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Distribution of Antibodies in the Serum and Organs of Rabbits

IV. Hemolysins and Precipitins

From the Henry Phipps Institute, University of Pennsylvania, Philadelphia

Abstract

Previous work (1) has shown that agglutinins can be recovered from the organs of actively or passively immunized rabbits by extraction with salt solution, and that there is a definite quantitative relation between the antibody content of the serum and that of the organs. The purpose of the present work is to establish whether such a relation holds true for other antibodies.

In the literature on the subject there are several reports on the quantitative relation between the antibody content of the serum and organs of lower animals and man. (a) One group of studies were undertaken to establish the site of antibody-production. In these studies, most of the animals were examined very shortly after the injection of antigen, at a time when presumably the antibody-content of the site of antibody-production is relatively high, i.e., when the final distribution of the antibodies produced has not been reached.