The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salcedo, M.
Right arrow Articles by Ljunggren, H. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salcedo, M.
Right arrow Articles by Ljunggren, H. G.

The Journal of Immunology, Vol 158, Issue 7 3174-3180, Copyright © 1997 by American Association of Immunologists

ARTICLES

Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice

M Salcedo, AD Diehl, MY Olsson-Alheim, J Sundback, L Van Kaer, K Karre and HG Ljunggren
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.

MHC class I molecules in the host affect the specificity of NK cells. Previous work has suggested that this specificity is conferred by the expression of products encoded by the Ly49 gene family. This gene family encodes receptors that upon specific recognition of MHC class I ligands mediate an inhibitory signal that prevents killing by NK cells. The pattern of expression of the Ly49 MHC class I binding inhibitory receptors on NK cells is thought to be adapted to the host to ensure the generation of a self-tolerant, yet functional, NK cell repertoire. In the present study we have examined the expression of inhibitory receptors (Ly49A, Ly49C, and Ly49G2) on NK1.1+ cells from B6 (H-2b) and D8 (B6 mice transgenic for H-2Dd) mice as well as corresponding TAP1 -/- , beta2m -/-, and TAP1/beta2m -/- mutants of these mice. We demonstrate that receptor expression on NK1.1+ cells can be specifically modulated by host MHC class I molecules in at least two different ways: alteration of numbers of cells expressing a given receptor and modulation of the levels of expression of a given receptor at the cell surface. The degree of this modulation varies significantly among the various receptors studied and may depend upon the nature of their MHC class I ligands. The results are discussed in relation to the influence of MHC class I molecules on the development of an NK cell repertoire.


This article has been cited by other articles:


