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The Journal of Immunology, Vol 159, Issue 4 1613-1618, Copyright © 1997 by American Association of Immunologists
ARTICLES |
A Ballester, R Tobena, C Lisbona, V Calvo and S Alemany
Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Facultad de Medicina Universidad Autonoma de Madrid, Spain.
tpl-2 is a rat gene that encodes a serine/threonine protein kinase that can act as a novel mitogen-activated protein (MAP) kinase kinase kinase. Tpl-2 is activated in Moloney murine leukemia virus-induced rat T lymphomas, due to a truncation in the C-terminal region of the protein. cot is a very closely related gene, if not the human homologue. The truncated form of Cot has been shown to have a higher transforming activity than the nontruncated form. In this paper we show that an increase in truncated Cot kinase expression correlates with an increase in IL-2 production in anti-CD3-treated Jurkat cells. Truncated Cot expression also cooperates with PHA or phorbol 12,13-dibutyrate (PDBu) and calcium ionophore for IL-2 production in Jurkat cells. Both the truncated and nontruncated Cot forms increased IL-2 transcription because they enhanced transcription of a reporter gene linked to the IL- 2 promoter. The expression of a dominant negative form of Cot inhibits transcription directed by the IL-2 promoter in Jurkat cells stimulated by PDBu and ionophore. These data suggest a role of Tpl-2/Cot kinase in IL-2 production during T lymphocyte activation and could also explain its role in Moloney murine leukemia virus-induced lymphomagenesis.
This article has been cited by other articles:
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  M. Caivano, C. Rodriguez, P. Cohen, and S. Alemany 15-Deoxy-{Delta}12,14-prostaglandin J2 Regulates Endogenous Cot MAPK Kinase Kinase 1 Activity Induced by Lipopolysaccharide J. Biol. Chem., December 26, 2003; 278(52): 52124 - 52130. [Abstract] [Full Text] [PDF]
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P. L. Channavajhala, L. Wu, J. W. Cuozzo, J. P. Hall, W. Liu, L.-L. Lin, and Y. Zhang Identification of a Novel Human Kinase Supporter of Ras (hKSR-2) That Functions as a Negative Regulator of Cot (Tpl2) Signaling J. Biol. Chem., November 21, 2003; 278(47): 47089 - 47097. [Abstract] [Full Text] [PDF]
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 M. L. Gandara, P. Lopez, R. Hernando, J. G. Castano, and S. Alemany The COOH-Terminal Domain of Wild-Type Cot Regulates Its Stability and Kinase Specific Activity Mol. Cell. Biol., October 15, 2003; 23(20): 7377 - 7390. [Abstract] [Full Text] [PDF]
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L. P. Kane, M. N. Mollenauer, Z. Xu, C. W. Turck, and A. Weiss Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-{kappa}B-Dependent Transcription Mol. Cell. Biol., August 15, 2002; 22(16): 5962 - 5974. [Abstract] [Full Text] [PDF]
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 A. Velasco-Sampayo and S. Alemany p27kif Protein Levels and E2F Activity Are Targets of Cot Kinase During G1 Phase Progression in T Cells J. Immunol., May 15, 2001; 166(10): 6084 - 6090. [Abstract] [Full Text] [PDF]
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M. Chiariello, M. J. Marinissen, and J. S. Gutkind Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-jun Promoter and to Cellular Transformation Mol. Cell. Biol., March 1, 2000; 20(5): 1747 - 1758. [Abstract] [Full Text]
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 G. Varga, U. Dreikhausen, M. Kracht, A. Appel, K. Resch, and M. Szamel Molecular mechanisms of T lymphocyte activation: convergence of T cell antigen receptor and IL-1 receptor-induced signaling at the level of IL-2 gene transcription Int. Immunol., November 1, 1999; 11(11): 1851 - 1862. [Abstract] [Full Text] [PDF]
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A. Ballester, A. Velasco, R. Tobena, and S. Alemany Cot Kinase Activates Tumor Necrosis Factor-alpha Gene Expression in a Cyclosporin A-resistant Manner J. Biol. Chem., June 5, 1998; 273(23): 14099 - 14106. [Abstract] [Full Text] [PDF]
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 C. Tsatsanis, C. Patriotis, S. E. Bear, and P. N. Tsichlis The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines PNAS, March 31, 1998; 95(7): 3827 - 3832. [Abstract] [Full Text] [PDF]
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E. Sanchez-Gongora, C. Lisbona, R. de Gregorio, A. Ballester, V. Calvo, L. Perez-Jurado, and S. Alemany COT Kinase Proto-oncogene Expression in T Cells. IMPLICATION OF THE JNK/SAPK SIGNAL TRANSDUCTION PATHWAY IN COT PROMOTER ACTIVATION J. Biol. Chem., September 29, 2000; 275(40): 31379 - 31386. [Abstract] [Full Text] [PDF]
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R. de Gregorio, M. A. Iniguez, M. Fresno, and S. Alemany Cot Kinase Induces Cyclooxygenase-2 Expression in T Cells through Activation of the Nuclear Factor of Activated T Cells J. Biol. Chem., July 13, 2001; 276(29): 27003 - 27009. [Abstract] [Full Text] [PDF]
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N. Coudronniere, M. Villalba, N. Englund, and A. Altman NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta PNAS, March 28, 2000; 97(7): 3394 - 3399. [Abstract] [Full Text] [PDF]
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