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Distribution of Antibodies in the Serum and Organs of Rabbits

III. Agglutinin Content of the Lymph and Tissue of the Liver and of the Lymph and Muscle of the Leg¹

From the Henry Phipps Institute, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

In a previous study of the distribution of agglutinins in the serum and organs of rabbits (1), it has been shown that the liver, spleen, kidney, lung, uterus and skin of actively or passively immunized rabbits accumulate approximately the same amount of antibodies per gram of organ. A decided difference was observed, however, in the rate of accumulation in these organs. In passively immunized animals the accumulation of agglutinins is rapid in the liver, spleen, kidney and lung. In these organs the accumulation was completed within from ten to fifteen minutes after the immune serum had been injected into the ear vein. On the other hand, in the uterus and particularly in the skin, the accumulation of antibodies continued for several hours.

In the first paper of this series it was suggested that the relatively early appearance of antibodies in the liver, spleen, kidney and lung may be connected with the relatively greater rate of lymph flow from these organs.

Footnotes

¹ Read before the Physiological Society of Philadelphia on April 16, 1928. See Am. J. Med. Sc., 1928, 175, 867.