The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lu, L.
Right arrow Articles by Thomson, A. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lu, L.
Right arrow Articles by Thomson, A. W.

The Journal of Immunology, Vol 158, Issue 12 5676-5684, Copyright © 1997 by American Association of Immunologists

ARTICLES

Fas ligand (CD95L) and B7 expression on dendritic cells provide counter- regulatory signals for T cell survival and proliferation

L Lu, S Qian, PA Hershberger, WA Rudert, DH Lynch and AW Thomson
Thomas E. Starzl Transplantation Institute and the Department of Surgery, University of Pittsburgh, PA 15213, USA.

Activation of T cells is induced efficiently by dendritic cells (DC), but little is known about the role of DC in the regulation of T cell death. In this study, highly purified DC (DEC-205+, MHC class II(high), B7-1+ [CD80+], B7-2high [CD86high], CD40+, CD11c+) grown from normal mouse bone marrow in granulocyte-macrophage CSF + IL-4 were found to express FasL (CD95L) mRNA by reverse transcriptase PCR and to uniformly express FasL by both flow cytometric and immunocytochemical analyses. These cells, but not DC propagated from FasL-deficient (B6.gld) mice, induced dose-dependent increases in DNA fragmentation in Fas+ Jurkat T cells over 18 h coculture. Addition of mouse Fas-Fc fusion protein at the start of the cultures diminished this effect. Even at high relative concentrations, however, B7-2high DC induced only low levels of DNA fragmentation in Con A or alloactivated splenic T cells, as determined by radio- or spectrofluorometric assays and by in situ nick-end labeling. However, in the presence of CTLA4Ig, a molecule that blocks the B7-CD28 costimulatory pathway, DC that failed to stimulate in primary MLR induced markedly augmented levels of apoptosis in alloactivated T cells. CTLA4Ig treatment also increased the level of DNA fragmentation induced by FasL-deficient DC, indicating the existence of additional potential (Fas-independent) pathways of DC- induced T cell death. These findings suggest that the costimulatory (B7- CD28) and T cell death-inducing pathways may play important counter- regulatory roles in dictating the outcome of (allogeneic) DC-T cell interactions.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
C. Chauvin and R. Josien
Dendritic Cells as Killers: Mechanistic Aspects and Potential Roles
J. Immunol., July 1, 2008; 181(1): 11 - 16.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Papewalis, B. Jacobs, M. Wuttke, E. Ullrich, T. Baehring, R. Fenk, H. S. Willenberg, S. Schinner, M. Cohnen, J. Seissler, et al.
IFN-{alpha} Skews Monocytes into CD56+-Expressing Dendritic Cells with Potent Functional Activities In Vitro and In Vivo
J. Immunol., February 1, 2008; 180(3): 1462 - 1470.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Guo, D. Weih, E. Meier, and F. Weih
Constitutive alternative NF-{kappa}B signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen
Blood, October 1, 2007; 110(7): 2381 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Harnaha, J. Machen, M. Wright, R. Lakomy, A. Styche, M. Trucco, S. Makaroun, and N. Giannoukakis
Interleukin-7 Is a Survival Factor for CD4+ CD25+ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells
Diabetes, January 1, 2006; 55(1): 158 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Huang, T. Tatsumi, E. Pizzoferrato, N. Vujanovic, and W. J. Storkus
Nitric Oxide Sensitizes Tumor Cells to Dendritic Cell-Mediated Apoptosis, Uptake, and Cross-Presentation
Cancer Res., September 15, 2005; 65(18): 8461 - 8470.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Machen, J. Harnaha, R. Lakomy, A. Styche, M. Trucco, and N. Giannoukakis
Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells
J. Immunol., October 1, 2004; 173(7): 4331 - 4341.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
R Okazaki, A Sakai, A Ootsuyama, T Sakata, T Nakamura, and T Norimura
Trabecular bone mass and bone formation are preserved after limb immobilisation in p53 null mice
Ann Rheum Dis, April 1, 2004; 63(4): 453 - 456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Colino and C. M. Snapper
Two Distinct Mechanisms For Induction of Dendritic Cell Apoptosis in Response to Intact Streptococcus pneumoniae
J. Immunol., September 1, 2003; 171(5): 2354 - 2365.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A H Lau, A de Creus, L Lu, and A W Thomson
Liver tolerance mediated by antigen presenting cells: fact or fiction?
Gut, August 1, 2003; 52(8): 1075 - 1078.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Ma, S. Qian, X. Liang, L. Wang, J. E. Woodward, N. Giannoukakis, P. D. Robbins, S. Bertera, M. Trucco, J. J. Fung, et al.
Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-{kappa}B Activity
Diabetes, August 1, 2003; 52(8): 1976 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. D. Elhalel, J.-H. Huang, W. Schmidt, J. Rachmilewitz, and M. L. Tykocinski
CTLA-4 {middle dot} FasL Induces Alloantigen-Specific Hyporesponsiveness
J. Immunol., June 15, 2003; 170(12): 5842 - 5850.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Maksimow, M. Santanen, S. Jalkanen, and A. Hanninen
Responding naive T cells differ in their sensitivity to Fas engagement: early death of many T cells is compensated by costimulation of surviving T cells
