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The Journal of Immunology, Vol 157, Issue 7 2745-2748, Copyright © 1996 by American Association of Immunologists
CUTTING EDGE |
RA Seder, BL Kelsall and D Jankovic
Laboratory of Clinical Investigation, National Institutes of Health, Bethesda, MD 20892, USA. rseder@nih.gov
IL-12 has been shown to be important in the generation of a functional Th1 response in animal models of both infectious and autoimmune disease. Furthermore, the role of IL-12 in the maintenance of the immune responses in these diseases is now emerging. Herein, we discuss the idea that memory responses for certain infections may be IL-12 independent, whereas memory responses for specific autoimmune diseases still require IL-12 to maintain a pathogenic response.
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