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The Journal of Immunology, Vol 157, Issue 6 2234-2238, Copyright © 1996 by American Association of Immunologists
CUTTING EDGE |
GW Chacko, S Tridandapani, JE Damen, L Liu, G Krystal and KM Coggeshall
Department of Microbiology, Ohio State University, Columbus 43210, USA.
Stimulation of the B cell Ag receptor (BCR) has been reported to induce tyrosine phosphorylation of a 145-kDa protein and its association with the adapter protein Shc. We have identified this protein as the novel inositol polyphosphate 5-phosphatase (SHIP). Further analysis revealed that both maximal phosphorylation of SHIP and its association with Shc require co-clustering with the Fc receptor for IgG (Fc gamma RII) rather than stimulation of the BCR alone. Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism.
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S. L. Harmer and A. L. DeFranco The Src Homology Domain 2-Containing Inositol Phosphatase SHIP Forms a Ternary Complex with Shc and Grb2 in Antigen Receptor-stimulated B Lymphocytes J. Biol. Chem., April 23, 1999; 274(17): 12183 - 12191. [Abstract] [Full Text] [PDF]
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D. M. Lucas and L. R. Rohrschneider A Novel Spliced Form of SH2-Containing Inositol Phosphatase Is Expressed During Myeloid Development Blood, March 15, 1999; 93(6): 1922 - 1933. [Abstract] [Full Text] [PDF]
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N. Gupta, A. M. Scharenberg, D. A. Fruman, L. C. Cantley, J.-P. Kinet, and E. O. Long The SH2 Domain-containing Inositol 5'-Phosphatase (SHIP) Recruits the p85 Subunit of Phosphoinositide 3-Kinase during Fcgamma RIIb1-mediated Inhibition of B Cell Receptor Signaling J. Biol. Chem., March 12, 1999; 274(11): 7489 - 7494. [Abstract] [Full Text] [PDF]
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S. Tridandapani, M. Pradhan, J. R. LaDine, S. Garber, C. L. Anderson, and K. M. Coggeshall Protein Interactions of Src Homology 2 (SH2) Domain-Containing Inositol Phosphatase (SHIP): Association with Shc Displaces SHIP from Fc{gamma}RIIb in B Cells J. Immunol., February 1, 1999; 162(3): 1408 - 1414. [Abstract] [Full Text] [PDF]
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 K. E. Nichols, D. P. Harkin, S. Levitz, M. Krainer, K. A. Kolquist, C. Genovese, A. Bernard, M. Ferguson, L. Zuo, E. Snyder, et al. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome PNAS, November 10, 1998; 95(23): 13765 - 13770. [Abstract] [Full Text] [PDF]
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Q. Liu, A. J. Oliveira-Dos-Santos, S. Mariathasan, D. Bouchard, J. Jones, R. Sarao, I. Kozieradzki, P. S. Ohashi, J. M. Penninger, and D. J. Dumont The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling J. Exp. Med., October 5, 1998; 188(7): 1333 - 1342. [Abstract] [Full Text] [PDF]
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K. Sato and A. Ochi Superclustering of B Cell Receptor and Fc{gamma}RIIB1 Activates Src Homology 2-Containing Protein Tyrosine Phosphatase-1 J. Immunol., September 15, 1998; 161(6): 2716 - 2722. [Abstract] [Full Text] [PDF]
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K. Nakamura and J. C. Cambier B Cell Antigen Receptor (BCR)-Mediated Formation of a SHP-2-pp120 Complex and Its Inhibition by Fe{gamma}RIIB1-BCR Coligation J. Immunol., July 15, 1998; 161(2): 684 - 691. [Abstract] [Full Text] [PDF]
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M. G. Hunter and B. R. Avalos Phosphatidylinositol 3'-Kinase and SH2-Containing Inositol Phosphatase (SHIP) Are Recruited by Distinct Positive and Negative Growth-Regulatory Domains in the Granulocyte Colony-Stimulating Factor Receptor J. Immunol., May 15, 1998; 160(10): 4979 - 4987. [Abstract] [Full Text] [PDF]
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O. Malbec, D. C. Fong, M. Turner, V. L. J. Tybulewicz, J. C. Cambier, W. H. Fridman, and M. Daeron Fc{epsilon} Receptor I-Associated lyn-Dependent Phosphorylation of Fc{gamma} Receptor IIB During Negative Regulation of Mast Cell Activation J. Immunol., February 15, 1998; 160(4): 1647 - 1658. [Abstract] [Full Text] [PDF]
