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The Journal of Immunology, Vol 157, Issue 9 3791-3795, Copyright © 1996 by American Association of Immunologists

ARTICLES

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways

GO Cory, L MacCarthy-Morrogh, S Banin, I Gout, PM Brickell, RJ Levinsky, C Kinnon and RC Lovering
Institute of Child Health, University of London, United Kingdom.

Wiskott-Aldrich syndrome is an X-linked combined immunodeficiency affecting cells of several different hemopoietic lineages. The Wiskott- Aldrich syndrome protein (WASP), which has no homology with any other known protein families, is rich in proline motifs known to contribute to Src homology 3 binding sites. However, its function has not been determined. The Tec family of cytoplasmic tyrosine kinases, which include Btk (the X-linked agammaglobulinemia gene), Itk, and Tec, is thought to be involved in lymphoid cell signaling pathways. In this work, we show binding of WASP to the Src homology 3 domains of Btk, Itk, Tec, Grb2, and phospholipase C-gamma, which suggests a function for WASP in lymphoid cell signaling.


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