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The Journal of Immunology, Vol 159, Issue 12 5777-5781, Copyright © 1997 by American Association of Immunologists

CUTTING EDGE

Cutting Edge: Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization

RB Mendoza, MJ Cantwell and TJ Kipps
Human Gene Therapy Program, University of California-San Diego, La Jolla 92093-0663, USA.

Interaction of CD40 with its ligand (CD154) can induce CD40-bearing APCs to express immune stimulatory accessory molecules that facilitate immune recognition. We evaluated whether a plasmid vector encoding CD154 (pCD40L) could influence the immune response to a transgene protein encoded by coinjected plasmid DNA. We found that coinjection of pCD40L in BALB/c mice enhanced the Ab response to beta-galactosidase induced by i.m. or intradermal injection of placZ, a plasmid DNA vector encoding beta-galactosidase. Furthermore, i.m. or intradermal coinjection of pCD40L with placZ enhanced the generation of CTL specific for P815 cells transfected with placZ. This study indicates that pCD40L can serve as a genetic adjuvant capable of augmenting humoral and cellular immune responses to Ags encoded by plasmid DNA expression vectors.


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