Home page
 BloodHome page
M. Yawata, N. Yawata, M. Draghi, F. Partheniou, A.-M. Little, and P. Parham
MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response
Blood, September 15, 2008; 112(6): 2369 - 2380.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. W. MacFarlane IV, T. Yamazaki, M. Fang, L. J. Sigal, T. Kurosaki, and K. S. Campbell
Enhanced NK-cell development and function in BCAP-deficient mice
Blood, July 1, 2008; 112(1): 131 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
Y. Hayakawa, S. V. Watt, K. Takeda, and M. J. Smyth
Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression
J. Leukoc. Biol., January 1, 2008; 83(1): 106 - 111.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
R. S. Goldszmid, A. Bafica, D. Jankovic, C. G. Feng, P. Caspar, R. Winkler-Pickett, G. Trinchieri, and A. Sher
TAP-1 indirectly regulates CD4+ T cell priming in Toxoplasma gondii infection by controlling NK cell IFN-{gamma} production
J. Exp. Med., October 29, 2007; 204(11): 2591 - 2602.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. E. McNerney, D. Guzior, and V. Kumar
2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice
Blood, August 15, 2005; 106(4): 1337 - 1340.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Taki, S. Nakajima, E. Ichikawa, T. Saito, and S. Hida
IFN Regulatory Factor-2 Deficiency Revealed a Novel Checkpoint Critical for the Generation of Peripheral NK Cells
J. Immunol., May 15, 2005; 174(10): 6005 - 6012.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Toyama-Sorimachi, Y. Omatsu, A. Onoda, Y. Tsujimura, T. Iyoda, A. Kikuchi-Maki, H. Sorimachi, T. Dohi, S. Taki, K. Inaba, et al.
Inhibitory NK Receptor Ly49Q Is Expressed on Subsets of Dendritic Cells in a Cellular Maturation- and Cytokine Stimulation-Dependent Manner
J. Immunol., April 15, 2005; 174(8): 4621 - 4629.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. Johansson, M. Johansson, E. Rosmaraki, G. Vahlne, R. Mehr, M. Salmon-Divon, F. Lemonnier, K. Karre, and P. Hoglund
Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules
J. Exp. Med., April 4, 2005; 201(7): 1145 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Y. Koh, J. R. Ortaldo, B. R. Blazar, M. Bennett, and W. J. Murphy
NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade
Blood, December 1, 2003; 102(12): 4067 - 4075.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
E. Schott, R. Bonasio, and H. L. Ploegh
Elimination In Vivo of Developing T Cells by Natural Killer Cells
J. Exp. Med., October 20, 2003; 198(8): 1213 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Belkin, M. Torkar, C. Chang, R. Barten, M. Tolaini, A. Haude, R. Allen, M. J. Wilson, D. Kioussis, and J. Trowsdale
Killer Cell Ig-Like Receptor and Leukocyte Ig-Like Receptor Transgenic Mice Exhibit Tissue- and Cell-Specific Transgene Expression
J. Immunol., September 15, 2003; 171(6): 3056 - 3063.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. G. Shilling, N. Young, L. A. Guethlein, N. W. Cheng, C. M. Gardiner, D. Tyan, and P. Parham
Genetic Control of Human NK Cell Repertoire
J. Immunol., July 1, 2002; 169(1): 239 - 247.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Van Beneden, A. De Creus, F. Stevenaert, V. Debacker, J. Plum, and G. Leclercq
Expression of Inhibitory Receptors Ly49E and CD94/NKG2 on Fetal Thymic and Adult Epidermal TCR V{gamma}3 Lymphocytes
J. Immunol., April 1, 2002; 168(7): 3295 - 3302.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. S. Miller and V. McCullar
Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2A and KIR2DL2/L3/S2
Blood, August 1, 2001; 98(3): 705 - 713.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Fahlen, U. Lendahl, and C. L. Sentman
MHC Class I-Ly49 Interactions Shape the Ly49 Repertoire on Murine NK Cells
J. Immunol., June 1, 2001; 166(11): 6585 - 6592.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
N. Matsumoto, K. Tajima, M. Mitsuki, and K. Yamamoto
H-2 allele specificity of the NK cell C-type lectin-like MHC class I receptor Ly49A visualized by soluble Ly49A tetramer
Int. Immunol., May 1, 2001; 13(5): 615 - 623.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Van Beneden, F. Stevenaert, A. De Creus, V. Debacker, J. De Boever, J. Plum, and G. Leclercq
Expression of Ly49E and CD94/NKG2 on Fetal and Adult NK Cells
J. Immunol., April 1, 2001; 166(7): 4302 - 4311.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Toyama-Sorimachi, Y. Taguchi, H. Yagita, F. Kitamura, A. Kawasaki, S. Koyasu, and H. Karasuyama
Mouse CD94 Participates in Qa-1-Mediated Self Recognition by NK Cells and Delivers Inhibitory Signals Independent of Ly-49
