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The Journal of Immunology, Vol 157, Issue 6 2229-2233, Copyright © 1996 by American Association of Immunologists

CUTTING EDGE

Commentary: A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens

CM Snapper and JJ Mond
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

We provide a model for induction of T cell-independent, polysaccharide- specific Ig secretion in response to bacterial challenge. Two predominant pathways are defined that require the concerted action of multivalent membrane Ig cross-linking by the polysaccharide Ag with 1) various B cell-activating moieties contained within the bacterial pathogen and/or 2) cytokines, such as IFN-gamma and granulocyte- macrophage colony-stimulating factor produced by NK cells and macrophages, that become activated in a T cell-independent manner during bacterial infection.


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