| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 158, Issue 3 1078-1084, Copyright © 1997 by American Association of Immunologists
ARTICLES |
CB Marsh, MD Wewers, LC Tan and BH Rovin
Division of Pulmonary and Critical Care Medicine, Ohio State University, Columbus 43210, USA.
Immune complexes activate cells by cross-linking leukocyte surface Fc(gamma)Rs. Diseases associated with immune complex deposition, such as rheumatoid arthritis, glomerulonephritis, or idiopathic pulmonary fibrosis, are characterized by compartmentalized monocyte infiltration. The factors that recruit monocytes to these compartments are not well characterized; however, monocyte chemoattractant protein-1 (MCP-1) has been found in areas of tissue injury. To account for these observations we hypothesized that PBMC Fc(gamma)R cross-linking may induce MCP-1 synthesis, which stimulates further monocyte recruitment. To test this hypothesis, PBMC were incubated on increasing concentrations of immobilized human IgG, a stimulus for Fc(gamma)R cross-linking. Immunoreactive MCP-1 was produced in a dose-dependent manner (p < 0.0001). MCP-1 was specifically induced by Fc(gamma)R cross-linking, since immobilized F(ab')2 fragments of human IgG did not activate MCP-1 production. This effect was reproduced by directly cross-linking PBMC Fc(gamma)RIII, but not by cross-linking Fc(gamma)RI or Fc(gamma)RII. PBMC-derived MCP-1 stimulated monocyte chemotaxis that was inhibited by a neutralizing anti-MCP-1 Ab. MCP-1 levels correlated with increased PBMC mRNA expression. Interestingly, Fc(gamma)R cross-linking with either immobilized IgG or anti-Fc(gamma)RIII induced more MCP-1 release from PBMC than from autologous monocytes (p = 0.02). Lymphocytes, the main cell type found in PBMC preparations, did not independently produce a significant amount of MCP-1, but when incubated on immobilized IgG or anti-Fc(gamma)RIII secreted a soluble factor(s) that induced monocyte MCP-1 production. These data suggest that cross- linking PBMC Fc(gamma)R induces the production of bioactive MCP-1. This occurs in part at the level of gene transcription and involves a cooperative interaction between monocytes and lymphocytes.
This article has been cited by other articles:
|
|
 |
|
  J. Wehner, C. N. Morrell, T. Reynolds, E. R. Rodriguez, and W. M. Baldwin III Antibody and Complement in Transplant Vasculopathy Circ. Res., February 2, 2007; 100(2): 191 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Braselmann, V. Taylor, H. Zhao, S. Wang, C. Sylvain, M. Baluom, K. Qu, E. Herlaar, A. Lau, C. Young, et al. R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 998 - 1008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Woelbing, S. L. Kostka, K. Moelle, Y. Belkaid, C. Sunderkoetter, S. Verbeek, A. Waisman, A. P. Nigg, J. Knop, M. C. Udey, et al. Uptake of Leishmania major by dendritic cells is mediated by Fc{gamma} receptors and facilitates acquisition of protective immunity J. Exp. Med., January 23, 2006; 203(1): 177 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. M. Wu, M. Jin, and C. B. Marsh Toward functional proteomics of alveolar macrophages Am J Physiol Lung Cell Mol Physiol, April 1, 2005; 288(4): L585 - L595. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Casadevall and L.-a. Pirofski New Concepts in Antibody-Mediated Immunity Infect. Immun., November 1, 2004; 72(11): 6191 - 6196. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tridandapani, R. Wardrop, C. P. Baran, Y. Wang, J. M. Opalek, M. A. Caligiuri, and C. B. Marsh TGF-{beta}1 Suppresses Myeloid Fc{gamma} Receptor Function by Regulating the Expression and Function of the Common {gamma}-Subunit J. Immunol., May 1, 2003; 170(9): 4572 - 4577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. Morgan, V. H. Keyte, S. J. Babbage, J. I. Robinson, F. Ponchel, J. H. Barrett, B. B. Bhakta, S. J. Bingham, M. H. Buch, P. G. Conaghan, et al. Fc{gamma}RIIIA-158V and rheumatoid arthritis: a confirmation study Rheumatology, April 1, 2003; 42(4): 528 - 533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Colmenares, S. L. Constant, P. E. Kima, and D. McMahon-Pratt Leishmania pifanoi Pathogenesis: Selective Lack of a Local Cutaneous Response in the Absence of Circulating Antibody Infect. Immun., December 1, 2002; 70(12): 6597 - 6605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Kaplan, S. K. O'Neill, T. Koreny, M. Czipri, and A. Finnegan Development of Inflammation in Proteoglycan-Induced Arthritis Is Dependent on Fc{gamma}R Regulation of the Cytokine/Chemokine Environment J. Immunol., November 15, 2002; 169(10): 5851 - 5859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Drechsler, S. Chavan, D. Catalano, P. Mandrekar, and G. Szabo Fc{gamma}R cross-linking mediates NF-{kappa}B activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development J. Leukoc. Biol., October 1, 2002; 72(4): 657 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Rovin, L. Lu, and C. B. Marsh Lymphocytes induce monocyte chemoattractant protein-1 production by renal cells after Fc{gamma} receptor cross-linking: role of IL-1{beta} J. Leukoc. Biol., March 1, 2001; 69(3): 435 - 439. [Abstract] [Full Text]
|
|
|
|
|
|
A. V. Andjelkovic, D. Kerkovich, and J. S. Pachter Monocyte:astrocyte interactions regulate MCP-1 expression in both cell types J. Leukoc. Biol., October 1, 2000; 68(4): 545 - 552. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kleinau, P. Martinsson, and B. Heyman Induction and Suppression of Collagen-induced Arthritis Is Dependent on Distinct Fc{gamma} Receptors J. Exp. Med., May 1, 2000; 191(9): 1611 - 1616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Lendvai, X.-W. Qu, W. Hsueh, and A. Casadevall Mechanism for the Isotype Dependence of Antibody-Mediated Toxicity in Cryptococcus neoformans-Infected Mice J. Immunol., April 15, 2000; 164(8): 4367 - 4374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Alonso, Y. Bayon, M. Renedo, and M. S. Crespo Stimulation of Fc{gamma}R receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving I{kappa}B-{alpha} degradation and formation of p50/p65 NF-{kappa}B/Rel complexes Int. Immunol., April 1, 2000; 12(4): 547 - 554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Marsh, R. P. Pomerantz, J. M. Parker, A. V. Winnard, E. L. Mazzaferri Jr., N. Moldovan, T. W. Kelley, E. Beck, and M. D. Wewers Regulation of Monocyte Survival In Vitro by Deposited IgG: Role of Macrophage Colony-Stimulating Factor J. Immunol., May 15, 1999; 162(10): 6217 - 6225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. H. Richard, P. W. Gudewicz, and D. J. Loegering IgG-coated erythrocytes augment the lipopolysaccharidestimulated increase in serum tumor necrosis factor-alpha Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R171 - R177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. B. Marsh, M. P. Lowe, B. H. Rovin, J. M. Parker, Z. Liao, D. L. Knoell, and M. D. Wewers Lymphocytes Produce IL-1{beta} in Response to Fc{gamma} Receptor Cross-Linking: Effects on Parenchymal Cell IL-8 Release J. Immunol., April 15, 1998; 160(8): 3942 - 3948. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
