The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feltquate, D. M.
Right arrow Articles by Robinson, H. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feltquate, D. M.
Right arrow Articles by Robinson, H. L.

The Journal of Immunology, Vol 158, Issue 5 2278-2284, Copyright © 1997 by American Association of Immunologists

ARTICLES

Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization

DM Feltquate, S Heaney, RG Webster and HL Robinson
Department of Pathology, University of Massachusetts Medical School, Worcester 01655, USA.

Several routes and methods of DNA immunization have been shown to generate Ab, Th cells, and CTL responses. However, few studies have directly compared the immune responses generated by different routes and methods of DNA immunization. Utilizing an influenza hemagglutinin (H1)-expressing plasmid, we compared the immune response produced by saline injection of DNA into skin or muscle, and gene gun immunization of skin or muscle. We found that saline-DNA immunization raised a predominantly Th1 response with mostly IgG2a anti-H1 Ab, while gene gun DNA immunization produced a predominantly Th2 response with mostly IgG1 anti-H1 Abs. These distinct types of immune responses were generated by the method, not the route, of DNA immunization. The initial immunization established the Th cell-type of the immune response. The Th cell-type did not change with further DNA immunizations by the same or the alternate method, or after a viral challenge. The ability to generate different Th types was not due to differences in the doses of DNA used in saline and gene gun DNA immunization. These findings have important implications for vaccine design and studies of the mechanism of Th cell differentiation.


This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
W. Zhang, W. Li, Y. Li, H. Li, B. Wang, F. Wang, Y. Zhu, Z. Jiang, L. Zhong, and M. Li
Immune effects against influenza A virus and a novel DNA vaccine with co-expression of haemagglutinin- and neuraminidase-encoding genes
J. Med. Microbiol., July 1, 2009; 58(7): 845 - 854.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Yang, B. J. Whalen, R. S. Tirabassi, L. K. Selin, T. S. Levchenko, V. P. Torchilin, E. H. Kislauskis, and D. L. Guberski
A DNA Vaccine Prime Followed by a Liposome-Encapsulated Protein Boost Confers Enhanced Mucosal Immune Responses and Protection
J. Immunol., May 1, 2008; 180(9): 6159 - 6167.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
H. Hu, X. Lu, L. Tao, B. Bai, Z. Zhang, Y. Chen, F. Zheng, J. Chen, Z. Chen, and H. Wang
Induction of Specific Immune Responses by Severe Acute Respiratory Syndrome Coronavirus Spike DNA Vaccine with or without Interleukin-2 Immunization Using Different Vaccination Routes in Mice
Clin. Vaccine Immunol., July 1, 2007; 14(7): 894 - 901.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. R. Mathers, O. A. Tckacheva, B. M. Janelsins, W. J. Shufesky, A. E. Morelli, and A. T. Larregina
In Vivo Signaling through the Neurokinin 1 Receptor Favors Transgene Expression by Langerhans Cells and Promotes the Generation of Th1- and Tc1-Biased Immune Responses
J. Immunol., June 1, 2007; 178(11): 7006 - 7017.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
J. B. Alarcon, A. W. Hartley, N. G. Harvey, and J. A. Mikszta
Preclinical Evaluation of Microneedle Technology for Intradermal Delivery of Influenza Vaccines
Clin. Vaccine Immunol., April 1, 2007; 14(4): 375 - 381.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
V. C. Huber, R. M. McKeon, M. N. Brackin, L. A. Miller, R. Keating, S. A. Brown, N. Makarova, D. R. Perez, G. H. MacDonald, and J. A. McCullers
Distinct Contributions of Vaccine-Induced Immunoglobulin G1 (IgG1) and IgG2a Antibodies to Protective Immunity against Influenza.
Clin. Vaccine Immunol., September 1, 2006; 13(9): 981 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Luo, B. Ni, P. Li, W. Shi, S. Zhang, Y. Han, L. Mao, Y. He, Y. Wu, and X. Wang
Protective Immunity Elicited by a Divalent DNA Vaccine Encoding Both the L7/L12 and Omp16 Genes of Brucella abortus in BALB/c Mice.
