| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 158, Issue 1 5-8, Copyright © 1997 by American Association of Immunologists
CUTTING EDGE |
JW Maciaszek, NA Parada, WW Cruikshank, DM Center, H Kornfeld and GA Viglianti
The Program in Virology and Immunology, University of Massachusetts Medical Center, Worcester 01605, USA.
IL-16 is produced by CD8+ lymphocytes and has been reported to inhibit HIV-1 and SIV replication in infected PBMCs. CD4 serves as a receptor for the secreted form of IL-16, and IL-16 binding to CD4 induces signal transduction, which affects the activation state of the cell. We hypothesized, therefore, that the effect of IL-16 on HIV-1 replication might occur at the level of virus expression. In transient transfection studies with HIV-1 LTR-reporter gene constructs we found that pretreatment of CD4+ lymphoid cells with recombinant IL-16 repressed HIV-1 promoter activity up to 60-fold, preventing both PMA and Tat activation. This effect of IL-16 required sequences contained within the core enhancer, but was not simply due to the down-regulation of transcription factors binding to this element.
This article has been cited by other articles:
|
|
 |
|
  M. D. Mannie and D. J. Abbott A Fusion Protein Consisting of IL-16 and the Encephalitogenic Peptide of Myelin Basic Protein Constitutes an Antigen-Specific Tolerogenic Vaccine That Inhibits Experimental Autoimmune Encephalomyelitis J. Immunol., August 1, 2007; 179(3): 1458 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Qi, J. Wang, S. Mandadi, K. Tanaka, B. D. Roufogalis, M. C. Madigan, K. Lai, F. Yan, B. H. Chong, R. L. Stevens, et al. Human and mouse mast cells use the tetraspanin CD9 as an alternate interleukin-16 receptor Blood, January 1, 2006; 107(1): 135 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Archin, L. van den Boom, L. Perelygina, J. M. Hilliard, and S. S. Atherton Delayed Spread and Reduction in Virus Titer after Anterior Chamber Inoculation of a Recombinant of HSV-1 Expressing IL-16 Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 3066 - 3076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Qi, R. L. Stevens, R. Wadley, A. Collins, M. Cooley, H. M. Naif, N. Nasr, A. Cunningham, G. Katsoulotos, Y. Wanigasek, et al. IL-16 Regulation of Human Mast Cells/Basophils and Their Susceptibility to HIV-1 J. Immunol., April 15, 2002; 168(8): 4127 - 4134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Cristillo and B. E. Bierer Identification of Novel Targets of Immunosuppressive Agents by cDNA-based Microarray Analysis J. Biol. Chem., February 1, 2002; 277(6): 4465 - 4476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Majka, A. Janowska-Wieczorek, J. Ratajczak, K. Ehrenman, Z. Pietrzkowski, M. A. Kowalska, A. M. Gewirtz, S. G. Emerson, and M. Z. Ratajczak Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner Blood, May 15, 2001; 97(10): 3075 - 3085. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. A. Darcissac, M.-J. Truong, J. Dewulf, Y. Mouton, A. Capron, and G. M. Bahr The Synthetic Immunomodulator Murabutide Controls Human Immunodeficiency Virus Type 1 Replication at Multiple Levels in Macrophages and Dendritic Cells J. Virol., September 1, 2000; 74(17): 7794 - 7802. [Abstract] [Full Text]
|
|
|
|
|
|
T. Yoshimoto, C.-R. Wang, T. Yoneto, A. Matsuzawa, W. W. Cruikshank, and H. Nariuchi Role of IL-16 in delayed-type hypersensitivity reaction Blood, May 1, 2000; 95(9): 2869 - 2874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I Sekigawa, S Lee, H Kaneko, N Iida, H Hashimoto, S Hirose, and Y Kaneko The possible role of interleukin-16 in the low incidence of HIV infection in patients with systemic lupus erythematosus Lupus, February 1, 2000; 9(2): 155 - 156. [PDF]
|
|
|
|
 |
|
 H. KOZIEL, S. KIM, C. REARDON, X. LI, R. GARLAND, P. PINKSTON, and H. KORNFELD Enhanced In Vivo Human Immunodeficiency Virus-1 Replication in the Lungs of Human Immunodeficiency Virus-Infected Persons with Pneumocystis carinii Pneumonia Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2048 - 2055. [Abstract] [Full Text]
|
|
|
|
|
|
J. Nicoll, W. W. Cruikshank, W. Brazer, Y. Liu, D. M. Center, and H. Kornfeld Identification of Domains in IL-16 Critical for Biological Activity J. Immunol., August 15, 1999; 163(4): 1827 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Truong, E. C. A. Darcissac, E. Hermann, J. Dewulf, A. Capron, and G. M. Bahr Interleukin-16 Inhibits Human Immunodeficiency Virus Type 1 Entry and Replication in Macrophages and in Dendritic Cells J. Virol., August 1, 1999; 73(8): 7008 - 7013. [Abstract] [Full Text]
|
|
|
|
|
|
P. Zhou, K. Devadas, D. Tewari, A. Jegorow, and A. L. Notkins Processing, Secretion, and Anti-HIV-1 Activity of IL-16 With or Without a Signal Peptide in CD4+ T Cells J. Immunol., July 15, 1999; 163(2): 906 - 912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. K. Sharma, J. Trujillo, H.-F. Song, F. P. Saitta, O. B. Laeyendecker, R. Castillo, S. Arango-Jaramillo, G. Sridharan, M. Dettenhofer, K. Blakemore, et al. A Novel Factor Produced by Placental Cells with Activity Against HIV-1 J. Immunol., December 1, 1998; 161(11): 6406 - 6412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. L. Chupp, E. A. Wright, D. Wu, M. Vallen-Mashikian, W. W. Cruikshank, D. M. Center, H. Kornfeld, and J. S. Berman Tissue and T Cell Distribution of Precursor and Mature IL-16 J. Immunol., September 15, 1998; 161(6): 3114 - 3119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Van Baalen, M. Schutten, R. C. Huisman, P. H. M. Boers, R. A. Gruters, and A. D. M. E. Osterhaus Kinetics of Antiviral Activity by Human Immunodeficiency Virus Type 1-Specific Cytotoxic T Lymphocytes (CTL) and Rapid Selection of CTL Escape Virus In Vitro J. Virol., August 1, 1998; 72(8): 6851 - 6857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Keane, J. Nicoll, S. Kim, D. M. H. Wu, W. W. Cruikshank, W. Brazer, B. Natke, Y. Zhang, D. M. Center, and H. Kornfeld Conservation of Structure and Function Between Human and Murine IL-16 J. Immunol., June 15, 1998; 160(12): 5945 - 5954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, H. Kornfeld, W. W. Cruikshank, S. Kim, C. C. Reardon, and D. M. Center Nuclear Translocation of the N-terminal Prodomain of Interleukin-16 J. Biol. Chem., January 5, 2001; 276(2): 1299 - 1303. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
