The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakamura, T.
Right arrow Articles by Flavell, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakamura, T.
Right arrow Articles by Flavell, R. A.
Right arrowPubmed/NCBI databases
*Substance via MeSH

The Journal of Immunology, Vol 158, Issue 6 2648-2653, Copyright © 1997 by American Association of Immunologists

ARTICLES

Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type 1 and 2 phenotype

T Nakamura, RK Lee, SY Nam, ER Podack, K Bottomly and RA Flavell
Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT 06520, USA.

It has previously been reported that Th1 CD4 T cell populations can be converted to IL-4 producers, whereas Th2 populations are refractory to IL-12-mediated IFN-gamma production. We have recently shown that CD30 is a marker for the IL-4 response and have therefore used CD30 here to study Th1 and Th2 commitment. We show that Th2 cell populations normally show a stable phenotype and fail to respond to IL-12 because of endogenous IL-4 production. IFN-gamma abrogates this antagonistic effect of IL-4 and permits the conversion of Th2 populations to IFN- gamma producers by IL-12. In the complete absence of IL-4, however, IFN- gamma is not required for this transformation, and Th1 cells generated by IL-12 become committed to the Th1 pathway and lose the ability to respond to IL-4. Thus, the balance between local IL-4 and IFN-gamma in an immune response is a key factor in determining the outcome of the CD4 effector T cell response.


This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
M. Feili-Hariri, D. H. Falkner, and P. A. Morel
Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy
J. Leukoc. Biol., September 1, 2005; 78(3): 656 - 664.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Shirota, M. Gursel, and D. M. Klinman
Suppressive Oligodeoxynucleotides Inhibit Th1 Differentiation by Blocking IFN-{gamma}- and IL-12-Mediated Signaling
J. Immunol., October 15, 2004; 173(8): 5002 - 5007.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
P. Anderson, A. Sundstedt, L. Li, E. J. O'Neill, S. Li, D. C. Wraith, and P. Wang
Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in Th1 and Th2 cells
Int. Immunol., November 1, 2003; 15(11): 1309 - 1317.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
S Futagami, T Hiratsuka, A Tatsuguchi, K Suzuki, M Kusunoki, Y Shinji, K Shinoki, T Iizumi, T Akamatsu, H Nishigaki, et al.
Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells
Gut, September 1, 2003; 52(9): 1257 - 1264.
[Abstract] [Full Text]

