The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cascalho, M.
Right arrow Articles by Wabl, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cascalho, M.
Right arrow Articles by Wabl, M.

The Journal of Immunology, Vol 159, Issue 12 5795-5801, Copyright © 1997 by American Association of Immunologists

ARTICLES

VH gene replacement in hyperselected B cells of the quasimonoclonal mouse

M Cascalho, J Wong and M Wabl
Department of Microbiology and Immunology, University of California, San Francisco 94143-0670, USA.

The primary repertoire of the quasimonoclonal mouse is monospecific. However, among peripheral B cells, there is a high frequency of variant cells with V(H) replacements, which are also hypermutated. We show in this work that these hyperselected cells expand in numbers as the animals increase in age, switch their isotypes, and with increasing age become the almost exclusive contributors to the pool of serum Ig. The fraction of such cells is higher in the peritoneum than in peripheral blood, supporting the view that the peritoneum is a site of production of nonspecific serum Ig. We have also isolated and partially sequenced the replacing V(H) gene segments from B220-positive, Id-negative cells, and mu-negative, lambda-positive (i.e., switched) cells, and matched them with their germline counterparts. V(H) families are represented proportional to the number of members in the germline, a finding that is consistent with the idea that environmental Ag pressure maintains the germline repertoire of V gene segment.


This article has been cited by other articles:


