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The Journal of Immunology, Vol 159, Issue 2 777-785, Copyright © 1997 by American Association of Immunologists

ARTICLES

IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis

LR Brunet, FD Finkelman, AW Cheever, MA Kopf and EJ Pearce
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

To examine the role of the Th2-type response during schistosomiasis mansoni we compared disease progression in wild type (wt), and Th2- response deficient IL-4(-/-) mice. Whereas wt C57BL/6 mice tolerate infection and develop chronic disease, IL-4(-/-) C57BL/6 animals are highly susceptible, exhibiting severe acute cachexia followed by death. Data point toward morbidity in the IL-4(-/-) C57BL/6 mice being mediated by TNF-alpha, possibly through the uncontrolled production of nitric oxide in target organs such as the ileum. We propose that IL-4 prevents severe disease during schistosomiasis by regulating macrophage activation.


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