J. Immunol., March 15, 2001; 166(6): 3771 - 3779.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. M. Tanamachi, T. Hanke, H. Takizawa, A. M. Jamieson, and D. H. Raulet
Expression of Natural Killer Receptor Alleles at Different Ly49 Loci Occurs Independently and Is Regulated by Major Histocompatibility Complex Class I Molecules
J. Exp. Med., January 29, 2001; 193(3): 307 - 316.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. D. Peacock, M. Y. Lin, J. R. Ortaldo, and R. M. Welsh
The Virus-Specific and Allospecific Cytotoxic T-Lymphocyte Response to Lymphocytic Choriomeningitis Virus Is Modified in a Subpopulation of CD8+ T Cells Coexpressing the Inhibitory Major Histocompatibility Complex Class I Receptor Ly49G2
J. Virol., August 1, 2000; 74(15): 7032 - 7038.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
B. Lowin-Kropf, B. Kunz, F. Beermann, and W. Held
Impaired Natural Killing of MHC Class I-Deficient Targets by NK Cells Expressing a Catalytically Inactive Form of SHP-1
J. Immunol., August 1, 2000; 165(3): 1314 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
L. Fahlen, L. Oberg, T. Brannstrom, N. K. S. Khoo, U. Lendahl, and C. L. Sentman
Ly49A expression on T cells alters T cell selection
Int. Immunol., February 1, 2000; 12(2): 215 - 222.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Korten, E. Wilk, J. E. Gessner, D. Meyer, and R. E. Schmidt
Altered Donor and Recipient Ly49+ NK Cell Subsets in Allogeneic H-2d -> H-2b and H-2b -> H-2d Bone Marrow Chimeras
J. Immunol., December 1, 1999; 163(11): 5896 - 5905.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. H. Chung, J. Dorfman, D. Plaksin, K. Natarajan, I. M. Belyakov, R. Hunziker, J. A. Berzofsky, W. M. Yokoyama, M. G. Mage, and D. H. Margulies
NK and CTL Recognition of a Single Chain H-2Dd Molecule: Distinct Sites of H-2Dd Interact with NK and TCR
J. Immunol., October 1, 1999; 163(7): 3699 - 3708.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. Toomey, M. Salcedo, L. A. Cotterill, M. M. Millrain, Z. Chrzanowska-Lightowlers, J. Lawry, K. Fraser, F. Gays, J. H. Robinson, S. Shrestha, et al.
Stochastic Acquisition of Qa1 Receptors During the Development of Fetal NK Cells In Vitro Accounts in Part But Not in Whole for the Ability of These Cells to Distinguish Between Class I-Sufficient and Class I-Deficient Targets
J. Immunol., September 15, 1999; 163(6): 3176 - 3184.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Depatie, A. Chalifour, C. Pare, S.-H. Lee, S. M. Vidal, and S. Lemieux3
Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets
Int. Immunol., September 1, 1999; 11(9): 1541 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. O. Manilay, G. L. Waneck, and M. Sykes
Levels of Ly-49 Receptor Expression Are Determined by the Frequency of Interactions with MHC Ligands: Evidence Against Receptor Calibration to a ""Useful"" Level
J. Immunol., September 1, 1999; 163(5): 2628 - 2633.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. C. George, J. R. Ortaldo, S. Lemieux, V. Kumar, and M. Bennett
Tolerance and Alloreactivity of the Ly49D Subset of Murine NK Cells
J. Immunol., August 15, 1999; 163(4): 1859 - 1867.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Kubota, S. Kubota, S. Lohwasser, D. L. Mager, and F. Takei
Diversity of NK Cell Receptor Repertoire in Adult and Neonatal Mice
J. Immunol., July 1, 1999; 163(1): 212 - 216.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Y. Olsson-Alheim, J. Sundback, K. Karre, and C. L. Sentman
The MHC Class I Molecule H-2Dp Inhibits Murine NK Cells via the Inhibitory Receptor Ly49A
J. Immunol., June 15, 1999; 162(12): 7010 - 7014.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
C. S. Chang, L. Brossay, M. Kronenberg, and K. P. Kane
The Murine Nonclassical Class I Major Histocompatibility Complex-like CD1.1 Molecule Protects Target Cells from Lymphokine-activated Killer Cell Cytolysis
J. Exp. Med., February 1, 1999; 189(3): 483 - 491.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Andersson, S. Freland, M. H. Johansson, R. Wallin, J. K. Sandberg, B. J. Chambers, B. Christensson, U. Lendahl, S. Lemieux, M. Salcedo, et al.
MHC Class I Mosaic Mice Reveal Insights into Control of Ly49C Inhibitory Receptor Expression in NK Cells
J. Immunol., December 15, 1998; 161(12): 6475 - 6479.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. R. Dorfman and D. H. Raulet
Acquisition of Ly49 Receptor Expression by Developing Natural Killer Cells
J. Exp. Med., February 16, 1998; 187(4): 609 - 618.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. H. Johansson, C. Bieberich, G. Jay, K. Karre, and P. Hoglund
Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene
J. Exp. Med., August 4, 1997; 186(3): 353 - 364.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.