Home page
 JEMHome page
L. Kari, A. Loboda, M. Nebozhyn, A. H. Rook, E. C. Vonderheid, C. Nichols, D. Virok, C. Chang, W.-H. Horng, J. Johnston, et al.
Classification and Prediction of Survival in Patients with the Leukemic Phase of Cutaneous T Cell Lymphoma
J. Exp. Med., June 2, 2003; 197(11): 1477 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Trembleau, G. Penna, S. Gregori, N. Giarratana, and L. Adorini
IL-12 Administration Accelerates Autoimmune Diabetes in Both Wild-Type and IFN-{gamma}-Deficient Nonobese Diabetic Mice, Revealing Pathogenic and Protective Effects of IL-12-Induced IFN-{gamma}
J. Immunol., June 1, 2003; 170(11): 5491 - 5501.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. M. Jensen, S. L. Meijer, R. A. Kurt, W. J. Urba, H.-M. Hu, and B. A. Fox
Regression of a Mammary Adenocarcinoma in STAT6-/- Mice Is Dependent on the Presence of STAT6-Reactive T Cells
J. Immunol., February 15, 2003; 170(4): 2014 - 2021.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Liu, B. E. Anderson, M. E. Robert, J. M. McNiff, S. G. Emerson, W. D. Shlomchik, and M. J. Shlomchik
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease
Blood, December 1, 2001; 98(12): 3367 - 3375.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. E. Curiel, C. S. Garcia, L. Farooq, M. F. Aguero, and I. Espinoza-Delgado
Bryostatin-1 and IL-2 Synergize to Induce IFN-{gamma} Expression in Human Peripheral Blood T Cells: Implications for Cancer Immunotherapy
J. Immunol., November 1, 2001; 167(9): 4828 - 4837.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
G. T. Tran, N. Carter, X. Y. He, T. S. Spicer, K. M. Plain, M. Nicolls, B. M. Hall, and S. J. Hodgkinson
Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4
Int. Immunol., September 1, 2001; 13(9): 1109 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Y. Zhang, R. Apilado, J. Coleman, S. Ben-Sasson, S. Tsang, J. Hu-Li, W. E. Paul, and H. Huang
Interferon {gamma} Stabilizes the T Helper Cell Type 1 Phenotype
J. Exp. Med., July 16, 2001; 194(2): 165 - 172.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Brewington, M. Chatterji, M. Zoubine, R. N. Miranda, M. Norimatsu, and A. Shnyra
IFN-{{gamma}}-Independent Autocrine Cytokine Regulatory Mechanism in Reprogramming of Macrophage Responses to Bacterial Lipopolysaccharide
J. Immunol., July 1, 2001; 167(1): 392 - 398.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. F. Halloran, L. W. Miller, J. Urmson, V. Ramassar, L.-F. Zhu, N. M. Kneteman, K. Solez, and M. Afrouzian
IFN-{{gamma}} Alters the Pathology of Graft Rejection: Protection from Early Necrosis
J. Immunol., June 15, 2001; 166(12): 7072 - 7081.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
L.A. Maier, R.T. Sawyer, S.S. Tinkle, L.A. Kittle, E.A. Barker, R. Balkissoon, C. Rose, and L.S. Newman
IL-4 fails to regulate in vitro beryllium-induced cytokines in berylliosis
Eur. Respir. J., March 1, 2001; 17(3): 403 - 415.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. E. Wigginton and D. Kirschner
A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis
J. Immunol., February 1, 2001; 166(3): 1951 - 1967.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J. D Cañete, S. E Martínez, J. Farrés, R. Sanmartí, M. Blay, A. Gómez, G. Salvador, and J. Muñoz-Gómez
Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies
Ann Rheum Dis, April 1, 2000; 59(4): 263 - 268.
[Abstract] [Full Text]