Infect. Immun., May 1, 2006; 74(5): 2734 - 2741.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. V. E. Capozzo, K. Ramirez, J. M. Polo, J. Ulmer, E. M. Barry, M. M. Levine, and M. F. Pasetti
Neonatal Immunization with a Sindbis Virus-DNA Measles Vaccine Induces Adult-Like Neutralizing Antibodies and Cell-Mediated Immunity in the Presence of Maternal Antibodies
J. Immunol., May 1, 2006; 176(9): 5671 - 5681.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y.-S. Chen, Y.-S. Hsiao, H.-H. Lin, Y. Liu, and Y.-L. Chen
CpG-Modified Plasmid DNA Encoding Flagellin Improves Immunogenicity and Provides Protection against Burkholderia pseudomallei Infection in BALB/c Mice
Infect. Immun., March 1, 2006; 74(3): 1699 - 1705.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. E. Applequist, E. Rollman, M. D. Wareing, M. Liden, B. Rozell, J. Hinkula, and H.-G. Ljunggren
Activation of Innate Immunity, Inflammation, and Potentiation of DNA Vaccination through Mammalian Expression of the TLR5 Agonist Flagellin
J. Immunol., September 15, 2005; 175(6): 3882 - 3891.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
W. Mwangi, W. C. Brown, G. A. Splitter, Y. Zhuang, K. Kegerreis, and G. H. Palmer
Enhancement of antigen acquisition by dendritic cells and MHC class II-restricted epitope presentation to CD4+ T cells using VP22 DNA vaccine vectors that promote intercellular spreading following initial transfection
J. Leukoc. Biol., August 1, 2005; 78(2): 401 - 411.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. Zheng, L. A. Babiuk, and S. van Drunen Littel-van den Hurk
Bovine Herpesvirus 1 VP22 Enhances the Efficacy of a DNA Vaccine in Cattle
J. Virol., February 1, 2005; 79(3): 1948 - 1953.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Alvarez, G. Harder, R. Fattouh, J. Sun, S. Goncharova, M. R. Stampfli, A. J. Coyle, J. L. Bramson, and M. Jordana
Cutaneous Antigen Priming via Gene Gun Leads to Skin-Selective Th2 Immune-Inflammatory Responses
J. Immunol., February 1, 2005; 174(3): 1664 - 1674.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
B. Qu, R. N. Rosenberg, L. Li, P. J. Boyer, and S. A. Johnston
Gene Vaccination to Bias the Immune Response to Amyloid-{beta} Peptide as Therapy for Alzheimer Disease
Arch Neurol, December 1, 2004; 61(12): 1859 - 1864.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
C. Bartholdy, W. Olszewska, A. Stryhn, A. R. Thomsen, and P. J. M. Openshaw
Gene-gun DNA vaccination aggravates respiratory syncytial virus-induced pneumonitis
J. Gen. Virol., October 1, 2004; 85(10): 3017 - 3026.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Ramakrishna, K. K. Anand, K. M. Mohankumar, and U. Ranga
Codon Optimization of the Tat Antigen of Human Immunodeficiency Virus Type 1 Generates Strong Immune Responses in Mice following Genetic Immunization
J. Virol., September 1, 2004; 78(17): 9174 - 9189.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Garg, A. E. Oran, H. Hon, and J. Jacob
The Hybrid Cytomegalovirus Enhancer/Chicken {beta}-Actin Promoter along with Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances the Protective Efficacy of DNA Vaccines
J. Immunol., July 1, 2004; 173(1): 550 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Appl. Environ. Microbiol.Home page
J.-M. Chatel, S. Nouaille, K. Adel-Patient, Y. Le Loir, H. Boe, A. Gruss, J.-M. Wal, and P. Langella
Characterization of a Lactococcus lactis Strain That Secretes a Major Epitope of Bovine Beta-Lactoglobulin and Evaluation of Its Immunogenicity in Mice
Appl. Envir. Microbiol., November 1, 2003; 69(11): 6620 - 6627.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
N. A. Doria-Rose, C. Ohlen, P. Polacino, C. C. Pierce, M. T. Hensel, L. Kuller, T. Mulvania, D. Anderson, P. D. Greenberg, S.-L. Hu, et al.
