| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 159, Issue 8 3757-3766, Copyright © 1997 by American Association of Immunologists
ARTICLES |
J Choe, HS Kim, RJ Armitage and YS Choi
Laboratory of Cellular Immunology, Alton Ochsner Medical Foundation, New Orleans, LA 70121, USA.
The germinal center (GC) is an anatomical site where memory B cells are generated. Ag-Ab complexes presented by follicular dendritic cells in GC select precursors of memory B cells. Using a unique in vitro experimental system in which the survival of GC B cells is supported by a defined follicular dendritic cell-like cell line, we investigated the effects of B cell Ag receptor (BCR) stimulation and IL-4 on the memory B cell generation from centroblasts. IL-4 is reported to be critical for GC formation. Centroblasts differentiated to centrocytes during the culture period of 3 days as demonstrated by the down-regulation of CD77 expression and induction of CD44 as well as Bcl-2 expression. The transition of centroblast to centrocyte was enhanced by BCR stimulation and IL-4. Upon further culture, the centrocytes differentiated to memory B cells, a process that was enhanced by BCR stimulation and IL- 4. The presence of IL-4 in the culture did not increase the number of plasma cells. These experimental data provide formal in vitro evidence that Ags in GC may participate not only in the selection but also in the expansion of memory B cells and that IL-4 is a growth factor promoting this expansion.
This article has been cited by other articles:
|
|
 |
|
  I. Y. Lee, W. Cho, J. Kim, C.-S. Park, and J. Choe Human Follicular Dendritic Cells Interact with T Cells via Expression and Regulation of Cyclooxygenases and Prostaglandin E and I Synthases J. Immunol., February 1, 2008; 180(3): 1390 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. C. Kuo, A. L. Shaffer, J. Haddad Jr., Y. S. Choi, L. M. Staudt, and K. Calame Repression of BCL-6 is required for the formation of human memory B cells in vitro J. Exp. Med., April 16, 2007; 204(4): 819 - 830. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Lu, J. Chen, R. T. Sasmono, E. D. Hsi, K. A. Sarosiek, T. Tiganis, and I. S. Lossos T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6 Mol. Cell. Biol., March 15, 2007; 27(6): 2166 - 2179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Jin and T. R. Malek Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21 J. Leukoc. Biol., December 1, 2006; 80(6): 1416 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Y. Lee, E.-M. Ko, S.-H. Kim, D.-I. Jeoung, and J. Choe Human Follicular Dendritic Cells Express Prostacyclin Synthase: A Novel Mechanism to Control T Cell Numbers in the Germinal Center J. Immunol., August 1, 2005; 175(3): 1658 - 1664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Inamine, Y. Takahashi, N. Baba, K. Miyake, T. Tokuhisa, T. Takemori, and R. Abe Two waves of memory B-cell generation in the primary immune response Int. Immunol., May 1, 2005; 17(5): 581 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. S. Lossos, A. A. Alizadeh, R. Rajapaksa, R. Tibshirani, and R. Levy HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma Blood, January 15, 2003; 101(2): 433 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jung, A.-K. Yi, X. Zhang, J. Choe, L. Li, and Y. S. Choi Distinct Response of Human B Cell Subpopulations in Recognition of an Innate Immune Signal, CpG DNA J. Immunol., September 1, 2002; 169(5): 2368 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Johansson-Lindbom and C. A. K. Borrebaeck Germinal Center B Cells Constitute a Predominant Physiological Source of IL-4: Implication for Th2 Development In Vivo J. Immunol., April 1, 2002; 168(7): 3165 - 3172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Uchida, K. Okazaki, A. Debrecceni, T. Nishi, H. Iwano, M. Inai, S. Uose, H. Nakase, M. Ohana, C. Oshima, et al. Analysis of Cytokines in the Early Development of Gastric Secondary Lymphoid Follicles in Helicobacter pylori-Infected BALB/c Mice with Neonatal Thymectomy Infect. Immun., November 1, 2001; 69(11): 6749 - 6754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, L. Li, J. Jung, S. Xiang, C. Hollmann, and Y. S. Choi The Distinct Roles of T Cell-Derived Cytokines and a Novel Follicular Dendritic Cell-Signaling Molecule 8D6 in Germinal Center-B Cell Differentiation J. Immunol., July 1, 2001; 167(1): 49 - 56. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Oshima, K. Okazaki, Y. Matsushima, M. Sawada, T. Chiba, K. Takahashi, H. Hiai, T. Katakai, S. Kasakura, and T. Masuda Induction of Follicular Gastritis following Postthymectomy Autoimmune Gastritis in Helicobacter pylori-Infected BALB/c Mice Infect. Immun., January 1, 2000; 68(1): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Choe, L. Li, X. Zhang, C. D. Gregory, and Y. S. Choi Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055 J. Immunol., January 1, 2000; 164(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gupta, M. Jiang, A. Anthony, and A. B. Pernis Lineage-specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4 J. Exp. Med., December 20, 1999; 190(12): 1837 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Krzysiek, E. A. Lefevre, W. Zou, A. Foussat, J. Bernard, A. Portier, P. Galanaud, and Y. Richard Antigen Receptor Engagement Selectively Induces Macrophage Inflammatory Protein-1{alpha} (MIP-1{alpha}) and MIP-1{beta} Chemokine Production in Human B Cells J. Immunol., April 15, 1999; 162(8): 4455 - 4463. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