Home page
 BloodHome page
L. H. Wang, X. Y. Yang, R. A. Kirken, J. H. Resau, and W. L. Farrar
Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven TH2 cell response
Blood, February 15, 2000; 95(4): 1249 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. G. Doyle, K. Buttigieg, P. Groves, B. J. Johnson, and A. Kelso
The Activated Type 1-polarized CD8+ T Cell Population Isolated from an Effector Site Contains Cells with Flexible Cytokine Profiles
J. Exp. Med., October 18, 1999; 190(8): 1081 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. A. v. Wely, P. C. L. Beverley, S. J. Brett, C. J. Britten, and J. P. Tite
Expression of L-Selectin on Th1 Cells Is Regulated by IL-12
J. Immunol., August 1, 1999; 163(3): 1214 - 1221.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Lohning, J. L. Grogan, A. J. Coyle, M. Yazdanbakhsh, C. Meisel, J.-C. Gutierrez-Ramos, A. Radbruch, and T. Kamradt
T1/ST2 Expression Is Enhanced on CD4+ T Cells from Schistosome Egg-Induced Granulomas: Analysis of Th Cell Cytokine Coexpression Ex Vivo
J. Immunol., April 1, 1999; 162(7): 3882 - 3889.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. A. W. Skeiky, M. Kennedy, D. Kaufman, M. M. Borges, J. A. Guderian, J. K. Scholler, P. J. Ovendale, K. S. Picha, P. J. Morrissey, K. H. Grabstein, et al.
LeIF: A Recombinant Leishmania Protein That Induces an IL-12-Mediated Th1 Cytokine Profile
J. Immunol., December 1, 1998; 161(11): 6171 - 6179.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Mencacci, E. Cenci, G. D. Sero, C. Fe d'Ostiani, P. Mosci, G. Trinchieri, L. Adorini, and L. Romani
IL-10 Is Required for Development of Protective Th1 Responses in IL-12-Deficient Mice upon Candida albicans Infection
J. Immunol., December 1, 1998; 161(11): 6228 - 6237.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. E. Wakil, Z.-E. Wang, J. C. Ryan, D. J. Fowell, and R. M. Locksley
Interferon gamma  Derived from CD4+ T Cells Is Sufficient to Mediate T Helper Cell Type 1 Development
J. Exp. Med., November 2, 1998; 188(9): 1651 - 1656.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Kyuwa, Y.-i. Tagawa, S. Shibata, K. Doi, K. Machii, and Y. Iwakura
Murine Coronavirus-Induced Subacute Fatal Peritonitis in C57BL/6 Mice Deficient in Gamma Interferon
J. Virol., November 1, 1998; 72(11): 9286 - 9290.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Levite
Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype
PNAS, October 13, 1998; 95(21): 12544 - 12549.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Assenmacher, M. Lohning, A. Scheffold, A. Richter, S. Miltenyi, J. Schmitz, and A. Radbruch
Commitment of Individual Th1-Like Lymphocytes to Expression of IFN-{gamma} Versus IL-4 and IL-10: Selective Induction of IL-10 by Sequential Stimulation of Naive Th Cells with IL-12 and IL-4
J. Immunol., September 15, 1998; 161(6): 2825 - 2832.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-M. Hu, W. J. Urba, and B. A. Fox
Gene-Modified Tumor Vaccine with Therapeutic Potential Shifts Tumor-Specific T Cell Response from a Type 2 to a Type 1 Cytokine Profile
J. Immunol., September 15, 1998; 161(6): 3033 - 3041.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. T. Whary, T. J. Morgan, C. A. Dangler, K. J. Gaudes, N. S. Taylor, and J. G. Fox
Chronic Active Hepatitis Induced by Helicobacter hepaticus in the A/JCr Mouse Is Associated with a Th1 Cell-Mediated Immune Response
Infect. Immun., July 1, 1998; 66(7): 3142 - 3148.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. T. Miner and M. Croft
Generation, Persistence, and Modulation of Th0 Effector Cells: Role of Autocrine IL-4 and IFN-{gamma}
J. Immunol., June 1, 1998; 160(11): 5280 - 5287.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. J. Simpson, S. Shah, M. Comiskey, Y. P. de Jong, B. Wang, E. Mizoguchi, A. K. Bhan, and C. Terhorst
T Cell-mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon gamma  Expression by T Cells
J. Exp. Med., April 20, 1998; 187(8): 1225 - 1234.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Shnyra, R. Brewington, A. Alipio, C. Amura, and D. C. Morrison
Reprogramming of Lipopolysaccharide-Primed Macrophages Is Controlled by a Counterbalanced Production of IL-10 and IL-12
J. Immunol., April 15, 1998; 160(8): 3729 - 3736.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. Mencacci, G. Del Sero, E. Cenci, C. F. d'Ostiani, A. Bacci, C. Montagnoli, M. Kopf, and L. Romani
Endogenous Interleukin 4 Is Required for Development of Protective CD4+ T Helper Type 1 Cell Responses to Candida albicans
J. Exp. Med., February 2, 1998; 187(3): 307 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Piccotti, K. Li, S. Y. Chan, J. Ferrante, J. Magram, E. J. Eichwald, and D. K. Bishop
Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice
J. Immunol., February 1, 1998; 160(3): 1132 - 1138.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Cohn, R. J. Homer, A. Marinov, J. Rankin, and K. Bottomly
Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production
J. Exp. Med., November 17, 1997; 186(10): 1737 - 1747.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.