| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 159, Issue 7 3278-3287, Copyright © 1997 by American Association of Immunologists
ARTICLES |
S Sato, AS Miller, MC Howard and TF Tedder
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
B lymphocyte development and function are regulated in part by the CD19 cell surface receptor complex, which is composed of at least four proteins; CD19, CD21 (CR2, complement receptor 2), CD81, and Leu 13. Because this complex has eight membrane-spanning domains and six cytoplasmic regions, determining the molecular basis for its function and signal transduction activities has not been straightforward. In this study, the contribution of the CD19 cytoplasmic domain to the in vivo function of the CD19/CD21/CD81/Leu 13 complex was assessed by generating CD19-deficient mice that expressed a transgene that encoded only the extracellular and transmembrane domains of CD19. Mice expressing this transgene were similar, if not identical, to CD19- deficient mice with abnormal B cell development, a lack of B-1 cells, increased surface IgM levels on B cells, modest mitogen responses, minimal serum Ig levels, and low humoral immune responses. The results of this study indicate that specific signals generated through the cytoplasmic domain of CD19 are essential for B lymphocyte development and function, and that CD19 is the dominant signaling component of the CD19 complex. Moreover, expression of the CD19 cytoplasmic domain is required for optimal signaling through the B cell Ag receptor complex.
This article has been cited by other articles:
|
|
 |
|
  U. C. Lange, D. J. Adams, C. Lee, S. Barton, R. Schneider, A. Bradley, and M. A. Surani Normal Germ Line Establishment in Mice Carrying a Deletion of the Ifitm/Fragilis Gene Family Cluster Mol. Cell. Biol., August 1, 2008; 28(15): 4688 - 4696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. W. Kin and V. M. Sanders CD86 Regulates IgG1 Production via a CD19-Dependent Mechanism J. Immunol., August 1, 2007; 179(3): 1516 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shoham, R. Rajapaksa, C.-C. Kuo, J. Haimovich, and S. Levy Building of the Tetraspanin Web: Distinct Structural Domains of CD81 Function in Different Cellular Compartments Mol. Cell. Biol., February 15, 2006; 26(4): 1373 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Lickert, B. Cox, C. Wehrle, M. M. Taketo, R. Kemler, and J. Rossant Dissecting Wnt/{beta}-catenin signaling during gastrulation using RNA interference in mouse embryos Development, June 1, 2005; 132(11): 2599 - 2609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Diamant, Z. Keren, and D. Melamed CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing Blood, April 15, 2005; 105(8): 3247 - 3254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shoham, R. Rajapaksa, C. Boucheix, E. Rubinstein, J. C. Poe, T. F. Tedder, and S. Levy The Tetraspanin CD81 Regulates the Expression of CD19 During B Cell Development in a Postendoplasmic Reticulum Compartment J. Immunol., October 15, 2003; 171(8): 4062 - 4072. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yasutomo Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus Rheumatology, February 1, 2003; 42(2): 214 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Nielsen and R. G. Q. Leslie Complement's participation in acquired immunity J. Leukoc. Biol., August 1, 2002; 72(2): 249 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, J. C. Poe, A. B. Satterthwaite, M. I. Wahl, O. N. Witte, and T. F. Tedder Complementary Roles for CD19 and Bruton's Tyrosine Kinase in B Lymphocyte Signal Transduction J. Immunol., June 1, 2002; 168(11): 5465 - 5476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shivtiel, N. Leider, O. Sadeh, Z. Kraiem, and D. Melamed Impaired Light Chain Allelic Exclusion and Lack of Positive Selection in Immature B Cells Expressing Incompetent Receptor Deficient of CD19 J. Immunol., June 1, 2002; 168(11): 5596 - 5604. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Pru, K. J. Austin, A. L. Haas, and T. R. Hansen Pregnancy and Interferon-{tau} Upregulate Gene Expression of Members of the 1-8 Family in the Bovine Uterus Biol Reprod, November 1, 2001; 65(5): 1471 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, M. Fujimoto, J. C. Poe, D. A. Steeber, and T. F. Tedder CD19 Can Regulate B Lymphocyte Signal Transduction Independent of Complement Activation J. Immunol., September 15, 2001; 167(6): 3190 - 3200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Kingsbury, L. A. Feeney, Y. Nong, S. A Calandra, C. J. Murphy, J. M. Corcoran, Y. Wang, M. R. Prabhu Das, S. J. Busfield, C. C. Fraser, et al. Cloning, Expression, and Function of BLAME, a Novel Member of the CD2 Family J. Immunol., May 1, 2001; 166(9): 5675 - 5680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sato, M. Hasegawa, M. Fujimoto, T. F. Tedder, and K. Takehara Quantitative Genetic Variation in CD19 Expression Correlates with Autoimmunity J. Immunol., December 1, 2000; 165(11): 6635 - 6643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Meola, A. Sbardellati, B. Bruni ercole, M. Cerretani, M. Pezzanera, A. Ceccacci, A. Vitelli, S. Levy, A. Nicosia, C. Traboni, et al. Binding of Hepatitis C Virus E2 Glycoprotein to CD81 Does Not Correlate with Species Permissiveness to Infection J. Virol., July 1, 2000; 74(13): 5933 - 5938. [Abstract] [Full Text]
|
|
|
|
 |
|
 N. Solvason, W. W. Wu, D. Parry, D. Mahony, E. W.-F. Lam, J. Glassford, G. G. B. Klaus, P. Sicinski, R. Weinberg, Y. J. Liu, et al. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development Int. Immunol., May 1, 2000; 12(5): 631 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, J. C. Poe, P. J. Jansen, S. Sato, and T. F. Tedder CD19 Amplifies B Lymphocyte Signal Transduction by Regulating Src-Family Protein Tyrosine Kinase Activation J. Immunol., June 15, 1999; 162(12): 7088 - 7094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Buhl and J. C. Cambier Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton's Tyrosine Kinase J. Immunol., April 15, 1999; 162(8): 4438 - 4446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Boes, C. Esau, M. B. Fischer, T. Schmidt, M. Carroll, and J. Chen Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM J. Immunol., May 15, 1998; 160(10): 4776 - 4787. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Inaoki, S. Sato, B. C. Weintraub, C. C. Goodnow, and T. F. Tedder CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes J. Exp. Med., December 1, 1997; 186(11): 1923 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fujimoto, J. C. Poe, M. Hasegawa, and T. F. Tedder CD19 Amplification of B Lymphocyte Ca2+ Responses. A ROLE FOR Lyn SEQUESTRATION IN EXTINGUISHING NEGATIVE REGULATION J. Biol. Chem., November 21, 2001; 276(48): 44820 - 44827. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
