| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Journal of Immunology, Vol 158, Issue 11 5283-5291, Copyright © 1997 by American Association of Immunologists
ARTICLES |
K Ando, K Hiroishi, T Kaneko, T Moriyama, Y Muto, N Kayagaki, H Yagita, K Okumura and M Imawari
Hepatology Division, Jichi Medical School, Kawachi-gun, Tochigi, Japan.
In chronic hepatitis C, Fas expression is up-regulated in the hepatocytes, especially near liver-infiltrating lymphocytes, and Fas ligand is expressed on the lymphocytes. The presence of hepatitis C virus (HCV)-specific CTLs has been demonstrated both in peripheral blood and among liver-infiltrating lymphocytes of patients with chronic hepatitis C. We studied the killing mechanisms of HCV-specific human CTLs using target cells that were sensitive or resistant to agonistic anti-Fas Abs and TNF-alpha. We show that HCV-specific CTL clones kill non-Ag-bearing bystander cells as well as Ag-bearing cells, although the bystander killing is less efficient than the specific target cell killing, and the efficacy of the bystander killing of anti-Fas- and soluble TNF-alpha-sensitive cells is greater than that of resistant cells. We also show that the killing of Ag-presenting, sensitive cells is mediated by Fas ligand and TNF-alpha as well as perforin, although the latter plays a major role in the killing at a low E:T ratio, and that the killing of sensitive bystander cells is primarily mediated by Fas ligand and TNF-alpha on CTLs expressed upon specific Ag stimulation, which may be relevant to the bystander lysis by HCV- specific CTLs of uninfected hepatocytes, in which Fas expression is up- regulated. Activated CTLs also kill bystander cells by the perforin- based mechanism, although it requires a high E:T ratio. The effective bystander killing requires a close intercellular contact between CTLs and target cells, although TNF-alpha released from the CTLs mediates lysis of the bystander cells without a close cell-cell contact.
This article has been cited by other articles:
|
|
 |
|
  K. A. Andrew, H. M. A. Simkins, S. Witzel, R. Perret, J. Hudson, I. F. Hermans, D. S. Ritchie, J. Yang, and F. Ronchese Dendritic Cells Treated with Lipopolysaccharide Up-Regulate Serine Protease Inhibitor 6 and Remain Sensitive to Killing by Cytotoxic T Lymphocytes In Vivo J. Immunol., December 15, 2008; 181(12): 8356 - 8362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ito, K. Ando, T. Ishikawa, T. Nakayama, M. Taniguchi, K. Saito, M. Imawari, H. Moriwaki, T. Yokochi, S. Kakumu, et al. Role of V{alpha}14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of V{alpha}14+ NKT cells promotes the breakage of CTL tolerance Int. Immunol., July 1, 2008; 20(7): 869 - 879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Polakos, I. Klein, M. V. Richter, D. M. Zaiss, M. Giannandrea, I. N. Crispe, and D. J. Topham Early Intrahepatic Accumulation of CD8+ T Cells Provides a Source of Effectors for Nonhepatic Immune Responses J. Immunol., July 1, 2007; 179(1): 201 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Liang, Y. Liu, Q. Zhang, L. Gao, L. Han, C. Ma, L. Zhang, Y. H. Chen, and W. Sun Hepatitis B Virus Sensitizes Hepatocytes to TRAIL-Induced Apoptosis through Bax J. Immunol., January 1, 2007; 178(1): 503 - 510. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Nachbur, D. Kassahn, S. Yousefi, D. F. Legler, and T. Brunner Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts Blood, April 1, 2006; 107(7): 2790 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tsunoda, L.-Q. Kuang, M. Kobayashi-Warren, and R. S. Fujinami Central Nervous System Pathology Caused by Autoreactive CD8+ T-Cell Clones following Virus Infection J. Virol., December 1, 2005; 79(23): 14640 - 14646. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. Cruise, H. M. Melief, J. Lukens, C. Soguero, and Y. S. Hahn Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation J. Leukoc. Biol., August 1, 2005; 78(2): 412 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Yeo, Y.-G. Yoo, H.-S. Choi, Y. K. Pak, and M.-O. Lee Negative Cross-Talk between Nur77 and Small Heterodimer Partner and Its Role in Apoptotic Cell Death of Hepatoma Cells Mol. Endocrinol., April 1, 2005; 19(4): 950 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ahmad and F. Alvarez Role of NK and NKT cells in the immunopathogenesis of HCV-induced hepatitis J. Leukoc. Biol., October 1, 2004; 76(4): 743 - 759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gremion, B. Grabscheid, B. Wolk, D. Moradpour, J. Reichen, W. Pichler, and A. Cerny Cytotoxic T Lymphocytes Derived from Patients with Chronic Hepatitis C Virus Infection Kill Bystander Cells via Fas-FasL Interaction J. Virol., February 15, 2004; 78(4): 2152 - 2157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nikiforow, K. Bottomly, G. Miller, and C. Munz Cytolytic CD4+-T-Cell Clones Reactive to EBNA1 Inhibit Epstein-Barr Virus-Induced B-Cell Proliferation J. Virol., November 15, 2003; 77(22): 12088 - 12104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kasahara, K. Ando, K. Saito, K. Sekikawa, H. Ito, T. Ishikawa, H. Ohnishi, M. Seishima, S. Kakumu, and H. Moriwaki Lack of Tumor Necrosis Factor Alpha Induces Impaired Proliferation of Hepatitis B Virus-Specific Cytotoxic T Lymphocytes J. Virol., February 15, 2003; 77(4): 2469 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Musey, Y. Ding, J. Cao, J. Lee, C. Galloway, A. Yuen, K. R. Jerome, and M. J. McElrath Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes J. Virol., December 16, 2002; 77(1): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Tsunoda, L.-Q. Kuang, and R. S. Fujinami Induction of Autoreactive CD8+ Cytotoxic T Cells during Theiler's Murine Encephalomyelitis Virus Infection: Implications for Autoimmunity J. Virol., November 13, 2002; 76(24): 12834 - 12844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Le Roy, M. Baron, W. Faigle, D. Clement, D. M. Lewinsohn, D. N. Streblow, J. A. Nelson, S. Amigorena, and J.-L. Davignon Infection of APC by Human Cytomegalovirus Controlled Through Recognition of Endogenous Nuclear Immediate Early Protein 1 by Specific CD4+ T Lymphocytes J. Immunol., August 1, 2002; 169(3): 1293 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Dorothee, I. Vergnon, J. Menez, H. Echchakir, D. Grunenwald, M. Kubin, S. Chouaib, and F. Mami-Chouaib Tumor-Infiltrating CD4+ T Lymphocytes Express APO2 Ligand (APO2L)/TRAIL upon Specific Stimulation with Autologous Lung Carcinoma Cells: Role of IFN-{alpha} on APO2L/TRAIL Expression and -Mediated Cytotoxicity J. Immunol., July 15, 2002; 169(2): 809 - 817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Sun, R. L. Burton, and K. G. Lucas Cytokine production and cytolytic mechanism of CD4+ cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus-specific T-cell cultures Blood, May 1, 2002; 99(9): 3302 - 3309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Cao, P. Meuleman, I. Desombere, M. Sallberg, and G. Leroux-Roels In Vivo Inhibition of Anti-Hepatitis B Virus Core Antigen (HBcAg) Immunoglobulin G Production by HBcAg-Specific CD4+ Th1-Type T-Cell Clones in a hu-PBL-NOD/SCID Mouse Model J. Virol., December 1, 2001; 75(23): 11449 - 11456. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Kato, M. Kobune, T. Nakamura, G. Kuroiwa, K. Takada, R. Takimoto, Y. Sato, K. Fujikawa, M. Takahashi, T. Takayama, et al. Normalization of Elevated Hepatic 8-Hydroxy-2'-Deoxyguanosine Levels in Chronic Hepatitis C Patients by Phlebotomy and Low Iron Diet Cancer Res., December 1, 2001; 61(24): 8697 - 8702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Berson, V. Descatoire, A. Sutton, D. Fau, B. Maulny, N. Vadrot, G. Feldmann, B. Berthon, T. Tordjmann, and D. Pessayre Toxicity of Alpidem, a Peripheral Benzodiazepine Receptor Ligand, but Not Zolpidem, in Rat Hepatocytes: Role of Mitochondrial Permeability Transition and Metabolic Activation J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 793 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Musallam, C. Ethier, P. S. Haddad, and M. Bilodeau Role of EGF receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1360 - G1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Gorham, J. T. Lin, J. L. Sung, L. A. Rudner, and M. A. French Genetic Regulation of Autoimmune Disease: BALB/c Background TGF-{{beta}}1-Deficient Mice Develop Necroinflammatory IFN-{{gamma}}-Dependent Hepatitis J. Immunol., May 15, 2001; 166(10): 6413 - 6422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. He, Y. Noda, and K. Sugiyama Green Tea Suppresses Lipopolysaccharide-Induced Liver Injury in D-Galactosamine-Sensitized Rats J. Nutr., May 1, 2001; 131(5): 1560 - 1567. [Abstract] [Full Text]
|
|
|
|
|
|
M. Nieda, A. Nicol, Y. Koezuka, A. Kikuchi, N. Lapteva, Y. Tanaka, K. Tokunaga, K. Suzuki, N. Kayagaki, H. Yagita, et al. TRAIL expression by activated human CD4+V{alpha}24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells Blood, April 1, 2001; 97(7): 2067 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hayashida, H. Kawano, T. Nakano, K. Shiraki, and A. Suzuki Cell Death Induction by CTL: Perforin/Granzyme B System Dominantly Acts for Cell Death Induction in Human Hepatocellular Carcinoma Cells Experimental Biology and Medicine, November 1, 2000; 225(2): 143 - 150. [Abstract] [Full Text]
|
|
|
|
 |
|
 Y. Wang, B. Detrick, Z.-X. Yu, J. Zhang, L. Chesky, and J. J. Hooks The Role of Apoptosis within the Retina of Coronavirus-Infected Mice Invest. Ophthalmol. Vis. Sci., September 1, 2000; 41(10): 3011 - 3018. [Abstract] [Full Text]
|
|
|
|
|
|
K. Tsubota, H. Fujita, K. Tsuzaka, and T. Takeuchi Mikulicz's Disease and Sjogren's Syndrome Invest. Ophthalmol. Vis. Sci., June 1, 2000; 41(7): 1666 - 1673. [Abstract] [Full Text]
|
|
|
|
|
|
V. Loyer, P. Fontaine, S. Pion, F. Hetu, D.-C. Roy, and C. Perreault The In Vivo Fate of APCs Displaying Minor H Antigen and/or MHC Differences Is Regulated by CTLs Specific for Immunodominant Class I-Associated Epitopes J. Immunol., December 15, 1999; 163(12): 6462 - 6467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Shankar, Z. Xu, and J. Lieberman Viral-Specific Cytotoxic T Lymphocytes Lyse Human Immunodeficiency Virus-Infected Primary T Lymphocytes by the Granule Exocytosis Pathway Blood, November 1, 1999; 94(9): 3084 - 3093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kayagaki, N. Yamaguchi, M. Nakayama, K. Takeda, H. Akiba, H. Tsutsui, H. Okamura, K. Nakanishi, K. Okumura, and H. Yagita Expression and Function of TNF-Related Apoptosis-Inducing Ligand on Murine Activated NK Cells J. Immunol., August 15, 1999; 163(4): 1906 - 1913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fujihara, H. Fujita, K. Tsubota, K. Saito, K. Tsuzaka, T. Abe, and T. Takeuchi Preferential Localization of CD8+ {alpha}E{beta}7+ T Cells Around Acinar Epithelial Cells with Apoptosis in Patients with Sjogren's Syndrome J. Immunol., August 15, 1999; 163(4): 2226 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. L. Jones, A. S. Day, H. A. Jennings, and P. M. Sherman Helicobacter pylori Induces Gastric Epithelial Cell Apoptosis in Association with Increased Fas Receptor Expression Infect. Immun., August 1, 1999; 67(8): 4237 - 4242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Brochu, B. Rioux-Masse, J. Roy, D.-C. Roy, and C. Perreault Massive Activation-Induced Cell Death of Alloreactive T Cells With Apoptosis of Bystander Postthymic T Cells Prevents Immune Reconstitution in Mice With Graft-Versus-Host Disease Blood, July 15, 1999; 94(2): 390 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yasukawa, H. Ohminami, Y. Yakushijin, J. Arai, A. Hasegawa, Y. Ishida, and S. Fujita Fas-Independent Cytotoxicity Mediated by Human CD4+ CTL Directed Against Herpes Simplex Virus-Infected Cells J. Immunol., May 15, 1999; 162(10): 6100 - 6106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Gagnon, F. A. Ennis, and A. L. Rothman Bystander Target Cell Lysis and Cytokine Production by Dengue Virus-Specific Human CD4+ Cytotoxic T-Lymphocyte Clones J. Virol., May 1, 1999; 73(5): 3623 - 3629. [Abstract] [Full Text]