Blood, May 15, 2003; 101(10): 4022 - 4028.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
A H Lau and A W Thomson
Dendritic cells and immune regulation in the liver
Gut, February 1, 2003; 52(2): 307 - 314.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. A. Bonham, L. Peng, X. Liang, Z. Chen, L. Wang, L. Ma, H. Hackstein, P. D. Robbins, A. W. Thomson, J. J. Fung, et al.
Marked Prolongation of Cardiac Allograft Survival by Dendritic Cells Genetically Engineered with NF-{kappa}B Oligodeoxyribonucleotide Decoys and Adenoviral Vectors Encoding CTLA4-Ig
J. Immunol., September 15, 2002; 169(6): 3382 - 3391.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Lu, B. M. Janjic, J. Janjic, T. L. Whiteside, W. J. Storkus, and N. L. Vujanovic
Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. II. Role of TNF, Lymphotoxin-{alpha}1{beta}2, Fas Ligand, and TNF-Related Apoptosis-Inducing Ligand
J. Immunol., February 15, 2002; 168(4): 1831 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. F. Lipscomb and B. J. Masten
Dendritic Cells: Immune Regulators in Health and Disease
Physiol Rev, January 1, 2002; 82(1): 97 - 130.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. J. O'Connell, W. Li, Z. Wang, S. M. Specht, A. J. Logar, and A. W. Thomson
Immature and Mature CD8{alpha}+ Dendritic Cells Prolong the Survival of Vascularized Heart Allografts
J. Immunol., January 1, 2002; 168(1): 143 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Wei, K. Chen, G. C. Sharp, H. Yagita, and H. Braley-Mullen
Expression and Regulation of Fas and Fas Ligand on Thyrocytes and Infiltrating Cells During Induction and Resolution of Granulomatous Experimental Autoimmune Thyroiditis
J. Immunol., December 1, 2001; 167(11): 6678 - 6686.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Jodo, S. Xiao, A. Hohlbaum, D. Strehlow, A. Marshak-Rothstein, and S.-T. Ju
Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES
J. Biol. Chem., October 19, 2001; 276(43): 39938 - 39944.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Vanderheyde, E. Aksoy, Z. Amraoui, P. Vandenabeele, M. Goldman, and F. Willems
Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent Mechanism
J. Immunol., October 1, 2001; 167(7): 3565 - 3569.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P.-O. Vidalain, O. Azocar, H. Yagita, C. Rabourdin-Combe, and C. Servet-Delprat
Cytotoxic Activity of Human Dendritic Cells Is Differentially Regulated by Double-Stranded RNA and CD40 Ligand
J. Immunol., October 1, 2001; 167(7): 3765 - 3772.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Lu, A. Achour, M. Arlie, L. Cao, and J.-M. Andrieu
Enhanced Dendritic Cell-Driven Proliferation and Anti-HIV Activity of CD8+ T Cells by a New Phenothiazine Derivative, Aminoperazine
J. Immunol., September 1, 2001; 167(5): 2929 - 2935.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Kiba, S. Saito, K. Numata, Y. Kon, T. Mizutani, and H. Sekihara
Expression of apoptosis on rat liver by hepatic vagus hyperactivity after ventromedial hypothalamic lesioning
Am J Physiol Gastrointest Liver Physiol, May 1, 2001; 280(5): G958 - G967.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Li, L. Lu, Z. Wang, L. Wang, J. J. Fung, A. W. Thomson, and S. Qian
IL-12 Antagonism Enhances Apoptotic Death of T Cells Within Hepatic Allografts from Flt3 Ligand-Treated Donors and Promotes Graft Acceptance
J. Immunol., May 1, 2001; 166(9): 5619 - 5628.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J.-H. Huang and M. L. Tykocinski
CTLA-4-Fas ligand functions as a trans signal converter protein in bridging antigen-presenting cells and T cells
Int. Immunol., April 1, 2001; 13(4): 529 - 539.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
H.M. Pinedo, T.D. de Gruijl, E. van der Wall, and J. Buter
Biological Concepts of Prolonged Neoadjuvant Treatment plus GM-CSF in Locally Advanced Tumors
Oncologist, December 1, 2000; 5(6): 497 - 500.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
J. O. Funk, H. Walczak, C. Voigtlander, S. Berchtold, T. Baumeister, P. Rauch, S. Rossner, A. Steinkasserer, G. Schuler, and M. B. Lutz
Cutting Edge: Resistance to Apoptosis and Continuous Proliferation of Dendritic Cells Deficient for TNF Receptor-1
J. Immunol., November 1, 2000; 165(9): 4792 - 4796.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Trinite, C. Voisine, H. Yagita, and R. Josien
A Subset of Cytolytic Dendritic Cells in Rat
J. Immunol., October 15, 2000; 165(8): 4202 - 4208.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. E. Morelli, M. A. Antonysamy, T. Takayama, H. Hackstein, Z. Chen, S. Qian, N. B. Zurowski, and A. W. Thomson
Microchimerism, Donor Dendritic Cells, and Alloimmune Reactivity in Recipients of Flt3 Ligand-Mobilized Hemopoietic Cells: Modulation by Tacrolimus
J. Immunol., July 1, 2000; 165(1): 226 - 237.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. T. LEONARD, P. M. SOCCAL, L. SINGER, G. J. BERRY, J. THEODORE, P. G. HOLT, R. L. DOYLE, and G. D. ROSEN
Dendritic Cells and Macrophages in Lung Allografts . A Role in Chronic Rejection?
Am. J. Respir. Crit. Care Med., April 1, 2000; 161(4): 1349 - 1354.
[Abstract] [Full Text]

