The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strobl, H.
Right arrow Articles by Knapp, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strobl, H.
Right arrow Articles by Knapp, W.

The Journal of Immunology, Vol 157, Issue 4 1499-1507, Copyright © 1996 by American Association of Immunologists

ARTICLES

TGF-beta 1 promotes in vitro development of dendritic cells from CD34+ hemopoietic progenitors

H Strobl, E Riedl, C Scheinecker, C Bello-Fernandez, WF Pickl, K Rappersberger, O Majdic and W Knapp
Institute of Immunology, Vienna International Research Cooperation Center (VIRCC) at Sandoz Forschungsinstitut, University of Vienna, Austria.

Several studies have demonstrated that dendritic cells (DC) can be generated in vitro from CD34+ hemopoietic progenitor cells. The growth requirements for these cells are poorly characterized, however. In particular, undefined serum/plasma components seem to significantly contribute to in vitro DC development. We report here that the cytokine combination granulocyte-macrophage CSF (GM-CSF) plus TNF-alpha and stem cell factor (SCF) commonly used for the in vitro generation of DC in serum/plasma-supplemented medium is, in the absence of serum supplementation, very inefficient in inducing DC development. We further demonstrate that supplementation with TGF-beta 1 is required for substantial DC development to occur in the absence of serum. Culture of CD34+ cells under serum-free conditions with TGF-beta 1 plus GM-CSF, TNF-alpha, and SCF strongly induces DC differentiation. This culture condition is even more efficient than culturing CD34+ cells with GM-CSF plus TNF-alpha and SCF in the presence of cord blood plasma. The proportions and total yields of cells with typical DC morphology and CD1a molecule expression are higher. The allostimulatory capacity of DC from TGF-beta 1-supplemented, cultures exceeds allostimulation by cells grown in plasma-containing medium. Substantial numbers (21 +/- 7%) of cells grown in TGF-beta 1-supplemented, but not plasma-supplemented, cultures express the Birbeck granule marker molecule Lag and display numerous Birbeck granules. Cells with distinct monocytic features are less frequently observed in TGF-beta 1- supplemented serum-free cultures. The addition of neutralizing anti-TGF- beta 1 Ab abrogates the observed TGF-beta 1 effects.


This article has been cited by other articles:


Home page
 BrainHome page
I. Ifergan, H. Kebir, M. Bernard, K. Wosik, A. Dodelet-Devillers, R. Cayrol, N. Arbour, and A. Prat
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells
Brain, March 1, 2008; 131(3): 785 - 799.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. H. Kaplan, M. O. Li, M. C. Jenison, W. D. Shlomchik, R. A. Flavell, and M. J. Shlomchik
Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells
J. Exp. Med., October 29, 2007; 204(11): 2545 - 2552.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Li, S. Abediankenari, Y.-J. Kim, T. B. Campbell, S. Ito, B. Graham-Evans, S. Cooper, and H. E. Broxmeyer
TGF-{beta} combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors
Blood, October 15, 2007; 110(8): 2872 - 2879.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Jorgl, B. Platzer, S. Taschner, L. X. Heinz, B. Hocher, P. M. Reisner, F. Gobel, and H. Strobl
Human Langerhans-cell activation triggered in vitro by conditionally expressed MKK6 is counterregulated by the downstream effector RelB
Blood, January 1, 2007; 109(1): 185 - 193.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. W. Lee, L. Hertel, R. K. Louie, T. Burster, V. Lacaille, A. Pashine, D. A. Abate, E. S. Mocarski, and E. D. Mellins
Human Cytomegalovirus Alters Localization of MHC Class II and Dendrite Morphology in Mature Langerhans Cells
J. Immunol., September 15, 2006; 177(6): 3960 - 3971.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Bellone, A. Carbone, C. Smirne, T. Scirelli, A. Buffolino, A. Novarino, A. Stacchini, O. Bertetto, G. Palestro, C. Sorio, et al.
Cooperative induction of a tolerogenic dendritic cell phenotype by cytokines secreted by pancreatic carcinoma cells.
J. Immunol., September 1, 2006; 177(5): 3448 - 3460.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. Bechetoille, V. Andre, J. Valladeau, E. Perrier, and C. Dezutter-Dambuyant
Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuli
J. Leukoc. Biol., July 1, 2006; 80(1): 45 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Ito, Y. Minamiya, H. Kawai, S. Saito, H. Saito, T. Nakagawa, K. Imai, M. Hirokawa, and J.-i. Ogawa
Tumor-Derived TGFbeta-1 Induces Dendritic Cell Apoptosis in the Sentinel Lymph Node
J. Immunol., May 1, 2006; 176(9): 5637 - 5643.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. I. Slukvin, M. A. Vodyanik, J. A. Thomson, M. E. Gumenyuk, and K.-D. Choi
Directed Differentiation of Human Embryonic Stem Cells into Functional Dendritic Cells through the Myeloid Pathway.
J. Immunol., March 1, 2006; 176(5): 2924 - 2932.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. X. Heinz, B. Platzer, P. M. Reisner, A. Jorgl, S. Taschner, F. Gobel, and H. Strobl
Differential involvement of PU.1 and Id2 downstream of TGF-beta1 during Langerhans-cell commitment
Blood, February 15, 2006; 107(4): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. Gautier, B. de Saint-Vis, B. Senechal, J.-J. Pin, E. E.M. Bates, C. Caux, F. Geissmann, and P. Garrone
The Class 6 Semaphorin SEMA6A Is Induced by Interferon-{gamma} and Defines an Activation Status of Langerhans Cells Observed in Pathological Situations
Am. J. Pathol., February 1, 2006; 168(2): 453 - 465.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Rossi and J. W. Young
Human Dendritic Cells: Potent Antigen-Presenting Cells at the Crossroads of Innate and Adaptive Immunity
J. Immunol., August 1, 2005; 175(3): 1373 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Patterson, H. Donaghy, P. Amjadi, B. Gazzard, F. Gotch, and P. Kelleher
Human BDCA-1-Positive Blood Dendritic Cells Differentiate into Phenotypically Distinct Immature and Mature Populations in the Absence of Exogenous Maturational Stimuli: Differentiation Failure in HIV Infection
J. Immunol., June 15, 2005; 174(12): 8200 - 8209.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Menges, T. Baumeister, S. Rossner, P. Stoitzner, N. Romani, A. Gessner, and M. B. Lutz
IL-4 supports the generation of a dendritic cell subset from murine bone marrow with altered endocytosis capacity
J. Leukoc. Biol., April 1, 2005; 77(4): 535 - 543.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Chang-Rodriguez, W. Hoetzenecker, C. Schwarzler, T. Biedermann, S. Saeland, and A. Elbe-Burger
Fetal and neonatal murine skin harbors Langerhans cell precursors
J. Leukoc. Biol., March 1, 2005; 77(3): 352 - 360.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. A. Lyakh, M. Sanford, S. Chekol, H. A. Young, and A. B. Roberts
TGF-{beta} and Vitamin D3 Utilize Distinct Pathways to Suppress IL-12 Production and Modulate Rapid Differentiation of Human Monocytes into CD83+ Dendritic Cells
J. Immunol., February 15, 2005; 174(4): 2061 - 2070.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Platzer, A. Jorgl, S. Taschner, B. Hocher, and H. Strobl
RelB regulates human dendritic cell subset development by promoting monocyte intermediates
Blood, December 1, 2004; 104(12): 3655 - 3663.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
