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The Journal of Immunology, Vol 159, Issue 4 1594-1598, Copyright © 1997 by American Association of Immunologists
CUTTING EDGE |
PA Kiener, PM Davis, BM Rankin, SJ Klebanoff, JA Ledbetter, GC Starling and WC Liles
Immunological Diseases, Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121, USA. kienerp@bms.com
Human monocytes express both Fas and Fas ligand (FasL) on the cell surface, and the interaction of these molecules induces spontaneous apoptosis. In this report we present a study of monocytic cells by FACS and confocal microscopy using anti-FasL Abs that reveals high levels of preformed FasL within the intracellular compartment. Further analysis by immunoblotting of cell cytoplasmic proteins confirmed the presence of a 37-kDa protein recognized by anti-FasL Abs. Stimulation of the monocytic cells with immune complexes, PHA, or superantigen gave rise to the rapid release of soluble FasL from within the cells. The presence of high levels of FasL within human monocytes suggests that, upon stimulation, the cells can rapidly translocate intracellular FasL to the cell surface and release it into the extracellular milieu. These findings indicate a novel mechanism for monocytes to respond rapidly to environmental changes, resulting in the release of active, soluble FasL.
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L. Rigamonti, S. Ariotti, G. Losana, R. Gradini, M. A. Russo, E. Jouanguy, J.-L. Casanova, G. Forni, and F. Novelli Surface Expression of the IFN-{gamma}R2 Chain Is Regulated by Intracellular Trafficking in Human T Lymphocytes J. Immunol., January 1, 2000; 164(1): 201 - 207. [Abstract] [Full Text] [PDF]
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S.-i. Wakamatsu, M. Makino, C. Tei, and M. Baba Monocyte-Driven Activation-Induced Apoptotic Cell Death of Human T-Lymphotropic Virus Type I-Infected T Cells J. Immunol., October 1, 1999; 163(7): 3914 - 3919. [Abstract] [Full Text] [PDF]
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G. Matute-Bello, W. C. Liles, K. P. Steinberg, P. A. Kiener, S. Mongovin, E. Y. Chi, M. Jonas, and T. R. Martin Soluble Fas Ligand Induces Epithelial Cell Apoptosis in Humans with Acute Lung Injury (ARDS) J. Immunol., August 15, 1999; 163(4): 2217 - 2225. [Abstract] [Full Text] [PDF]
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R. K. Singh, M. L. Varney, S. Buyukberber, K. Ino, A. G. Ageitos, E. Reed, S. Tarantolo, and J. E. Talmadge Fas-FasL-mediated CD4+ T-Cell Apoptosis following Stem Cell Transplantation Cancer Res., July 1, 1999; 59(13): 3107 - 3111. [Abstract] [Full Text] [PDF]
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T. S. Griffith, S. R. Wiley, M. Z. Kubin, L. M. Sedger, C. R. Maliszewski, and N. A. Fanger Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor-related Cytokine, TRAIL J. Exp. Med., April 19, 1999; 189(8): 1343 - 1354. [Abstract] [Full Text] [PDF]
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E. Chklovskaia, W. Jansen, C. Nissen, S. D. Lyman, C. Rahner, L. Landmann, and A. Wodnar-Filipowicz Mechanism of flt3 Ligand Expression in Bone Marrow Failure: Translocation From Intracellular Stores to the Surface of T Lymphocytes After Chemotherapy-Induced Suppression of Hematopoiesis Blood, April 15, 1999; 93(8): 2595 - 2604. [Abstract] [Full Text] [PDF]
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R. De Maria, U. Testa, L. Luchetti, A. Zeuner, G. Stassi, E. Pelosi, R. Riccioni, N. Felli, P. Samoggia, and C. Peschle Apoptotic Role of Fas/Fas Ligand System in the Regulation of Erythropoiesis Blood, February 1, 1999; 93(3): 796 - 803. [Abstract] [Full Text] [PDF]
