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The Journal of Immunology, Vol 159, Issue 3 1328-1335, Copyright © 1997 by American Association of Immunologists
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VE Garcia, PA Sieling, J Gong, PF Barnes, K Uyemura, Y Tanaka, BR Bloom, CT Morita and RL Modlin
Division of Dermatology, University of California Los Angeles School of Medicine, 90095, USA.
TCR gamma delta T cells are considered important in the rapid immune response to intracellular infection. We investigated the early response of peripheral blood gamma delta T cells to the nonpeptide Ag isopentenyl pyrophosphate and to its synthetic analogue ethyl pyrophosphate. In healthy donors, an increase in the number of gamma delta T cells was detected as soon as 4 days after stimulation with the nonpeptide Ags. Single-cell analysis of cytokine production was performed by intracellular staining of IFN-gamma and IL-4. gamma delta T cells were found to rapidly expand and produce IFN-gamma in response to nonpeptide Ags. Furthermore, IL-12 augmented the IFN-gamma response. In contrast, gamma delta T cells from the majority of HIV+ donors did not expand or express IFN-gamma in response to nonpeptide Ags, even in the presence of IL-12. These findings indicate a role for nonpeptide- reactive gamma delta T cells in effective cell-mediated immunity for intracellular pathogens.
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