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The Journal of Immunology, Vol 158, Issue 11 5349-5356, Copyright © 1997 by American Association of Immunologists

ARTICLES

Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice

L Romani, A Mencacci, E Cenci, R Spaccapelo, G Del Sero, I Nicoletti, G Trinchieri, F Bistoni and P Puccetti
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy.

Neutrophil defects predispose to severe fungal infections, yet the immunomodulatory role of these cells is poorly defined. The contribution of neutrophils to the early cytokine balance governing Th1 and Th2 cell development was examined in mice with candidiasis. Neutrophils secreted IL-12 and IL-10, correlating with the respective development of self-limiting (Th1-associated) and progressive (Th2- associated) disease. Exogenous IL-12 was effective in protecting neutropenic hosts susceptible to infection. These results suggest that 1) neutrophils, via their ability to release cytokines, play an active role in determining the qualitative development of the T cell response, and 2) their early role in anticandidal immunity can be replaced by exogenous IL-12.


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