Multigene DNA Priming-Boosting Vaccines Protect Macaques from Acute CD4+-T-Cell Depletion after Simian-Human Immunodeficiency Virus SHIV89.6P Mucosal Challenge
J. Virol., November 1, 2003; 77(21): 11563 - 11577.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Wang, D. M. Hone, A. Haddad, M. T. Shata, and D. W. Pascual
M Cell DNA Vaccination for CTL Immunity to HIV
J. Immunol., November 1, 2003; 171(9): 4717 - 4725.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
B. P. Nayak, G. Sailaja, and A. M. Jabbar
Enhancement of gp120-Specific Immune Responses by Genetic Vaccination with the Human Immunodeficiency Virus Type 1 Envelope Gene Fused to the Gene Coding for Soluble CTLA4
J. Virol., October 15, 2003; 77(20): 10850 - 10861.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. A. Onate, S. Cespedes, A. Cabrera, R. Rivers, A. Gonzalez, C. Munoz, H. Folch, and E. Andrews
A DNA Vaccine Encoding Cu,Zn Superoxide Dismutase of Brucella abortus Induces Protective Immunity in BALB/c Mice
Infect. Immun., September 1, 2003; 71(9): 4857 - 4861.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. E. Oran and H. L. Robinson
DNA Vaccines, Combining Form of Antigen and Method of Delivery to Raise a Spectrum of IFN-{gamma} and IL-4-Producing CD4+ and CD8+ T Cells
J. Immunol., August 15, 2003; 171(4): 1999 - 2005.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Z. Zhao, T. Wakita, and K. Yasui
Inoculation of Plasmids Encoding Japanese Encephalitis Virus PrM-E Proteins with Colloidal Gold Elicits a Protective Immune Response in BALB/c Mice
J. Virol., April 1, 2003; 77(7): 4248 - 4260.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
I. K. Srivastava and M. A. Liu
Gene Vaccines
Ann Intern Med, April 1, 2003; 138(7): 550 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y.-L. Chen, S.-N. Wang, W.-J. Yang, Y.-J. Chen, H.-H. Lin, and D. Shiuan
Expression and Immunogenicity of Mycoplasma hyopneumoniae Heat Shock Protein Antigen P42 by DNA Vaccination
Infect. Immun., March 1, 2003; 71(3): 1155 - 1160.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. Grosfeld, S. Cohen, T. Bino, Y. Flashner, R. Ber, E. Mamroud, C. Kronman, A. Shafferman, and B. Velan
Effective Protective Immunity to Yersinia pestis Infection Conferred by DNA Vaccine Coding for Derivatives of the F1 Capsular Antigen
Infect. Immun., January 1, 2003; 71(1): 374 - 383.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Rush, T. Mitchell, and P. Garside
Efficient Priming of CD4+ and CD8+ T Cells by DNA Vaccination Depends on Appropriate Targeting of Sufficient Levels of Immunologically Relevant Antigen to Appropriate Processing Pathways
J. Immunol., November 1, 2002; 169(9): 4951 - 4960.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Sasaki, R. R. Amara, W.-S. Yeow, P. M. Pitha, and H. L. Robinson
Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
J. Virol., June 5, 2002; 76(13): 6652 - 6659.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. A. Velikovsky, J. Cassataro, G. H. Giambartolomei, F. A. Goldbaum, S. Estein, R. A. Bowden, L. Bruno, C. A. Fossati, and M. Spitz
A DNA Vaccine Encoding Lumazine Synthase from Brucella abortus Induces Protective Immunity in BALB/c Mice
Infect. Immun., May 1, 2002; 70(5): 2507 - 2511.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
A. M. Pilling, R. M. Harman, S. A. Jones, N. A.M. Mccormack, D. Lavender, and R. Haworth
The Assessment of Local Tolerance, Acute Toxicity, and DNA Biodistribution Following Particle-Mediated Delivery of a DNA Vaccine to Minipigs