A. Encabo, P. Solves, E. Mateu, P. Sepulveda, F. Carbonell-Uberos, and M. D. Minana
Selective Generation of Different Dendritic Cell Precursors from CD34+ Cells by Interleukin-6 and Interleukin-3
Stem Cells, September 1, 2004; 22(5): 725 - 740.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Ratzinger, J. Baggers, M. A. de Cos, J. Yuan, T. Dao, J. L. Reagan, C. Munz, G. Heller, and J. W. Young
Mature Human Langerhans Cells Derived from CD34+ Hematopoietic Progenitors Stimulate Greater Cytolytic T Lymphocyte Activity in the Absence of Bioactive IL-12p70, by Either Single Peptide Presentation or Cross-Priming, Than Do Dermal-Interstitial or Monocyte-Derived Dendritic Cells
J. Immunol., August 15, 2004; 173(4): 2780 - 2791.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Hertel, V. G. Lacaille, H. Strobl, E. D. Mellins, and E. S. Mocarski
Susceptibility of Immature and Mature Langerhans Cell-Type Dendritic Cells to Infection and Immunomodulation by Human Cytomegalovirus
J. Virol., July 1, 2003; 77(13): 7563 - 7574.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Ratzinger, J. L. Reagan, G. Heller, K. J. Busam, and J. W. Young
Differential CD52 expression by distinct myeloid dendritic cell subsets: implications for alemtuzumab activity at the level of antigen presentation in allogeneic graft-host interactions in transplantation
Blood, February 15, 2003; 101(4): 1422 - 1429.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Beaulieu, D. F. Robbiani, X. Du, E. Rodrigues, R. Ignatius, Y. Wei, P. Ponath, J. W. Young, M. Pope, R. M. Steinman, et al.
Expression of a Functional Eotaxin (CC Chemokine Ligand 11) Receptor CCR3 by Human Dendritic Cells
J. Immunol., September 15, 2002; 169(6): 2925 - 2936.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
F. Geissmann, M.C. Dieu-Nosjean, C. Dezutter, J. Valladeau, S. Kayal, M. Leborgne, N. Brousse, S. Saeland, and J. Davoust
Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin
J. Exp. Med., August 19, 2002; 196(4): 417 - 430.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
G. Guironnet, C. Dezutter-Dambuyant, C. V. N. Bechetoille, D. Schmitt, and J. Peguet-Navarro
Antagonistic effects of IL-4 and TGF-{beta}1 on Langerhans cell-related antigen expression by human monocytes
J. Leukoc. Biol., May 1, 2002; 71(5): 845 - 853.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-C. Dieu-Nosjean, C. Massacrier, B. Vanbervliet, W.-H. Fridman, and C. Caux
IL-10 Induces CCR6 Expression During Langerhans Cell Development While IL-4 and IFN-{gamma} Suppress It
J. Immunol., November 15, 2001; 167(10): 5594 - 5602.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. Mohamadzadeh, F. Berard, G. Essert, C. Chalouni, B. Pulendran, J. Davoust, G. Bridges, A. K. Palucka, and J. Banchereau
Interleukin 15 Skews Monocyte Differentiation into Dendritic Cells with Features of Langerhans Cells
J. Exp. Med., October 1, 2001; 194(7): 1013 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
G. M. Halliday and S. Le
Transforming growth factor-{beta} produced by progressor tumors inhibits, while IL-10 produced by regressor tumors enhances, Langerhans cell migration from skin
Int. Immunol., September 1, 2001; 13(9): 1147 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
H. Hemmi, M. Yoshino, H. Yamazaki, M. Naito, T. Iyoda, Y. Omatsu, S. Shimoyama, J. J. Letterio, T. Nakabayashi, H. Tagaya, et al.
Skin antigens in the steady state are trafficked to regional lymph nodes by transforming growth factor-{beta}1-dependent cells
Int. Immunol., May 1, 2001; 13(5): 695 - 704.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Geissmann, P. Launay, B. Pasquier, Y. Lepelletier, M. Leborgne, A. Lehuen, N. Brousse, and R. C. Monteiro
A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes
J. Immunol., January 1, 2001; 166(1): 346 - 352.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Riedl, J. Stockl, O. Majdic, C. Scheinecker, W. Knapp, and H. Strobl
Ligation of E-cadherin on in vitro-generated immature Langerhans-type dendritic cells inhibits their maturation
Blood, December 15, 2000; 96(13): 4276 - 4284.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Spanbroek, M. Hildner, D. Steinhilber, N. Fusenig, K. Yoneda, O. R. B. Samuelsson, and A. J.R. Habenicht
5-lipoxygenase expression in dendritic cells generated from CD34+ hematopoietic progenitors and in lymphoid organs
Blood, December 1, 2000; 96(12): 3857 - 3865.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. O. Fortunel, A. Hatzfeld, and J. A. Hatzfeld
Transforming growth factor-beta : pleiotropic role in the regulation of hematopoiesis
Blood, September 15, 2000; 96(6): 2022 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M.-C. Dieu-Nosjean, C. Massacrier, B. Homey, B. Vanbervliet, J.-J. Pin, A. Vicari, S. Lebecque, C. Dezutter-Dambuyant, D. Schmitt, A. Zlotnik, et al.
Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors
J. Exp. Med., September 5, 2000; 192(5): 705 - 718.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Riedl, J. Stockl, O. Majdic, C. Scheinecker, K. Rappersberger, W. Knapp, and H. Strobl