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S. Giuriato, B. Payrastre, A. L. Drayer, M. Plantavid, R. Woscholski, P. Parker, C. Erneux, and H. Chap Tyrosine Phosphorylation and Relocation of SHIP Are Integrin-mediated in Thrombin-stimulated Human Blood Platelets J. Biol. Chem., October 24, 1997; 272(43): 26857 - 26863. [Abstract] [Full Text] [PDF]
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N. Gupta, A. M. Scharenberg, D. N. Burshtyn, N. Wagtmann, M. N. Lioubin, L. R. Rohrschneider, J.-P. Kinet, and E. O. Long Negative Signaling Pathways of the Killer Cell Inhibitory Receptor and Fcgamma RIIb1 Require Distinct Phosphatases J. Exp. Med., August 4, 1997; 186(3): 473 - 478. [Abstract] [Full Text] [PDF]
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T. Kimura, H. Sakamoto, E. Appella, and R. P. Siraganian The Negative Signaling Molecule SH2 Domain-containing Inositol-Polyphosphate 5-Phosphatase (SHIP) Binds to the Tyrosine-phosphorylated beta Subunit of the High Affinity IgE Receptor J. Biol. Chem., May 23, 1997; 272(21): 13991 - 13996. [Abstract] [Full Text] [PDF]
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L. Liu, J. E. Damen, M. D. Ware, and G. Krystal Interleukin-3 Induces the Association of the Inositol 5-Phosphatase SHIP with SHP2 J. Biol. Chem., April 25, 1997; 272(17): 10998 - 11001. [Abstract] [Full Text] [PDF]
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S. J. Geier, P. A. Algate, K. Carlberg, D. Flowers, C. Friedman, B. Trask, and L. R. Rohrschneider The Human SHIP Gene Is Differentially Expressed in Cell Lineages of the Bone Marrow and Blood Blood, March 15, 1997; 89(6): 1876 - 1885. [Abstract] [Full Text] [PDF]
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P. A. Kiener, M. N. Lioubin, L. R. Rohrschneider, J. A. Ledbetter, S. G. Nadler, and M. L. Diegel Co-ligation of the Antigen and Fc Receptors Gives Rise to the Selective Modulation of Intracellular Signaling in B Cells. REGULATION OF THE ASSOCIATION OF PHOSPHATIDYLINOSITOL 3-KINASE AND INOSITOL 5prime -PHOSPHATASE WITH THE ANTIGEN RECEPTOR COMPLEX J. Biol. Chem., February 7, 1997; 272(6): 3838 - 3844. [Abstract] [Full Text] [PDF]
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H. Phee, A. Jacob, and K. M. Coggeshall Enzymatic Activity of the Src Homology 2 Domain-containing Inositol Phosphatase Is Regulated by a Plasma Membrane Location J. Biol. Chem., June 16, 2000; 275(25): 19090 - 19097. [Abstract] [Full Text] [PDF]
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J. C. Poe, M. Fujimoto, P. J. Jansen, A. S. Miller, and T. F. Tedder CD22 Forms a Quaternary Complex with SHIP, Grb2, and Shc. A PATHWAY FOR REGULATION OF B LYMPHOCYTE ANTIGEN RECEPTOR-INDUCED CALCIUM FLUX J. Biol. Chem., June 2, 2000; 275(23): 17420 - 17427. [Abstract] [Full Text] [PDF]
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M. Sattler, S. Verma, Y. B. Pride, R. Salgia, L. R. Rohrschneider, and J. D. Griffin SHIP1, an SH2 Domain Containing Polyinositol-5-phosphatase, Regulates Migration through Two Critical Tyrosine Residues and Forms a Novel Signaling Complex with DOK1 and CRKL J. Biol. Chem., January 19, 2001; 276(4): 2451 - 2458. [Abstract] [Full Text] [PDF]
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D. Saint-Dic, S. C. Chang, G. S. Taylor, M. M. Provot, and T. S. Ross Regulation of the Src Homology 2-containing Inositol 5-Phosphatase SHIP1 in HIP1/PDGFbeta R-transformed Cells J. Biol. Chem., June 8, 2001; 276(24): 21192 - 21198. [Abstract] [Full Text] [PDF]
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F. Mazerolles, C. Barbat, M. Trucy, W. Kolanus, and A. Fischer Molecular Events Associated with CD4-mediated Down-regulation of LFA-1-dependent Adhesion J. Biol. Chem., January 4, 2002; 277(2): 1276 - 1283. [Abstract] [Full Text] [PDF]
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