Toxicol Pathol, April 1, 2002; 30(3): 298 - 305.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
P. Pichurin, O. Pichurina, G. D. Chazenbalk, C. Paras, C.-R. Chen, B. Rapoport, and S. M. McLachlan
Immune Deviation Away from Th1 in Interferon-{gamma} Knockout Mice Does Not Enhance TSH Receptor Antibody Production after Naked DNA Vaccination
Endocrinology, April 1, 2002; 143(4): 1182 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
K. Haupt, M. Roggendorf, and K. Mann
The Potential of DNA Vaccination against Tumor-Associated Antigens for Antitumor Therapy
Experimental Biology and Medicine, April 1, 2002; 227(4): 227 - 237.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Arrington, R. P. Braun, L. Dong, D. H. Fuller, M. D. Macklin, S. W. Umlauf, S. J. Wagner, M. S. Wu, L. G. Payne, and J. R. Haynes
Plasmid Vectors Encoding Cholera Toxin or the Heat-Labile Enterotoxin from Escherichia coli Are Strong Adjuvants for DNA Vaccines
J. Virol., March 27, 2002; 76(9): 4536 - 4546.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. Satoi, K. Murata, M. Lechmann, E. Manickan, Z. Zhang, H. Wedemeyer, B. Rehermann, and T. J. Liang
Genetic Immunization of Wild-Type and Hepatitis C Virus Transgenic Mice Reveals a Hierarchy of Cellular Immune Response and Tolerance Induction against Hepatitis C Virus Structural Proteins
J. Virol., December 15, 2001; 75(24): 12121 - 12127.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Hel, W.-P. Tsai, A. Thornton, J. Nacsa, L. Giuliani, E. Tryniszewska, M. Poudyal, D. Venzon, X. Wang, J. Altman, et al.
Potentiation of Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cell Responses by a DNA-SIV and NYVAC-SIV Prime/Boost Regimen
J. Immunol., December 15, 2001; 167(12): 7180 - 7191.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Deml, A. Bojak, S. Steck, M. Graf, J. Wild, R. Schirmbeck, H. Wolf, and R. Wagner
Multiple Effects of Codon Usage Optimization on Expression and Immunogenicity of DNA Candidate Vaccines Encoding the Human Immunodeficiency Virus Type 1 Gag Protein
J. Virol., November 15, 2001; 75(22): 10991 - 11001.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. H. Cho, J. W. Youn, and Y. C. Sung
Cross-Priming as a Predominant Mechanism for Inducing CD8+ T Cell Responses in Gene Gun DNA Immunization
J. Immunol., November 15, 2001; 167(10): 5549 - 5557.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Pichurin, X.-M. Yan, L. Farilla, J. Guo, G. D. Chazenbalk, B. Rapoport, and S. M. McLachlan
Naked TSH Receptor DNA Vaccination: A TH1 T Cell Response in Which Interferon-{gamma} Production, Rather than Antibody, Dominates the Immune Response in Mice
Endocrinology, August 1, 2001; 142(8): 3530 - 3536.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Wu, X. Wang, K. L. Csencsits, A. Haddad, N. Walters, and D. W. Pascual
M cell-targeted DNA vaccination
PNAS, July 13, 2001; (2001) 161204098.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. M. Price, A. L. Liner, S. Park, S. H. Leppla, A. Mateczun, and D. R. Galloway
Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein
Infect. Immun., July 1, 2001; 69(7): 4509 - 4515.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. J. Weaver Jr., B. Liu, and R. Tisch
Plasmid DNAs Encoding Insulin and Glutamic Acid Decarboxylase 65 Have Distinct Effects on the Progression of Autoimmune Diabetes in Nonobese Diabetic Mice
J. Immunol., July 1, 2001; 167(1): 586 - 592.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Li, J.-J. Yu, C.-Y. Hung, P. F. Lehmann, and G. T. Cole
Recombinant Urease and Urease DNA of Coccidioides immitis Elicit an Immunoprotective Response against Coccidioidomycosis in Mice