Functional Involvement of E-Cadherin in TGF-{beta}1-Induced Cell Cluster Formation of In Vitro Developing Human Langerhans-Type Dendritic Cells
J. Immunol., August 1, 2000; 165(3): 1381 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. D. Mills, K. Kincaid, J. M. Alt, M. J. Heilman, and A. M. Hill
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
J. Immunol., June 15, 2000; 164(12): 6166 - 6173.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi
TGF-{beta}1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors
J. Immunol., March 1, 2000; 164(5): 2285 - 2295.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
M. Brenner, C. Rossig, U. Sili, J. W. Young, and E. Goulmy
Transfusion Medicine: New Clinical Applications of Cellular Immunotherapy
Hematology, January 1, 2000; 2000(1): 356 - 375.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Zhang, Y. Zhang, Y. Wang, M. Ogata, S.-i. Hashimoto, N. Onai, and K. Matsushima
Development of dendritic cells in vitro from murine fetal liver-derived lineage phenotype-negative c-kit+ hematopoietic progenitor cells
Blood, January 1, 2000; 95(1): 138 - 146.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Jaksits, E. Kriehuber, A. S. Charbonnier, K. Rappersberger, G. Stingl, and D. Maurer
CD34+ Cell-Derived CD14+ Precursor Cells Develop into Langerhans Cells in a TGF-{beta}1-Dependent Manner
J. Immunol., November 1, 1999; 163(9): 4869 - 4877.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Ito, M. Inaba, K. Inaba, J. Toki, S. Sogo, T. Iguchi, Y. Adachi, K. Yamaguchi, R. Amakawa, J. Valladeau, et al.
A CD1a+/CD11c+ Subset of Human Blood Dendritic Cells Is a Direct Precursor of Langerhans Cells
J. Immunol., August 1, 1999; 163(3): 1409 - 1419.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
M. Ishikawa, Y. Jin, H. Guo, H. Link, and B.-G. Xiao
Nasal administration of transforming growth factor-{beta}1 induces dendritic cells and inhibits protracted-relapsing experimental allergic encephalomyelitis
Multiple Sclerosis, June 1, 1999; 5(3): 184 - 191.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
F. Geissmann, P. Revy, A. Regnault, Y. Lepelletier, M. Dy, N. Brousse, S. Amigorena, O. Hermine, and A. Durandy
TGF-{beta}1 Prevents the Noncognate Maturation of Human Dendritic Langerhans Cells
J. Immunol., April 15, 1999; 162(8): 4567 - 4575.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Zhang, Y.-y. Zhang, M. Ogata, P. Chen, A. Harada, S.-i. Hashimoto, and K. Matsushima
Transforming Growth Factor-beta 1 Polarizes Murine Hematopoietic Progenitor Cells to Generate Langerhans Cell-Like Dendritic Cells Through a Monocyte/Macrophage Differentiation Pathway
Blood, February 15, 1999; 93(4): 1208 - 1220.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Menetrier-Caux, G. Montmain, M.C. Dieu, C. Bain, M.C. Favrot, C. Caux, and J.Y. Blay
Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor
Blood, December 15, 1998; 92(12): 4778 - 4791.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
E. A. de Wynter, D. Buck, C. Hart, R. Heywood, L.H. Coutinho, A. Clayton, J.A. Rafferty, D. Burt, G. Guenechea, J. A. Bueren, et al.
CD34+AC133+ Cells Isolated from Cord Blood are Highly Enriched in Long-Term Culture-Initiating Cells, NOD/SCID-Repopulating Cells and Dendritic Cell Progenitors
Stem Cells, November 1, 1998; 16(6): 387 - 396.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
A. Kocikova, A. Kolesaric, F. Koszik, G. Stingl, and A. Elbe-Burger
Murine Langerhans Cells Cultured Under Serum-Free Conditions Mature into Potent Stimulators of Primary Immune Responses In Vitro and In Vivo
J. Immunol., October 15, 1998; 161(8): 4033 - 4041.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Varas, A. Vicente, R. Sacedon, and A. G. Zapata
Interleukin-7 Influences the Development of Thymic Dendritic Cells
Blood, July 1, 1998; 92(1): 93 - 100.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. M. Frey, N. R. Hackett, J. M. Bergelson, R. Finberg, R. G. Crystal, M. A.S. Moore, and S. Rafii
High-Efficiency Gene Transfer Into Ex Vivo Expanded Human Hematopoietic Progenitors and Precursor Cells by Adenovirus Vectors
Blood, April 15, 1998; 91(8): 2781 - 2792.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. D. Miralles, C. A. Smith, L. P. Whichard, M. A. Morse, B. F. Haynes, and D. D. Patel
CD34+CD38-lin- Cord Blood Cells Develop into Dendritic Cells in Human Thymic Stromal Monolayers and Thymic Nodules
J. Immunol., April 1, 1998; 160(7): 3290 - 3298.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Salomon, J. L. Cohen, C. Masurier, and D. Klatzmann
Three Populations of Mouse Lymph Node Dendritic Cells with Different Origins and Dynamics
J. Immunol., January 15, 1998; 160(2): 708 - 717.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Shortman and C. Caux
Dendritic Cell Development: Multiple Pathways to Nature's Adjuvants
Stem Cells, November 1, 1997; 15(6): 409 - 419.
[Abstract] [Full Text]

