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The Journal of Immunology, Vol 159, Issue 11 5264-5272, Copyright © 1997 by American Association of Immunologists
ARTICLES |
G Bonizzi, J Piette, MP Merville and V Bours
Laboratory of Medical Chemistry/Medical Oncology, University of Liege, Belgium.
We previously demonstrated that IL-1beta-mediated induction of the nuclear factor-kappaB (NF-kappaB) transcription factor proceeds through the production of reactive oxygen intermediates in lymphoid cells, while it occurs independently of any oxidative stress in epithelial transformed cells. Indeed, inhibition of receptor internalization as well as NH4Cl and chloroquine blocked IL-1beta-mediated induction of NF- kappaB in OVCAR-3 and in other epithelial cell lines but not in lymphoid cells, indicating that distinct pathways are involved. Conversely, while we observed phospholipase A2 activity in both cell types following IL-1beta stimulation, specific inhibitors of this enzyme inhibited NF-kappaB induction only in lymphoid cells. Moreover, expression of the 5-lipoxygenase (5-LOX) enzyme was not detected in epithelial cells, and inhibition of this enzyme blocked NF-kappaB induction by IL-1beta only in lymphoid cells. This study thus indicates that the activation of NF-kappaB following IL-1beta treatment involves the activation of phospholipase A2 and 5-LOX and the production of reactive oxygen intermediates (ROIs) in lymphoid cells, while in epithelial cells, another pathway predominates and could involve the acid sphingomyelinase. Moreover, arachidonic acid could induce NF- kappaB in epithelial and lymphoid cells, but this activation involved the 5-LOX enzyme and the production of ROIs only in lymphoid cells. The inefficiency of the ROI pathway in epithelial cells is probably the consequence of both low ROI production due to undetectable expression of 5-LOX and rapid degradation of hydrogen peroxide due to high catalase activity.
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S. Shishodia and B. B. Aggarwal Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Activation of Cigarette Smoke-Induced Nuclear Factor (NF)-{kappa}B by Suppressing Activation of I-{kappa}B {alpha} Kinase in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of Cyclin D1, COX-2, and Matrix Metalloproteinase-9 Cancer Res., July 15, 2004; 64(14): 5004 - 5012. [Abstract] [Full Text] [PDF]
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S. Shishodia, S. Majumdar, S. Banerjee, and B. B. Aggarwal Ursolic Acid Inhibits Nuclear Factor-{kappa}B Activation Induced by Carcinogenic Agents through Suppression of I{kappa}B{alpha} Kinase and p65 Phosphorylation: Correlation with Down-Regulation of Cyclooxygenase 2, Matrix Metalloproteinase 9, and Cyclin D1 Cancer Res., August 1, 2003; 63(15): 4375 - 4383. [Abstract] [Full Text] [PDF]
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S. Xiong, H. She, H. Takeuchi, B. Han, J. F. Engelhardt, C. H. Barton, E. Zandi, C. Giulivi, and H. Tsukamoto Signaling Role of Intracellular Iron in NF-kappa B Activation J. Biol. Chem., May 9, 2003; 278(20): 17646 - 17654. [Abstract] [Full Text] [PDF]
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K. Ashikawa, S. Majumdar, S. Banerjee, A. C. Bharti, S. Shishodia, and B. B. Aggarwal Piceatannol Inhibits TNF-Induced NF-{kappa}B Activation and NF-{kappa}B-Mediated Gene Expression Through Suppression of I{kappa}B{alpha} Kinase and p65 Phosphorylation J. Immunol., December 1, 2002; 169(11): 6490 - 6497. [Abstract] [Full Text] [PDF]
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R. J. Anto, A. Mukhopadhyay, S. Shishodia, C. G. Gairola, and B. B. Aggarwal Cigarette smoke condensate activates nuclear transcription factor-{kappa}B through phosphorylation and degradation of I{kappa}B{alpha}: correlation with induction of cyclooxygenase-2 Carcinogenesis, September 1, 2002; 23(9): 1511 - 1518. [Abstract] [Full Text] [PDF]
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S. Majumdar, B. Lamothe, and B. B. Aggarwal Thalidomide Suppresses NF-{kappa}B Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester J. Immunol., March 15, 2002; 168(6): 2644 - 2651. [Abstract] [Full Text] [PDF]
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S. Majumdar and B. B. Aggarwal Methotrexate Suppresses NF-{kappa}B Activation Through Inhibition of I{kappa}B{alpha} Phosphorylation and Degradation J. Immunol., September 1, 2001; 167(5): 2911 - 2920. [Abstract] [Full Text] [PDF]
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S. K. Manna, N. K. Sah, R. A. Newman, A. Cisneros, and B. B. Aggarwal Oleandrin Suppresses Activation of Nuclear Transcription Factor-{{kappa}}B, Activator Protein-1, and c-Jun NH2-Terminal Kinase Cancer Res., July 1, 2000; 60(14): 3838 - 3847. [Abstract] [Full Text]
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S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-{kappa}B, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation J. Immunol., June 15, 2000; 164(12): 6509 - 6519. [Abstract] [Full Text] [PDF]
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S. K. Manna and B. B. Aggarwal Vesnarinone Suppresses TNF-Induced Activation of NF-{kappa}B, c-Jun Kinase, and Apoptosis J. Immunol., June 1, 2000; 164(11): 5815 - 5825. [Abstract] [Full Text] [PDF]
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S. K. Manna, A. Mukhopadhyay, and B. B. Aggarwal Human Chorionic Gonadotropin Suppresses Activation of Nuclear Transcription Factor-kappa B and Activator Protein-1 Induced by Tumor Necrosis Factor J. Biol. Chem., April 28, 2000; 275(18): 13307 - 13314. [Abstract] [Full Text] [PDF]
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S. Schoonbroodt, V. Ferreira, M. Best-Belpomme, J. R. Boelaert, S. Legrand-Poels, M. Korner, and J. Piette Crucial Role of the Amino-Terminal Tyrosine Residue 42 and the Carboxyl-Terminal PEST Domain of I{kappa}B{alpha} in NF-{kappa}B Activation by an Oxidative Stress J. Immunol., April 15, 2000; 164(8): 4292 - 4300. [Abstract] [Full Text] [PDF]
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 B. Han and C. D. Logsdon CCK stimulates mob-1 expression and NF-kappa B activation via protein kinase C and intracellular Ca2+ Am J Physiol Cell Physiol, February 1, 2000; 278(2): C344 - C351. [Abstract] [Full Text] [PDF]
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 M. PETERS-GOLDEN and T. G. BROCK Intracellular Compartmentalization of Leukotriene Biosynthesis Am. J. Respir. Crit. Care Med., February 1, 2000; 161(2): S36 - 40. [Full Text] [PDF]
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M. I. Wickremasinghe, L. H. Thomas, and J. S. Friedland Pulmonary Epithelial Cells are a Source of IL-8 in the Response to Mycobacterium tuberculosis: Essential Role of IL-1 from Infected Monocytes in a NF-{kappa}B-Dependent Network J. Immunol., October 1, 1999; 163(7): 3936 - 3947. [Abstract] [Full Text] [PDF]
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D. Thaloor, K. J. Miller, J. Gephart, P. O. Mitchell, and G. K. Pavlath Systemic administration of the NF-kappa B inhibitor curcumin stimulates muscle regeneration after traumatic injury Am J Physiol Cell Physiol, August 1, 1999; 277(2): C320 - C329. [Abstract] [Full Text] [PDF]
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