Infect. Immun., May 1, 2001; 69(5): 2878 - 2887.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. Haupt, F. Siegel, M. Lu, D. Yang, G. Hilken, K. Mann, M. Roggendorf, and B. Saller
Induction of a Cellular and Humoral Immune Response against Preprocalcitonin by Genetic Immunization: A Potential New Treatment for Medullary Thyroid Carcinoma
Endocrinology, March 1, 2001; 142(3): 1017 - 1023.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Tisch, B. Wang, D. J. Weaver, B. Liu, T. Bui, J. Arthos, and D. V. Serreze
Antigen-Specific Mediated Suppression of {{beta}} Cell Autoimmunity by Plasmid DNA Vaccination
J. Immunol., February 1, 2001; 166(3): 2122 - 2132.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Ohashi, S. Hanabuchi, H. Kato, H. Tateno, F. Takemura, T. Tsukahara, Y. Koya, A. Hasegawa, T. Masuda, and M. Kannagi
Prevention of Adult T-Cell Leukemia-Like Lymphoproliferative Disease in Rats by Adoptively Transferred T Cells from a Donor Immunized with Human T-Cell Leukemia Virus Type 1 Tax-Coding DNA Vaccine
J. Virol., October 15, 2000; 74(20): 9610 - 9616.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
R. Weiss, W. W. Leitner, S. Scheiblhofer, D. Chen, A. Bernhaupt, S. Mostbock, J. Thalhamer, and J. A. Lyon
Genetic Vaccination against Malaria Infection by Intradermal and Epidermal Injections of a Plasmid Containing the Gene Encoding the Plasmodium berghei Circumsporozoite Protein
Infect. Immun., October 1, 2000; 68(10): 5914 - 5919.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
G. P. Bembridge, N. Rodriguez, R. Garcia-Beato, C. Nicolson, J. A. Melero, and G. Taylor
DNA encoding the attachment (G) or fusion (F) protein of respiratory syncytial virus induces protection in the absence of pulmonary inflammation
J. Gen. Virol., October 1, 2000; 81(10): 2519 - 2523.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
T. M. Pertmer, A. E. Oran, J. M. Moser, C. A. Madorin, and H. L. Robinson
DNA Vaccines for Influenza Virus: Differential Effects of Maternal Antibody on Immune Responses to Hemagglutinin and Nucleoprotein
J. Virol., September 1, 2000; 74(17): 7787 - 7793.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
A. Tanghe, O. Denis, B. Lambrecht, V. Motte, T. van den Berg, and K. Huygen
Tuberculosis DNA Vaccine Encoding Ag85A Is Immunogenic and Protective When Administered by Intramuscular Needle Injection but Not by Epidermal Gene Gun Bombardment
Infect. Immun., July 1, 2000; 68(7): 3854 - 3860.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
P. A. Johnson, M. A. Conway, J. Daly, C. Nicolson, J. Robertson, and K. H. G. Mills
Plasmid DNA encoding influenza virus haemagglutinin induces Th1 cells and protection against respiratory infection despite its limited ability to generate antibody responses
J. Gen. Virol., July 1, 2000; 81(7): 1737 - 1745.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
S. Pepperl, J. Münster, M. Mach, J. R. Harris, and B. Plachter
Dense Bodies of Human Cytomegalovirus Induce both Humoral and Cellular Immune Responses in the Absence of Viral Gene Expression
J. Virol., July 1, 2000; 74(13): 6132 - 6146.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
A. La Cava, R. Billetta, G. Gaietta, D. B. Bonnin, S. M. Baird, and S. Albani
Cell-Mediated DNA Transport Between Distant Inflammatory Sites Following Intradermal DNA Immunization in the Presence of Adjuvant
J. Immunol., February 1, 2000; 164(3): 1340 - 1345.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. H. Aberle, S. W. Aberle, S. L. Allison, K. Stiasny, M. Ecker, C. W. Mandl, R. Berger, and F. X. Heinz