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C. R. Casella, E. L. Rapaport, and T. H. Finkel Vpu Increases Susceptibility of Human Immunodeficiency Virus Type 1-Infected Cells to Fas Killing J. Virol., January 1, 1999; 73(1): 92 - 100. [Abstract] [Full Text] [PDF]
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S. B. Brown and J. Savill Phagocytosis Triggers Macrophage Release of Fas Ligand and Induces Apoptosis of Bystander Leukocytes J. Immunol., January 1, 1999; 162(1): 480 - 485. [Abstract] [Full Text] [PDF]
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B. Kessler, D. Hudrisier, M. Schroeter, J. Tschopp, J.-C. Cerottini, and I. F. Luescher Peptide Modification or Blocking of CD8, Resulting in Weak TCR Signaling, Can Activate CTL for Fas- But Not Perforin-Dependent Cytotoxicity or Cytokine Production J. Immunol., December 15, 1998; 161(12): 6939 - 6946. [Abstract] [Full Text] [PDF]
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 N. Mitsiades, V. Poulaki, V. Kotoula, A. Leone, and M. Tsokos Fas Ligand Is Present in Tumors of the Ewing's Sarcoma Family and Is Cleaved into a Soluble Form by a Metalloproteinase Am. J. Pathol., December 1, 1998; 153(6): 1947 - 1956. [Abstract] [Full Text] [PDF]
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D. Wesch, S. Marx, and D. Kabelitz Monocyte-Dependent Death of Freshly Isolated T Lymphocytes: Induction by Phorbolester and Mitogens and Differential Effects of Catalase J. Immunol., August 1, 1998; 161(3): 1248 - 1256. [Abstract] [Full Text] [PDF]
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W. Stohl, J. E. Elliott, D. H. Lynch, and P. A. Kiener CD95 (Fas)-Based, Superantigen-Dependent, CD4+ T Cell-Mediated Down-Regulation of Human In Vitro Immunoglobulin Responses J. Immunol., June 1, 1998; 160(11): 5231 - 5238. [Abstract] [Full Text] [PDF]
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C. Smyth, G. Logan, R. P. Weinberger, P. B. Rowe, I. E. Alexander, and J. A. Smythe Identification of a Dynamic Intracellular Reservoir of CD86 Protein in Peripheral Blood Monocytes That Is Not Associated with the Golgi Complex J. Immunol., June 1, 1998; 160(11): 5390 - 5396. [Abstract] [Full Text] [PDF]
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D. Smith, S. Sieg, and D. Kaplan Technical Note: Aberrant Detection of Cell Surface Fas Ligand with Anti-Peptide Antibodies J. Immunol., May 1, 1998; 160(9): 4159 - 4160. [Abstract] [Full Text] [PDF]
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L. Genestier, S. Fournel, M. Flacher, O. Assossou, J.-P. Revillard, and N. Bonnefoy-Berard Induction of Fas (Apo-1, CD95)-Mediated Apoptosis of Activated Lymphocytes by Polyclonal Antithymocyte Globulins Blood, April 1, 1998; 91(7): 2360 - 2368. [Abstract] [Full Text] [PDF]
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 T. A. Stokes, M. Rymaszewski, P. L. Arscott, S. H. Wang, J. D. Bretz, J. Bartron, J. R. Baker Jr.;, P. Fiedler, C. E. Schaetzlein, H. Eibel;, et al. Constitutive Expression of FasL in Thyrocytes Science, March 27, 1998; 279(5359): 2015 - 2015. [Full Text]
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 P. M. Yao and I. Tabas Free Cholesterol Loading of Macrophages Induces Apoptosis Involving the Fas Pathway J. Biol. Chem., July 28, 2000; 275(31): 23807 - 23813. [Abstract] [Full Text] [PDF]
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M. Hernandez, L. Fuentes, F. J. Fernandez Aviles, M. S. Crespo, and M. L. Nieto Secretory Phospholipase A2 Elicits Proinflammatory Changes and Upregulates the Surface Expression of Fas Ligand in Monocytic Cells: Potential Relevance for Atherogenesis Circ. Res., January 11, 2002; 90(1): 38 - 45. [Abstract] [Full Text] [PDF]
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