| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 9 3886-3892, Copyright © 1996 by American Association of Immunologists
ARTICLES |
M Satoh, S Seki, W Hashimoto, K Ogasawara, T Kobayashi, K Kumagai, S Matsuno and K Takeda
First Department of Surgery, Tohoku University School of Medicine, Sendai, Japan.
Populations of cytotoxic CD3+CD56+ cells were selectively expanded when monocyte-depleted human PBL (M(-) PBL) were cultured with 20 U/ml IL-12 and 100 U/ml IL-2. In a majority of cases, CD4-CD8- as well as CD8+ gammadelta T cells with CD56 Ag were induced, but in some cases CD4+CD56+ alphabeta T cells were selectively increased. Determination of which will increase, gammadelta or alphabeta T cells, apparently is dependent upon individuals. When M(-) PBL were stimulated with IL-12 and IL-2 in the presence of immobilized anti-CD3 Ab, CD8+CD56+ alphabeta T cells increased exclusively. When M(-) PBL were cultured by IL-2 alone, CD3+CD56- cell expansion was predominant while CD3+CD56+ cells remained a minor population. Cytotoxic activity of M(-) PBL cultured with a combination of IL-12 and IL-2 is much greater than when cultured with IL-2 alone. The cytotoxicity of activated M(-) PBL was abrogated by the depletion of either CD3+ or CD56+ cells irrespective of their gammadelta or alphabeta phenotypes. These types of cells are preferentially present in the livers of humans. The results revealed that, under certain conditions, IL-12 synergizes with IL-2 to induce potent cytotoxic T cells with CD56 Ag of humans, and suggest that these cells in the human liver are functionally similar to NK1+ alphabeta T cells in murine liver.
This article has been cited by other articles:
|
|
 |
|
  A. A.Z. Alexander, A. Maniar, J.-S. Cummings, A. M. Hebbeler, D. H. Schulze, B. R. Gastman, C. D. Pauza, S. E. Strome, and A. I. Chapoval Isopentenyl Pyrophosphate-Activated CD56+ {gamma}{delta} T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma Clin. Cancer Res., July 1, 2008; 14(13): 4232 - 4240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Guia, C. Cognet, L. de Beaucoudrey, M. S. Tessmer, E. Jouanguy, C. Berger, O. Filipe-Santos, J. Feinberg, Y. Camcioglu, J. Levy, et al. A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo Blood, May 15, 2008; 111(10): 5008 - 5016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Korosec, K. Osolnik, I. Kern, M. Silar, K. Mohorcic, and M. Kosnik Expansion of Pulmonary CD8+CD56+ Natural Killer T-Cells in Hypersensitivity Pneumonitis Chest, October 1, 2007; 132(4): 1291 - 1297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Motegi, M. Kinoshita, K. Sato, N. Shinomiya, S. Ono, S. Nonoyama, H. Hiraide, and S. Seki An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells J. Leukoc. Biol., March 1, 2006; 79(3): 463 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Atanackovic, K. Pollok, C. Faltz, I. Boeters, R. Jung, A. Nierhaus, K.-M. Braumann, D. K. Hossfeld, and S. Hegewisch-Becker Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R585 - R594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Ahn, H. Chung, D.-s. Lee, Y. S. Yu, and H. G. Yu CD8brightCD56+ T Cells Are Cytotoxic Effectors in Patients with Active Behcet's Uveitis J. Immunol., November 1, 2005; 175(9): 6133 - 6142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Ahn, J.-M. Seo, J. Yu, F. S. Oh, H. Chung, and H. G. Yu Down-Regulation of IFN-{gamma}-Producing CD56+ T Cells after Combined Low-Dose Cyclosporine/Prednisone Treatment in Patients with Behcet's Uveitis Invest. Ophthalmol. Vis. Sci., July 1, 2005; 46(7): 2458 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Dyugovskaya, P. Lavie, M. Hirsh, and L. Lavie Activated CD8+ T-lymphocytes in obstructive sleep apnoea Eur. Respir. J., May 1, 2005; 25(5): 820 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Atanackovic, A. Block, A. de Weerth, C. Faltz, D. K. Hossfeld, and S. Hegewisch-Becker Characterization of Effusion-Infiltrating T Cells: Benign versus Malignant Effusions