A DNA Immunization Model Study with Constructs Expressing the Tick-Borne Encephalitis Virus Envelope Protein E in Different Physical Forms
J. Immunol., December 15, 1999; 163(12): 6756 - 6761.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H.-W. Chen, C.-H. Pan, M.-Y. Liau, R. Jou, C.-J. Tsai, H.-J. Wu, Y.-L. Lin, and M.-H. Tao
Screening of Protective Antigens of Japanese Encephalitis Virus by DNA Immunization: a Comparative Study with Conventional Viral Vaccines
J. Virol., December 1, 1999; 73(12): 10137 - 10145.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
P. J. Lewis, S. van Drunen Littel-van den Hurk, and L. A. Babiuk
Altering the Cellular Location of an Antigen Expressed by a DNA-Based Vaccine Modulates the Immune Response
J. Virol., December 1, 1999; 73(12): 10214 - 10223.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. Charo, A.-M. T. Ciupitu, A. Le Chevalier de Preville, P. Trivedi, G. Klein, J. Hinkula, and R. Kiessling
A Long-Term Memory Obtained by Genetic Immunization Results in Full Protection from a Mammary Adenocarcinoma Expressing an EBV Gene
J. Immunol., December 1, 1999; 163(11): 5913 - 5919.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Corr, A. von Damm, D. J. Lee, and H. Tighe
In Vivo Priming by DNA Injection Occurs Predominantly by Antigen Transfer
J. Immunol., November 1, 1999; 163(9): 4721 - 4727.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Fensterle, L. Grode, J. Hess, and S. H. E. Kaufmann
Effective DNA Vaccination Against Listeriosis by Prime/Boost Inoculation with the Gene Gun
J. Immunol., October 15, 1999; 163(8): 4510 - 4518.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. A. Belperron, D. Feltquate, B. A. Fox, T. Horii, and D. J. Bzik
Immune Responses Induced by Gene Gun or Intramuscular Injection of DNA Vaccines That Express Immunogenic Regions of the Serine Repeat Antigen from Plasmodium falciparum
Infect. Immun., October 1, 1999; 67(10): 5163 - 5169.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
Z. Chen, T. Yoshikawa, S.-e. Kadowaki, Y. Hagiwara, K. Matsuo, H. Asanuma, C. Aizawa, T. Kurata, and S.-i. Tamura
Protection and antibody responses in different strains of mouse immunized with plasmid DNAs encoding influenza virus haemagglutinin, neuraminidase and nucleoprotein
J. Gen. Virol., October 1, 1999; 80(10): 2559 - 2564.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. Watanabe, R. G. Fenton, J. M. Wigginton, K. L. McCormick, K. M. Volker, W. E. Fogler, P. G. Roessler, and R. H. Wiltrout
Intradermal Delivery of IL-12 Naked DNA Induces Systemic NK Cell Activation and Th1 Response In Vivo That Is Independent of Endogenous IL-12 Production
J. Immunol., August 15, 1999; 163(4): 1943 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. M. Rodrigues, M. Ribeirao, V. Pereira-Chioccola, L. Renia, and F. Costa
Predominance of CD4 Th1 and CD8 Tc1 Cells Revealed by Characterization of the Cellular Immune Response Generated by Immunization with a DNA Vaccine Containing a Trypanosoma cruzi Gene
Infect. Immun., August 1, 1999; 67(8): 3855 - 3863.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Arulkanthan, W. C. Brown, T. C. McGuire, and D. P. Knowles
Biased Immunoglobulin G1 Isotype Responses Induced in Cattle with DNA Expressing msp1a of Anaplasma marginale
Infect. Immun., July 1, 1999; 67(7): 3481 - 3487.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. J. Verschoor, P. Mooij, H. Oostermeijer, M. van der Kolk, P. ten Haaft, B. Verstrepen, Y. Sun, B. Morein, L. Åkerblom, D. H. Fuller, et al.
