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The Journal of Immunology, Vol 158, Issue 2 649-657, Copyright © 1997 by American Association of Immunologists

ARTICLES

Visualization of antigen-specific T cell activation and cytokine expression in vivo

WO Rogers, CT Weaver, LA Kraus, J Li, L Li and RP Bucy
Department of Pathology, University of Alabama at Birmingham, 35233, USA.

A transgenic TCR adoptive transfer system was used to visualize Ag- specific T cell activation and cytokine expression in vivo. After s.c. injection of peptide in adjuvant the entire Ag-specific population up- regulated IL-2 receptor alpha-chain expression, underwent blast transformation, and developed a memory-surface phenotype. A minority of the Ag-specific T cells produced predominantly IL-2 mRNA and localized at the T cell/B cell junction in draining lymph nodes. In the secondary response, a mixed cytokine pattern of both Th1 and Th2 cytokines was demonstrated. When peptide was administered i.v. without adjuvant, 50% of the Ag-specific cells expressed IL-2, but the peak of expression occurred before IL-2 receptor alpha-chain up-regulation, and only a minority of the Ag-specific T cells underwent blast transformation.


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