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The Journal of Immunology, Vol 159, Issue 11 5187-5191, Copyright © 1997 by American Association of Immunologists
CUTTING EDGE |
MG Levisetti, PA Padrid, GL Szot, N Mittal, SM Meehan, CL Wardrip, GS Gray, DS Bruce, JR Thistlethwaite Jr and JA Bluestone
Department of Surgery, University of Chicago, IL 60637, USA.
Ag-specific T cell activation requires a CD28-mediated costimulatory interaction. This observation has suggested novel approaches to suppress donor-specific immunity, including the use of soluble CD28 antagonists, such as CTLA4Ig, which suppresses transplant rejection in small animal models. In this study, CTLA4Ig therapy was examined in a non-human primate model of allogeneic pancreatic islet transplantation. Two of five CTLA4Ig-treated monkeys showed prolonged graft survival, which correlated with donor-specific hyporesponsiveness in vitro. Humoral responses to the transplanted tissue were suppressed in all treated animals. These results suggest that CTLA4Ig is effective in suppressing both humoral and cellular immune responses in a non-human primate model of allogeneic transplantation.
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