| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 158, Issue 2 598-603, Copyright © 1997 by American Association of Immunologists
ARTICLES |
RH Lin, YW Hwang, BC Yang and CS Lin
Graduate Institute of Immunology, College of Medicine, National Taiwan University, Taipei, Republic of China.
Stimulation of recently activated T cells results in apoptosis of the responding cells, a process referred to as activation-induced cell death. This process is believed to play an important role in the regulation of immune homeostasis and is suggested to be mediated mainly by interactions between Fas and Fas ligand. Recent evidence indicates that TNF-alpha and TNFR2 interaction plays an important role in down- regulating activated T cells. The role of TNFR2 signaling in activation- induced cell death, however, has not been directly examined. We demonstrate here that 48-h activated T cells are most sensitive to TNFR2-induced apoptosis. Cross-linking of TNFR2 on activated T cells results in down-regulated protein and mRNA expression of Bcl-xL. Furthermore, CD28 costimulation can prevent anti-TNFR2-induced apoptosis and restore Bcl-xL expression. These results have potential implications for understanding the role of TNFR2 signaling in the regulation of T cell responses.
This article has been cited by other articles:
|
|
 |
|
  Y. Monden, T. Kubota, T. Inoue, T. Tsutsumi, S. Kawano, T. Ide, H. Tsutsui, and K. Sunagawa Tumor necrosis factor-{alpha} is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H743 - H753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Papasavvas, J. Sun, Q. Luo, E. C. Moore, B. Thiel, R. R. MacGregor, A. Minty, K. Mounzer, J. R. Kostman, and L. J. Montaner IL-13 Acutely Augments HIV-Specific and Recall Responses from HIV-1-Infected Subjects In Vitro by Modulating Monocytes J. Immunol., October 15, 2005; 175(8): 5532 - 5540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Chen, Z. Tong, Q. Ye, S. Nakamura, U. Costabel, and J. Guzman Expression of tumour necrosis factor receptors by bronchoalveolar cells in hypersensitivity pneumonitis Eur. Respir. J., June 1, 2005; 25(6): 1039 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Gonzalez, A. Orlofsky, and M. B. Prystowsky A1 is a growth-permissive antiapoptotic factor mediating postactivation survival in T cells Blood, April 1, 2003; 101(7): 2679 - 2685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bureau, A. Vanderplasschen, F. Jaspar, F. Minner, P.-P. Pastoret, M.-P. Merville, V. Bours, and P. Lekeux Constitutive nuclear factor-kappa B activity preserves homeostasis of quiescent mature lymphocytes and granulocytes by controlling the expression of distinct Bcl-2 family proteins Blood, May 15, 2002; 99(10): 3683 - 3691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. de Oliveira Pinto, S. Garcia, H. Lecoeur, C. Rapp, and M.-L. Gougeon Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3 Blood, March 1, 2002; 99(5): 1666 - 1675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Pettersen, G. Bernard, M. K. Olafsen, M. Pourtein, and S. O. Lie CD99 Signals Caspase-Independent T Cell Death J. Immunol., April 15, 2001; 166(8): 4931 - 4942. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. H. J. M. PIJPERS, P. A. V. SETTEN, L. P. W. J. V. D. HEUVEL, K. J. M. ASSMANN, H. B. P. M. DIJKMAN, A. H. M. PENNINGS, L. A. H. MONNENS, and V. W. M. V. HINSBERGH Verocytotoxin-Induced Apoptosis of Human Microvascular Endothelial Cells J. Am. Soc. Nephrol., April 1, 2001; 12(4): 767 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Khoshnan, C. Tindell, I. Laux, D. Bae, B. Bennett, and A. E. Nel The NF-{kappa}B Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes J. Immunol., August 15, 2000; 165(4): 1743 - 1754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Herbein and W. A. O'brien Tumor Necrosis Factor (TNF)-{alpha} and TNF Receptors in Viral Pathogenesis Experimental Biology and Medicine, March 1, 2000; 223(3): 241 - 257. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Bertolino, M.-C. Trescol-Biemont, J. Thomas, B. F. de St Groth, M. Pihlgren, J. Marvel, and C. Rabourdin-Combe Death by neglect as a deletional mechanism of peripheral tolerance Int. Immunol., August 1, 1999; 11(8): 1225 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Pettersen, K. Hestdal, M. K. Olafsen, S. O. Lie, and F. P. Lindberg CD47 Signals T Cell Death J. Immunol., June 15, 1999; 162(12): 7031 - 7040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, A.-K. Somani, S. Watt, G. B. Mills, and K. A. Siminovitch The Src-Homology Domain 2-Bearing Protein Tyrosine Phosphatase-1 Inhibits Antigen Receptor-Induced Apoptosis of Activated Peripheral T Cells J. Immunol., June 1, 1999; 162(11): 6359 - 6367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Khan, J. M. Penninger, L. Yang, L. E. Marra, I. Kozieradzki, and L. Zhang Regulation of Apoptosis in Mature {alpha}{beta}+CD4-CD8- Antigen-Specific Suppressor T Cell Clones J. Immunol., May 15, 1999; 162(10): 5860 - 5867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Zhuang, B. Wang, G. A. Shinder, G. M. Shivji, T. W. Mak, and D. N. Sauder TNF Receptor p55 Plays a Pivotal Role in Murine Keratinocyte Apoptosis Induced by Ultraviolet B Irradiation J. Immunol., February 1, 1999; 162(3): 1440 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Harrop, M. Reddy, K. Dede, M. Brigham-Burke, S. Lyn, K. B. Tan, C. Silverman, C. Eichman, R. DiPrinzio, J. Spampanato, et al. Antibodies to TR2 (Herpesvirus Entry Mediator), a New Member of the TNF Receptor Superfamily, Block T Cell Proliferation, Expression of Activation Markers, and Production of Cytokines J. Immunol., August 15, 1998; 161(4): 1786 - 1794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Collette, A. Benziane, D. Razanajaona, and D. Olive Distinct Regulation of T-Cell Death by CD28 Depending on Both Its Aggregation and T-Cell Receptor Triggering: A Role for Fas-FasL Blood, August 15, 1998; 92(4): 1350 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Deckert-Schluter, H. Bluethmann, A. Rang, H. Hof, and D. Schluter Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis J. Immunol., April 1, 1998; 160(7): 3427 - 3436. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ruby, H. Bluethmann, and J. J. Peschon Antiviral Activity of Tumor Necrosis Factor (TNF) Is Mediated via p55 and p75 TNF Receptors J. Exp. Med., November 3, 1997; 186(9): 1591 - 1596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Masuda, T. Matsuguchi, K. Yamaki, T. Hayakawa, and Y. Yoshikai Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression J. Biol. Chem., July 6, 2001; 276(28): 26107 - 26113. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