Clin. Cancer Res., April 15, 2004; 10(8): 2600 - 2608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Wajchman, C. W. Pierce, V. A. Varma, M. M. Issa, J. Petros, and K. E. Dombrowski Ex Vivo Expansion of CD8+CD56+ and CD8+CD56- Natural Killer T Cells Specific for MUC1 Mucin Cancer Res., February 1, 2004; 64(3): 1171 - 1180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Kamath, L. Wang, H. Das, L. Li, V. N. Reinhold, and J. F. Bukowski Antigens in tea-beverage prime human Vgamma 2Vdelta 2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses PNAS, May 13, 2003; 100(10): 6009 - 6014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. De Creus, K. Van Beneden, F. Stevenaert, V. Debacker, J. Plum, and G. Leclercq Developmental and Functional Defects of Thymic and Epidermal V{gamma}3 Cells in IL-15-Deficient and IFN Regulatory Factor-1-Deficient Mice J. Immunol., June 15, 2002; 168(12): 6486 - 6493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yanagisawa, K.-i. Seino, Y. Ishikawa, M. Nozue, T. Todoroki, and K. Fukao Impaired Proliferative Response of V{alpha}24 NKT Cells from Cancer Patients Against {alpha}-Galactosylceramide J. Immunol., June 15, 2002; 168(12): 6494 - 6499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Dunne, S. Lynch, C. O'Farrelly, S. Todryk, J. E. Hegarty, C. Feighery, and D. G. Doherty Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15 J. Immunol., September 15, 2001; 167(6): 3129 - 3138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Lundberg and G. A. Splitter gamma delta + T-Lymphocyte Cytotoxicity against Envelope-Expressing Target Cells Is Unique to the Alymphocytic State of Bovine Leukemia Virus Infection in the Natural Host J. Virol., September 15, 2000; 74(18): 8299 - 8306. [Abstract] [Full Text]
|
|
|
|
|
|
M. R. Goodier and M. Londei Lipopolysaccharide Stimulates the Proliferation of Human CD56+CD3- NK Cells: A Regulatory Role of Monocytes and IL-10 J. Immunol., July 1, 2000; 165(1): 139 - 147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yato and Y. Matsumoto CD56+ T cells in the peripheral blood of uveitis patients Br. J. Ophthalmol., December 1, 1999; 83(12): 1386 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. Doherty, S. Norris, L. Madrigal-Estebas, G. McEntee, O. Traynor, J. E. Hegarty, and C. O'Farrelly The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns J. Immunol., August 15, 1999; 163(4): 2314 - 2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tuo, F. W. Bazer, W. C. Davis, D. Zhu, and W. C. Brown Differential Effects of Type I IFNs on the Growth of WC1- CD8+ {gamma}{delta} T Cells and WC1+ CD8- {gamma}{delta} T Cells In Vitro J. Immunol., January 1, 1999; 162(1): 245 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Seki, S.-i. Osada, S. Ono, S. Aosasa, Y. Habu, T. Nishikage, H. Mochizuki, and H. Hiraide Role of Liver NK Cells and Peritoneal Macrophages in Gamma Interferon and Interleukin-10 Production in Experimental Bacterial Peritonitis in Mice Infect. Immun., November 1, 1998; 66(11): 5286 - 5294. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Okura, K. Takeda, S. Honda, H. Hanawa, H. Watanabe, M. Kodama, T. Izumi, Y. Aizawa, S. Seki, and T. Abo Recombinant Murine Interleukin-12 Facilitates Induction of Cardiac Myosin–Specific Type 1 Helper T Cells in Rats Circ. Res., June 1, 1998; 82(10): 1035 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. E. Garcia, D. Jullien, M. Song, K. Uyemura, K. Shuai, C. T. Morita, and R. L. Modlin IL-15 Enhances the Response of Human {gamma}{delta} T Cells to Nonpetide Microbial Antigens J. Immunol., May 1, 1998; 160(9): 4322 - 4329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ogasawara, K. Takeda, W. Hashimoto, M. Satoh, R. Okuyama, N. Yanai, M. Obinata, K. Kumagai, H. Takada, H. Hiraide, et al. Involvement of NK1+ T Cells and Their IFN-{gamma} Production in the Generalized Shwartzman Reaction J. Immunol., April 1, 1998; 160(7): 3522 - 3527. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