Home page
 BloodHome page
D. N.J. Hart
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
Blood, November 1, 1997; 90(9): 3245 - 3287.
[Full Text] [PDF]

Home page
 J. Exp. Med.Home page
G. Schuler and R.M. Steinman
Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors
J. Exp. Med., October 20, 1997; 186(8): 1183 - 1187.
[Full Text] [PDF]

Home page
 BloodHome page
H. Strobl, C. Bello-Fernandez, E. Riedl, W. F. Pickl, O. Majdic, S. D. Lyman, and W. Knapp
flt3 Ligand in Cooperation With Transforming Growth Factor-beta 1 Potentiates In Vitro Development of Langerhans-Type Dendritic Cells and Allows Single-Cell Dendritic Cell Cluster Formation Under Serum-Free Conditions
Blood, August 15, 1997; 90(4): 1425 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
O. Parolini, S. Berardelli, E. Riedl, C. Bello-Fernandez, H. Strobl, O. Majdic, and W. Knapp
Expression of Wiskott-Aldrich Syndrome Protein (WASP) Gene During Hematopoietic Differentiation
Blood, July 1, 1997; 90(1): 70 - 75.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. Strunk, C. Egger, G. Leitner, D. Hanau, and G. Stingl
A Skin Homing Molecule Defines the Langerhans Cell Progenitor in Human Peripheral Blood
J. Exp. Med., March 17, 1997; 185(6): 1131 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
Y. Yamaguchi, H. Tsumura, M. Miwa, and K. Inaba
Contrasting Effects of TGF-{beta}1 and TNF-{alpha} on the Development of Dendritic Cells from Progenitors in Mouse Bone Marrow
Stem Cells, March 1, 1997; 15(2): 144 - 153.
[Abstract] [Full Text]

Home page
 J. Exp. Med.Home page
T. A. Borkowski, J. J. Letterio, A. G. Farr, and M. C. Udey
A Role for Endogenous Transforming Growth Factor beta 1 in Langerhans Cell Biology:  The Skin of   Transforming Growth Factor beta 1 Null Mice Is Devoid of  Epidermal Langerhans Cells
J. Exp. Med., December 15, 1996; 184(6): 2417 - 2422.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.