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The Journal of Immunology, Vol 158, Issue 3 1041-1050, Copyright © 1997 by American Association of Immunologists

ARTICLES

CD8 alphabeta+ TCR alphabeta(intermediate) lymphocytes expressing skewed TCRVbeta repertoire in the liver of aged athymic nu/nu mice

M Emoto, Y Emoto and SH Kaufmann
Department of Immunology, University of Ulm, Germany.

Principally, TCRalphabeta cells differentiate and mature in the thymus. However, evidence has accumulated to suggest that some TCRalphabeta cells develop extrathymically. Such cells have been identified in athymic nu/nu mice that are devoid of a functional thymus. They appear relatively late in ontogeny and randomly increase in number as a function of age. Recently, the liver has been suggested as a candidate site for thymus-independent development of T cells. Here we show that CD8alphabeta+ T cells that express TCRalphabeta at intermediate intensity (TCRalpha(beta)int) are preferentially localized in the liver of nu/nu mice. This population encompassed cells expressing lectin cell adhesion molecule-1 and/or IL-2Rbeta and cells lacking either of these surface molecules. The CD8alphabeta+ TCRalpha(beta)int liver lymphocytes in nu/nu mice also differed in their LFA-1 expression marginally, whereas in C57BL/6 mice all CD8alphabeta+ TCRalpha(beta)int liver lymphocytes expressed LFA-1 at low intensity. Although the TCRVbeta repertoire markedly differed among individual animals, the CD8alphabeta+ TCRalpha(beta)int liver lymphocytes in nu/nu mice preferentially used TCRVbeta5 and/or TCRVbeta8. These findings show that CD8alphabeta+ TCRalpha(beta)int cells develop in the liver of nu/nu mice and that they arise randomly.


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