Home page
 JEMHome page
M. Davila, F. Liu, L. G. Cowell, A. E. Lieberman, E. Heikamp, A. Patel, and G. Kelsoe
Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro B cells
J. Exp. Med., December 24, 2007; 204(13): 3195 - 3208.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. T. Mantchev, C. S. Cortesao, M. Rebrovich, M. Cascalho, and R. J. Bram
TACI Is Required for Efficient Plasma Cell Differentiation in Response to T-Independent Type 2 Antigens
J. Immunol., August 15, 2007; 179(4): 2282 - 2288.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Lutz, W. Muller, and H.-M. Jack
VH Replacement Rescues Progenitor B Cells with Two Nonproductive VDJ Alleles
J. Immunol., November 15, 2006; 177(10): 7007 - 7014.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. L. Harris, I. Spoerri, J. F. Schopfer, C. Nembrini, P. Merky, J. Massacand, J. F. Urban Jr., A. Lamarre, K. Burki, B. Odermatt, et al.
Mechanisms of Neonatal Mucosal Antibody Protection
J. Immunol., November 1, 2006; 177(9): 6256 - 6262.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. C. Watson, C. S. Moffatt-Blue, R. Z. McDonald, E. Kompfner, D. Ait-Azzouzene, D. Nemazee, A. N. Theofilopoulos, D. H. Kono, and A. J. Feeney
Paucity of V-D-D-J Rearrangements and VH Replacement Events in Lupus Prone and Nonautoimmune TdT-/- and TdT+/+ Mice
J. Immunol., July 15, 2006; 177(2): 1120 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. Heltemes-Harris, X. Liu, and T. Manser
An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion
Int. Immunol., November 1, 2005; 17(11): 1447 - 1461.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Kanayama, M. Cascalho, and H. Ohmori
Analysis of Marginal Zone B Cell Development in the Mouse with Limited B Cell Diversity: Role of the Antigen Receptor Signals in the Recruitment of B Cells to the Marginal Zone
J. Immunol., February 1, 2005; 174(3): 1438 - 1445.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. C. Whitmore, H. R. Neely, R. Diz, and P. M. Flood
Rapid Induction of Splenic and Peritoneal B-1a Cells in Adult Mice by Thymus-Independent Type-2 Antigen
J. Immunol., November 1, 2004; 173(9): 5406 - 5414.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Joao, B. M. Ogle, C. Gay-Rabinstein, J. L. Platt, and M. Cascalho
B Cell-Dependent TCR Diversification
J. Immunol., April 15, 2004; 172(8): 4709 - 4716.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Heltemes-Harris, X. Liu, and T. Manser
Progressive Surface B Cell Antigen Receptor Down-Regulation Accompanies Efficient Development of Antinuclear Antigen B Cells to Mature, Follicular Phenotype
J. Immunol., January 15, 2004; 172(2): 823 - 833.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
B. M. Ogle, M. Cascalho, C. Joao, W. Taylor, L. J. West, and J. L. Platt
Direct measurement of lymphocyte receptor diversity
Nucleic Acids Res., November 15, 2003; 31(22): e139 - e139.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Hangartner, B. M. Senn, B. Ledermann, U. Kalinke, P. Seiler, E. Bucher, R. M. Zellweger, K. Fink, B. Odermatt, K. Burki, et al.
Antiviral immune responses in gene-targeted mice expressing the immunoglobulin heavy chain of virus-neutralizing antibodies
PNAS, October 28, 2003; 100(22): 12883 - 12888.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Kanayama, T. Kimoto, K. Todo, Y. Nishikawa, M. Hikida, M. Magari, M. Cascalho, and H. Ohmori
B Cell Selection and Affinity Maturation During an Antibody Response in the Mouse with Limited B Cell Diversity
J. Immunol., December 15, 2002; 169(12): 6865 - 6874.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. J. Driver, L. J. McHeyzer-Williams, M. Cool, D. B. Stetson, and M. G. McHeyzer-Williams
Development and Maintenance of a B220- Memory B Cell Compartment
J. Immunol., August 1, 2001; 167(3): 1393 - 1405.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Golub, D. Martin, F. E. Bertrand, M. Cascalho, M. Wabl, and G. E. Wu
VH Gene Replacement in Thymocytes
J. Immunol., January 15, 2001; 166(2): 855 - 860.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
K. Itoh, E. Meffre, E. Albesiano, A. Farber, D. Dines, P. Stein, S. E. Asnis, R. A. Furie, R. I. Jain, and N. Chiorazzi
Immunoglobulin Heavy Chain Variable Region Gene Replacement As a Mechanism for Receptor Revision in Rheumatoid Arthritis Synovial Tissue B Lymphocytes
J. Exp. Med., October 16, 2000; 192(8): 1151 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. D. Klonowski and M. Monestier
Heavy Chain Revision in MRL Mice: A Potential Mechanism for the Development of Autoreactive B Cell Precursors
J. Immunol., October 15, 2000; 165(8): 4487 - 4493.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
P. C. Wilson, K. Wilson, Y.-J. Liu, J. Banchereau, V. Pascual, and J. D. Capra
Receptor Revision of Immunoglobulin Heavy Chain Variable Region Genes in Normal Human B Lymphocytes
J. Exp. Med., May 30, 2000; 191(11): 1881 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. J. McHeyzer-Williams, M. Cool, and M. G. McHeyzer-Williams
Antigen-specific B Cell Memory: Expression and Replenishment of a Novel B220- Memory B Cell Compartment
J. Exp. Med., April 3, 2000; 191(7): 1149 - 1166.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. G. de Vinuesa, M. C. Cook, J. Ball, M. Drew, Y. Sunners, M. Cascalho, M. Wabl, G. G.B. Klaus, and I. C.M. MacLennan
Germinal Centers without T Cells
J. Exp. Med., February 7, 2000; 191(3): 485 - 494.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Cascalho, J. Wong, J. Brown, H.-M. Jack, C. Steinberg, and M. Wabl
A B220-, CD19- population of B cells in the peripheral blood of quasimonoclonal mice
Int. Immunol., January 1, 2000; 12(1): 29 - 35.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C. Lopez-Macias, U. Kalinke, M. Cascalho, M. Wabl, H. Hengartner, R. M. Zinkernagel, and A. Lamarre
Secondary Rearrangements and Hypermutation Generate Sufficient B Cell Diversity to Mount Protective Antiviral Immunoglobulin Responses
J. Exp. Med., June 7, 1999; 189(11): 1791 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Cascalho, J. Wong, C. Steinberg, and M. Wabl
Mismatch Repair Co-opted by Hypermutation
Science, February 20, 1998; 279(5354): 1207 - 1210.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.