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The Journal of Immunology, Vol 157, Issue 5 2103-2108, Copyright © 1996 by American Association of Immunologists
ARTICLES |
IA Khan and LH Kasper
Department of Medicine, Dartmouth Medical School, Hanover, NH 03755, USA.
Cytokines of the Th1 profile are important mediators of protective host immunity against Toxoplasma gondii infection in mice. In this study we describe the effect of the recently identified cytokine, IL-15, on prevention of murine infection with T. gondii. Administration of exogenous rIL-15 with soluble Toxoplasma lysate Ag (TLA) provides complete protection against a lethal parasite challenge, whereas treatment with either rIL-15 or TLA alone is not protective. Following immunization with TLA/rIL-15, there is a significant proliferation of splenocytes expressing the CD8+ phenotype in response to TLA. A significant rise in the level of serum IFN gamma was observed in vaccinated mice. Adoptive transfer of CD8+ T cells, but not CD4+ T cells, from TLA/rIL-15-vaccinated mice protects naive mice from a lethal parasite challenge. These CD8+ T cells exhibit enhanced CTL activity against target macrophages infected with T. gondii. Mice that have been immunized are protected against lethal parasite challenge for at least 1 mo postvaccination. These observations demonstrate that TLA when administered with exogenous rIL-15 generates toxoplasmacidal Ag- specific CD8+ T cells. These T cells proliferate upon exposure to parasite Ag, exhibit long term memory CTL against infected target cells, and may be involved in host immune memory to this parasite.
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K. H. Ely, L. H. Kasper, and I. A. Khan Augmentation of the CD8+ T Cell Response by IFN-{gamma} in IL-12-Deficient Mice During Toxoplasma gondii Infection J. Immunol., May 1, 1999; 162(9): 5449 - 5454. [Abstract] [Full Text] [PDF]
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K. Hirose, H. Suzuki, H. Nishimura, A. Mitani, J. Washizu, T. Matsuguchi, and Y. Yoshikai Interleukin-15 May Be Responsible for Early Activation of Intestinal Intraepithelial Lymphocytes after Oral Infection with Listeria monocytogenes in Rats Infect. Immun., December 1, 1998; 66(12): 5677 - 5683. [Abstract] [Full Text] [PDF]
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I. A. Khan, T. Matsuura, and L. H. Kasper Inducible Nitric Oxide Synthase Is Not Required for Long-Term Vaccine-Based Immunity Against Toxoplasma gondii J. Immunol., September 15, 1998; 161(6): 2994 - 3000. [Abstract] [Full Text] [PDF]
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I. A. Khan, J. D. Schwartzman, T. Matsuura, and L. H. Kasper A dichotomous role for nitric oxide during acute Toxoplasma gondii infection in mice PNAS, December 9, 1997; 94(25): 13955 - 13960. [Abstract] [Full Text] [PDF]
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C. Agostini, L. Trentin, R. Sancetta, M. Facco, C. Tassinari, A. Cerutti, M. Bortolin, A. Milani, M. Siviero, R. Zambello, et al. Interleukin-15 Triggers Activation and Growth of the CD8 T-Cell Pool in Extravascular Tissues of Patients With Acquired Immunodeficiency Syndrome Blood, August 1, 1997; 90(3): 1115 - 1123. [Abstract] [Full Text] [PDF]
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