|
|
|
|
|
|
T. Matsushita, K. Ando, K. Kimura, H. Ohnishi, M. Imawari, Y. Muto, and H. Moriwaki IL-12 induces specific cytotoxicity against regenerating hepatocytes in vivo Int. Immunol., May 1, 1999; 11(5): 657 - 665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Perry, K. Feilzer, S. Hughes, and H. D. Caldwell Clearance of Chlamydia trachomatis from the Murine Genital Mucosa Does Not Require Perforin-Mediated Cytolysis or Fas-Mediated Apoptosis Infect. Immun., March 1, 1999; 67(3): 1379 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kayagaki, N. Yamaguchi, M. Nakayama, A. Kawasaki, H. Akiba, K. Okumura, and H. Yagita Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity J. Immunol., March 1, 1999; 162(5): 2639 - 2647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ohminami, M. Yasukawa, S. Kaneko, Y. Yakushijin, Y. Abe, Y. Kasahara, Y. Ishida, and S. Fujita Fas-Independent and Nonapoptotic Cytotoxicity Mediated by a Human CD4+ T-Cell Clone Directed Against an Acute Myelogenous Leukemia-Associated DEK-CAN Fusion Peptide Blood, February 1, 1999; 93(3): 925 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Johnstone, E. Cretney, and M. J. Smyth P-Glycoprotein Protects Leukemia Cells Against Caspase-Dependent, but not Caspase-Independent, Cell Death Blood, February 1, 1999; 93(3): 1075 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Sayers, A. D. Brooks, J.-K. Lee, R. G. Fenton, K. L. Komschlies, J. M. Wigginton, R. Winkler-Pickett, and R. H. Wiltrout Molecular Mechanisms of Immune-Mediated Lysis of Murine Renal Cancer: Differential Contributions of Perforin-Dependent Versus Fas-Mediated Pathways in Lysis by NK and T Cells J. Immunol., October 15, 1998; 161(8): 3957 - 3965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Jensen, A. A. Glass, W. R. Clark, E. J. Wing, J. F. Miller, and S. H. Gregory Fas (CD95)-Dependent Cell-Mediated Immunity to Listeria monocytogenes Infect. Immun., September 1, 1998; 66(9): 4143 - 4150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Smyth, E. Krasovskis, and R. W. Johnstone Fas Ligand-Mediated Lysis of Self Bystander Targets by Human Papillomavirus-Specific CD8+ Cytotoxic T Lymphocytes J. Virol., July 1, 1998; 72(7): 5948 - 5954. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kawano, J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, H. Sato, E. Kondo, M. Harada, H. Koseki, T. Nakayama, et al. Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha 14 NKT cells PNAS, May 12, 1998; 95(10): 5690 - 5693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Smyth and J. A. Trapani The Relative Role of Lymphocyte Granule Exocytosis versus Death Receptor-Mediated Cytotoxicity in Viral Pathophysiology J. Virol., January 1, 1998; 72(1): 1 - 9. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cui, T. Shin, T. Kawano, H. Sato, E. Kondo, I. Toura, Y. Kaneko, H. Koseki, M. Kanno, and M. Taniguchi Requirement for V  14 NKT Cells in IL-12-Mediated Rejection of TumorsScience, November 28, 1997; 278(5343): 1623 - 1626. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. H. Nietsch, M. W. Roe, J. F. Fiekers, A. L. Moore, and S. D. Lidofsky Activation of Potassium and Chloride Channels by Tumor Necrosis Factor alpha . ROLE IN LIVER CELL DEATH J. Biol. Chem., June 30, 2000; 275(27): 20556 - 20561. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
