The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takahashi, K.
Right arrow Articles by Holers, V. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takahashi, K.
Right arrow Articles by Holers, V. M.

The Journal of Immunology, Vol 159, Issue 3 1557-1569, Copyright © 1997 by American Association of Immunologists

ARTICLES

Mouse complement receptors type 1 (CR1;CD35) and type 2 (CR2;CD21): expression on normal B cell subpopulations and decreased levels during the development of autoimmunity in MRL/lpr mice

K Takahashi, Y Kozono, TJ Waldschmidt, D Berthiaume, RJ Quigg, A Baron and VM Holers
Department of Pathology, University of Iowa School of Medicine, Iowa City 52242, USA.

Human complement receptors type 1 (hCR1;CD35) and type 2 (hCR2;CD21) are expressed on B lymphocytes at specific stages during differentiation and activation. These receptors play critical roles in the immune response to T-dependent Ags in addition to germinal center formation. Expression of both hCR2 and hCR1 is decreased on B lymphocytes of patients with systemic lupus erythematosus (SLE). We have studied the expression of mouse CR2 and CR1 on normal populations of mouse B lymphocytes in BALB/c mice. Our results demonstrate that expression of these receptors in the normal state closely parallels that of hCR2. During bone marrow development, expression is first detected on low B220/high IgM cells, demonstrating that complement receptors appear after central tolerance mechanisms are completed. In the splenic microenvironment the highest levels of receptor expression are found on marginal zone B lymphocytes. Mouse CR2 and CR1 are also found on peritoneal B1a and B1b cells in addition to IgA+ Peyer's patch B cells. Activation of splenic B cells under Th2 conditions results in a marked decrease in receptor expression. To determine whether the patterns of receptor expression also parallel those found in human disease, we studied the MRL lpr/lpr (MRL/lpr) model of SLE. Interestingly, we found an early decrease in complement receptor expression that is progressive and first detectable before major clinical manifestations of nephritis. We hypothesize that the early decrease in complement receptor expression such as that demonstrated by MRL/lpr mice plays an important role in the pathogenesis of murine and perhaps human SLE.


This article has been cited by other articles:


Home page
 JEMHome page
J. H. Wang, F. W. Alt, M. Gostissa, A. Datta, M. Murphy, M. B. Alimzhanov, K. M. Coakley, K. Rajewsky, J. P. Manis, and C. T. Yan
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
J. Exp. Med., December 22, 2008; 205(13): 3079 - 3090.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
D. Liu, J.-Y. Zhu, and Z.-X. Niu
Molecular Structure and Expression of Anthropic, Ovine, and Murine Forms of Complement Receptor Type 2
Clin. Vaccine Immunol., June 1, 2008; 15(6): 901 - 910.
[Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Isaak, P. Gergely Jr, Z. Szekeres, J. Prechl, G. Poor, A. Erdei, and J. Gergely
Physiological up-regulation of inhibitory receptors Fc{gamma}RII and CR1 on memory B cells is lacking in SLE patients
Int. Immunol., February 1, 2008; 20(2): 185 - 192.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Choudhury, P. L. Cohen, and R. A. Eisenberg
Mature B Cells Preferentially Lose Tolerance in the Chronic Graft-versus-Host Disease Model of Systemic Lupus Erythematosus
J. Immunol., October 15, 2007; 179(8): 5564 - 5570.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. A. Kaminski and J. Stavnezer
Antibody class switching differs among SJL, C57BL/6 and 129 mice
Int. Immunol., April 1, 2007; 19(4): 545 - 556.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Hassler, C. Ramsey, M. C. Karlsson, D. Larsson, B. Herrmann, B. Rozell, M. Backheden, L. Peltonen, O. Kampe, and O. Winqvist
Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma
Blood, September 15, 2006; 108(6): 1941 - 1948.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Asokan, J. Hua, K. A. Young, H. J. Gould, J. P. Hannan, D. M. Kraus, G. Szakonyi, G. J. Grundy, X. S. Chen, M. K. Crow, et al.
Characterization of Human Complement Receptor Type 2 (CR2/CD21) as a Receptor for IFN-{alpha}: A Potential Role in Systemic Lupus Erythematosus
J. Immunol., July 1, 2006; 177(1): 383 - 394.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Fairweather, S. Frisancho-Kiss, D. B. Njoku, J. F. Nyland, Z. Kaya, S. A. Yusung, S. E. Davis, J. A. Frisancho, M. A. Barrett, and N. R. Rose
Complement Receptor 1 and 2 Deficiency Increases Coxsackievirus B3-Induced Myocarditis, Dilated Cardiomyopathy, and Heart Failure by Increasing Macrophages, IL-1beta, and Immune Complex Deposition in the Heart
J. Immunol., March 15, 2006; 176(6): 3516 - 3524.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Lee, K. M. Haas, D. O. Gor, X. Ding, D. R. Karp, N. S. Greenspan, J. C. Poe, and T. F. Tedder
Complement Component C3d-Antigen Complexes Can Either Augment or Inhibit B Lymphocyte Activation and Humoral Immunity in Mice Depending on the Degree of CD21/CD19 Complex Engagement
J. Immunol., December 15, 2005; 175(12): 8011 - 8023.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Chen, D. Perry, S. A. Boackle, E. S. Sobel, H. Molina, B. P. Croker, and L. Morel
Several Genes Contribute to the Production of Autoreactive B and T Cells in the Murine Lupus Susceptibility Locus Sle1c
J. Immunol., July 15, 2005; 175(2): 1080 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Birrell, L. Kulik, B. P. Morgan, V. M. Holers, and K. J. Marchbank
B Cells from Mice Prematurely Expressing Human Complement Receptor Type 2 Are Unresponsive to T-Dependent Antigens
J. Immunol., June 1, 2005; 174(11): 6974 - 6982.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Lyubchenko, J. Dal Porto, J. C. Cambier, and V. M. Holers
Coligation of the B Cell Receptor with Complement Receptor Type 2 (CR2/CD21) Using Its Natural Ligand C3dg: Activation without Engagement of an Inhibitory Signaling Pathway
J. Immunol., March 15, 2005; 174(6): 3264 - 3272.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. R. Ferguson, M. E. Youd, and R. B. Corley
Marginal zone B cells transport and deposit IgM-containing immune complexes onto follicular dendritic cells
Int. Immunol., October 1, 2004; 16(10): 1411 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. Hase, Y. Kanno, M. Kojima, K. Hasegawa, D. Sakurai, H. Kojima, N. Tsuchiya, K. Tokunaga, N. Masawa, M. Azuma, et al.
BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex
Blood, March 15, 2004; 103(6): 2257 - 2265.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kretschmer, A. Jungebloud, J. Stopkowicz, T. Kleinke, R. Hoffmann, and S. Weiss
The Selection of Marginal Zone B Cells Differs from That of B-1a Cells
J. Immunol., December 15, 2003; 171(12): 6495 - 6501.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
T. G. Phan, M. Amesbury, S. Gardam, J. Crosbie, J. Hasbold, P. D. Hodgkin, A. Basten, and R. Brink
B Cell Receptor-independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells
J. Exp. Med., April 7, 2003; 197(7): 845 - 860.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Lindorfer, H. B. Jinivizian, P. L. Foley, A. D. Kennedy, M. D. Solga, and R. P. Taylor
