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Ricinoleated Vaccines

From the Division of Laboratories and Research, New York State Department of Health, Albany

Abstract

In his recent explanation of the phenomenon of ulceration caused by the injection of sodium-ricinoleate solution into animals, Larson (1) suggested that it is due to the use of barium in the preparation of ricinoleic acid because it is practically impossible to remove traces of barium. As regards the author's recent work (2), however, Larson is not justified in attributing the ulcerative action of the vaccine to that cause. The method of purification of ricinoleic acid which was used and which will appear shortly in the Journal of Bacteriology, insures a preparation of the fatty acid free from barium. Moreover, even if there had been traces of barium in the ricinoleic-acid preparation, which had not been removed by sulfuric acid and repeated extraction of the fatty acid with ether, the minute amounts of that element not detectable by the usual chemical methods would not have been sufficient to cause any irritation of the animal tissues when injected with a 1-per-cent solution of sodium ricinoleate.