known from twenty minutes to twenty-four hours, depending on the strength of the toxin.