B Cell Complement Receptor 2 Transfer Reaction
J. Immunol., April 1, 2003; 170(7): 3671 - 3678.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Amano, E. Amano, T. Moll, D. Marinkovic, N. Ibnou-Zekri, E. Martinez-Soria, I. Semac, T. Wirth, L. Nitschke, and S. Izui
The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells
J. Immunol., March 1, 2003; 170(5): 2293 - 2301.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Y. Li, H. Li, D. Ni, and M. Weigert
Anti-DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern
J. Exp. Med., December 16, 2002; 196(12): 1543 - 1552.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Tolnay, L. A. Vereshchagina, and G. C. Tsokos
NF-{kappa}B Regulates the Expression of the Human Complement Receptor 2 Gene
J. Immunol., December 1, 2002; 169(11): 6236 - 6243.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. J. Marchbank, L. Kulik, M. G. Gipson, B. P. Morgan, and V. M. Holers
Expression of Human Complement Receptor Type 2 (CD21) in Mice During Early B Cell Development Results in a Reduction in Mature B Cells and Hypogammaglobulinemia
J. Immunol., October 1, 2002; 169(7): 3526 - 3535.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. D. Fleming, T. Shea-Donohue, J. M. Guthridge, L. Kulik, T. J. Waldschmidt, M. G. Gipson, G. C. Tsokos, and V. M. Holers
Mice Deficient in Complement Receptors 1 and 2 Lack a Tissue Injury-Inducing Subset of the Natural Antibody Repertoire
J. Immunol., August 15, 2002; 169(4): 2126 - 2133.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Wu, N. Jiang, C. Deppong, J. Singh, G. Dolecki, D. Mao, L. Morel, and H. D. Molina
A Role for the Cr2 Gene in Modifying Autoantibody Production in Systemic Lupus Erythematosus
J. Immunol., August 1, 2002; 169(3): 1587 - 1592.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Ulgiati, C. Pham, and V. M. Holers
Functional Analysis of the Human Complement Receptor 2 (CR2/CD21) Promoter: Characterization of Basal Transcriptional Mechanisms
J. Immunol., June 15, 2002; 168(12): 6279 - 6285.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Itoh, M. Itoh, K. Nishida, S. Yamasaki, Y. Yoshida, M. Narimatsu, S. J. Park, M. Hibi, K. Ishihara, and T. Hirano
Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses
J. Immunol., May 15, 2002; 168(10): 5110 - 5116.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. R. Sekiguchi, S. M. Jainandunsing, M. L. Fields, M. A. Maldonado, M. P. Madaio, J. Erikson, M. Weigert, and R. A. Eisenberg
Chronic Graft-Versus-Host in Ig Knockin Transgenic Mice Abrogates B Cell Tolerance in Anti-Double-Stranded DNA B Cells
J. Immunol., April 15, 2002; 168(8): 4142 - 4153.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. SM. Rahman, S.-K. Tin, P.-N. L. Buenaventura, C.-H. Ho, E. P. H. Yap, R. Y. Y. Yong, and D.-R. Koh
A Novel Susceptibility Locus On Chromosome 2 in the (New Zealand Black x New Zealand White)F1 Hybrid Mouse Model of Systemic Lupus Erythematosus
J. Immunol., March 15, 2002; 168(6): 3042 - 3049.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. Chakravarty, M. D. Zabel, J. J. Weis, and J. H. Weis
Depletion of Lyn kinase from the BCR complex and inhibition of B cell activation by excess CD21 ligation
Int. Immunol., February 1, 2002; 14(2): 139 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Ulgiati and V. M. Holers
CR2/CD21 Proximal Promoter Activity Is Critically Dependent on a Cell Type-Specific Repressor
J. Immunol., December 15, 2001; 167(12): 6912 - 6919.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. M. Guthridge, K. Young, M. G. Gipson, M.-R. Sarrias, G. Szakonyi, X. S. Chen, A. Malaspina, E. Donoghue, J. A. James, J. D. Lambris, et al.
Epitope Mapping Using the X-Ray Crystallographic Structure of Complement Receptor Type 2 (CR2)/CD21: Identification of a Highly Inhibitory Monoclonal Antibody That Directly Recognizes the CR2-C3d Interface
J. Immunol., November 15, 2001; 167(10): 5758 - 5766.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Z. Hao and K. Rajewsky
Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow
J. Exp. Med., October 15, 2001; 194(8): 1151 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Hasegawa, M. Fujimoto, J. C. Poe, D. A. Steeber, and T. F. Tedder
CD19 Can Regulate B Lymphocyte Signal Transduction Independent of Complement Activation
J. Immunol., September 15, 2001; 167(6): 3190 - 3200.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. L. Fields, C. L. Sokol, A. Eaton-Bassiri, S.-j. Seo, M. P. Madaio, and J. Erikson
Fas/Fas Ligand Deficiency Results in Altered Localization of Anti-Double-Stranded DNA B Cells and Dendritic Cells