Comparison of Immunity Generated by Nucleic Acid-, MF59-, and ISCOM-Formulated Human Immunodeficiency Virus Type 1 Vaccines in Rhesus Macaques: Evidence for Viral Clearance
J. Virol., April 1, 1999; 73(4): 3292 - 3300.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
X.-m. Li, C.-K. Huang, B. H. Schofield, A. W. Burks, G. A. Bannon, K.-H. Kim, S.-K. Huang, and H. A. Sampson
Strain-Dependent Induction of Allergic Sensitization Caused by Peanut Allergen DNA Immunization in Mice
J. Immunol., March 1, 1999; 162(5): 3045 - 3052.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Lu, G. Hilken, J. Kruppenbacher, T. Kemper, R. Schirmbeck, J. Reimann, and M. Roggendorf
Immunization of Woodchucks with Plasmids Expressing Woodchuck Hepatitis Virus (WHV) Core Antigen and Surface Antigen Suppresses WHV Infection
J. Virol., January 1, 1999; 73(1): 281 - 289.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Adam. D. Cohen, J. D. Boyer, and D. B. Weiner
Modulating the immune response to genetic immunization
FASEB J, December 1, 1998; 12(15): 1611 - 1626.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
N. Sixt, A. Cardoso, A. Vallier, J. Fayolle, R. Buckland, and T. F. Wild
Canine Distemper Virus DNA Vaccination Induces Humoral and Cellular Immunity and Protects against a Lethal Intracerebral Challenge
J. Virol., November 1, 1998; 72(11): 8472 - 8476.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. W. Lee, J. H. Cho, and Y. C. Sung
Optimal Induction of Hepatitis C Virus Envelope-Specific Immunity by Bicistronic Plasmid DNA Inoculation with the Granulocyte-Macrophage Colony-Stimulating Factor Gene
J. Virol., October 1, 1998; 72(10): 8430 - 8436.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Schmolke, M. Tacke, U. Schmitt, A. M. Engel, and B. Ofenloch-Haehnle
Identification of Hepatitis G Virus Particles in Human Serum by E2-Specific Monoclonal Antibodies Generated by DNA Immunization
J. Virol., May 1, 1998; 72(5): 4541 - 4545.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. H. Horspool, P. J. Perrin, J. B. Woodcock, J. H. Cox, C. L. King, C. H. June, D. M. Harlan, D. C. St. Louis, and K. P. Lee
Nucleic Acid Vaccine-Induced Immune Responses Require CD28 Costimulation and Are Regulated by CTLA4
J. Immunol., March 15, 1998; 160(6): 2706 - 2714.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. I. Cardoso, N. Sixt, A. Vallier, J. Fayolle, R. Buckland, and T. F. Wild
Measles Virus DNA Vaccination: Antibody Isotype Is Determined by the Method of Immunization and by the Nature of both the Antigen and the Coimmunized Antigen
J. Virol., March 1, 1998; 72(3): 2516 - 2518.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. S. Boyle, A. Silva, J. L. Brady, and A. M. Lew
DNA immunization: Induction of higher avidity antibody and effect of route on T cell cytotoxicity
PNAS, December 23, 1997; 94(26): 14626 - 14631.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Gurunathan, D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder
Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania major
J. Exp. Med., October 6, 1997; 186(7): 1137 - 1147.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Wu, X. Wang, K. L. Csencsits, A. Haddad, N. Walters, and D. W. Pascual
M cell-targeted DNA vaccination
PNAS, July 31, 2001; 98(16): 9318 - 9323.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.