Home page
 BloodHome page
A. I. Chapoval, K. Tamada, and L. Chen
In vitro growth inhibition of a broad spectrum of tumor cell lines by activated human dendritic cells
Blood, April 1, 2000; 95(7): 2346 - 2351.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W.-P. Min, R. Gorczynski, X.-Y. Huang, M. Kushida, P. Kim, M. Obataki, J. Lei, R. M. Suri, and M. S. Cattral
Dendritic Cells Genetically Engineered to Express Fas Ligand Induce Donor-Specific Hyporesponsiveness and Prolong Allograft Survival
J. Immunol., January 1, 2000; 164(1): 161 - 167.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
N. A. Fanger, C. R. Maliszewski, K. Schooley, and T. S. Griffith
Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)
J. Exp. Med., October 18, 1999; 190(8): 1155 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Matsue, D. Edelbaum, A. C. Hartmann, A. Morita, P. R. Bergstresser, H. Yagita, K. Okumura, and A. Takashima
Dendritic Cells Undergo Rapid Apoptosis In Vitro During Antigen-Specific Interaction with CD4+ T Cells
J. Immunol., May 1, 1999; 162(9): 5287 - 5298.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Kanto, N. Hayashi, T. Takehara, T. Tatsumi, N. Kuzushita, A. Ito, Y. Sasaki, A. Kasahara, and M. Hori
Impaired Allostimulatory Capacity of Peripheral Blood Dendritic Cells Recovered from Hepatitis C Virus-Infected Individuals
J. Immunol., May 1, 1999; 162(9): 5584 - 5591.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-g. Zhang, X. Su, D. Liu, W. Liu, P. Yang, Z. Wang, C. K. Edwards, H. Bluethmann, J. D. Mountz, and T. Zhou
Induction of Specific T Cell Tolerance by Fas Ligand- Expressing Antigen-Presenting Cells
J. Immunol., February 1, 1999; 162(3): 1423 - 1430.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. A. ROSSINI, D. L. GREINER, and J. P. MORDES
Induction of Immunologic Tolerance for Transplantation
Physiol Rev, January 1, 1999; 79(1): 99 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. Dai, B. T. Konieczny, F. K. Baddoura, and F. G. Lakkis
Impaired Alloantigen-Mediated T Cell Apoptosis and Failure To Induce Long-Term Allograft Survival in IL-2-Deficient Mice
J. Immunol., August 15, 1998; 161(4): 1659 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Gardby, P. Lane, and N. Y. Lycke
Requirements for B7-CD28 Costimulation in Mucosal IgA Responses: Paradoxes Observed in CTLA4-H{gamma}1 Transgenic Mice
J. Immunol., July 1, 1998; 161(1): 49 - 59.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Antonysamy, R. J. Steptoe, A. Khanna, W. A. Rudert, V. M. Subbotin, and A. W. Thomson
Flt-3 Ligand Increases Microchimerism But Can Prevent the Therapeutic Effect of Donor Bone Marrow in Transiently Immunosuppressed Cardiac Allograft Recipients
J. Immunol., April 15, 1998; 160(8): 4106 - 4113.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. D. McLeod, L. S. K. Walker, Y. I. Patel, G. Boulougouris, and D. M. Sansom
Activation of Human T Cells with Superantigen (Staphylococcal Enterotoxin B) and CD28 Confers Resistance to Apoptosis via CD95
J. Immunol., March 1, 1998; 160(5): 2072 - 2079.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Shortman and C. Caux
Dendritic Cell Development: Multiple Pathways to Nature's Adjuvants
Stem Cells, November 1, 1997; 15(6): 409 - 419.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1997 by The American Association of Immunologists, Inc. All rights reserved.