J. Immunol., August 15, 2001; 167(4): 2370 - 2378.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Moir, A. Malaspina, K. M. Ogwaro, E. T. Donoghue, C. W. Hallahan, L. A. Ehler, S. Liu, J. Adelsberger, R. Lapointe, P. Hwu, et al.
HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
PNAS, August 10, 2001; (2001) 181347898.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. A. Vereshchagina, M. Tolnay, and G. C. Tsokos
Multiple Transcription Factors Regulate the Inducible Expression of the Human Complement Receptor 2 Promoter
J. Immunol., May 15, 2001; 166(10): 6156 - 6163.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. W. Makar, D. Ulgiati, J. Hagman, and V. M. Holers
A site in the complement receptor 2 (CR2/CD21) silencer is necessary for lineage specific transcriptional regulation
Int. Immunol., May 1, 2001; 13(5): 657 - 664.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Morel, K. R. Blenman, B. P. Croker, and E. K. Wakeland
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
PNAS, January 23, 2001; (2001) 31336098.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
H. Ohdan, K. G. Swenson, H. S. Kruger Gray, Y.-G. Yang, Y. Xu, A. D. Thall, and M. Sykes
Mac-1-Negative B-1b Phenotype of Natural Antibody-Producing Cells, Including Those Responding to Gal{alpha}1,3Gal Epitopes in {alpha}1,3-Galactosyltransferase-Deficient Mice
J. Immunol., November 15, 2000; 165(10): 5518 - 5529.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Z. Chen, S. B. Koralov, and G. Kelsoe
Complement C4 Inhibits Systemic Autoimmunity through a Mechanism Independent of Complement Receptors CR1 and CR2
J. Exp. Med., November 6, 2000; 192(9): 1339 - 1352.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. S. Eaton-Bassiri, L. Mandik-Nayak, S.-j. Seo, M. P. Madaio, M. P. Cancro, and J. Erikson
Alterations in splenic architecture and the localization of anti-double-stranded DNA B cells in aged mice
Int. Immunol., June 1, 2000; 12(6): 915 - 926.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Feuerstein, F. Chen, M. Madaio, M. Maldonado, and R. A. Eisenberg
Induction of Autoimmunity in a Transgenic Model of B Cell Receptor Peripheral Tolerance: Changes in Coreceptors and B Cell Receptor-Induced Tyrosine-Phosphoproteins
J. Immunol., November 15, 1999; 163(10): 5287 - 5297.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
R. J. Benschop, D. Melamed, D. Nemazee, and J. C. Cambier
Distinct Signal Thresholds for the Unique Antigen Receptor–linked Gene Expression Programs in Mature and Immature B Cells
J. Exp. Med., September 20, 1999; 190(6): 749 - 756.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Mandik-Nayak, S.-j. Seo, C. Sokol, K. M. Potts, A. Bui, and J. Erikson
MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti-double-stranded DNA B Cells
J. Exp. Med., June 7, 1999; 189(11): 1799 - 1814.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
H. Noorchashm, A. Bui, H.-L. Li, A. Eaton, L. Mandik-Nayak, C. Sokol, K. M. Potts, E. Pure, and J. Erikson
Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process
Int. Immunol., May 1, 1999; 11(5): 765 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Boackle, M. A. Morris, V. M. Holers, and D. R. Karp
Complement Opsonization Is Required for Presentation of Immune Complexes by Resting Peripheral Blood B Cells
J. Immunol., December 15, 1998; 161(12): 6537 - 6543.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Amano, N. Baumgarth, M. D. Dick, L. Brossay, M. Kronenberg, L. A. Herzenberg, and S. Strober
CD1 Expression Defines Subsets of Follicular and Marginal Zone B Cells in the Spleen: {beta}2-Microglobulin-Dependent and Independent Forms
J. Immunol., August 15, 1998; 161(4): 1710 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. H. Roark, S.-H. Park, J. Jayawardena, U. Kavita, M. Shannon, and A. Bendelac
CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells
J. Immunol., April 1, 1998; 160(7): 3121 - 3127.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. W. Makar, C. T. N. Pham, M. H. Dehoff, S. M. O'Connor, S. M. Jacobi, and V. M. Holers
An Intronic Silencer Regulates B Lymphocyte Cell- and Stage-Specific Expression of the Human Complement Receptor Type 2 (CR2, CD21) Gene
J. Immunol., February 1, 1998; 160(3): 1268 - 1278.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Morel, K. R. Blenman, B. P. Croker, and E. K. Wakeland
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
PNAS, February 13, 2001; 98(4): 1787 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Moir, A. Malaspina, K. M. Ogwaro, E. T. Donoghue, C. W. Hallahan, L. A. Ehler, S. Liu, J. Adelsberger, R. Lapointe, P. Hwu, et al.
HIV-1 induces phenotypic and functional perturbations of B cells in chronically infected individuals
PNAS, August 28, 2001; 98(18): 10362 - 10367.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.