| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 4 1440-1447, Copyright © 1996 by American Association of Immunologists
ARTICLES |
YY Li, M Baccam, SB Waters, JE Pessin, GA Bishop and GA Koretzky
Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City 52242, USA.
CD40 is a 45- to 50-kDa transmembrane glycoprotein that plays an important role in B cell proliferation, survival, memory, and Ig isotype switching. How CD40 engagement couples to these distal events in B cell activation remains poorly understood. In this study, we have examined signal transduction events mediated by CD40 cross-linking in resting murine splenic B cells. In comparison to signaling via the B cell Ag receptor (BCR), CD40 cross-linking was less effective at activating protein tyrosine kinases. Interestingly, however, CD40 engagement resulted in the phosphorylation of both extracellular signal- regulated protein kinase (ERK) and the Ras guanine nucleotide exchange factor, Son of sevenless. In addition, both ERK and c-Jun NH2-terminal kinase activities were increased after both CD40 and BCR ligation. Overnight treatment of cells with phorbol ester as well as pharmacologic inhibitors of protein kinase C abrogated these signaling events after BCR treatment; however, no effect was seen on CD40- mediated activation of ERK or c-Jun NH2-terminal kinase, suggesting that the BCR and CD40 differentially utilize protein kinase C to couple with these signaling pathways.
This article has been cited by other articles:
|
|
 |
|
  J. M. Polo, W. Ci, J. D. Licht, and A. Melnick Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells Blood, August 1, 2008; 112(3): 644 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Homig-Holzel, C. Hojer, J. Rastelli, S. Casola, L. J. Strobl, W. Muller, L. Quintanilla-Martinez, A. Gewies, J. Ruland, K. Rajewsky, et al. Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-{kappa}B pathway and promotes lymphomagenesis J. Exp. Med., June 9, 2008; 205(6): 1317 - 1329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Dye, A. Palvanov, B. Guo, and T. L. Rothstein B Cell Receptor Cross-Talk: Exposure to Lipopolysaccharide Induces an Alternate Pathway for B Cell Receptor-Induced ERK Phosphorylation and NF-{kappa}B Activation J. Immunol., July 1, 2007; 179(1): 229 - 235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Thusberg and M. Vihinen The structural basis of hyper IgM deficiency - CD40L mutations Protein Eng. Des. Sel., March 1, 2007; 20(3): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Munroe and G. A. Bishop A Costimulatory Function for T Cell CD40 J. Immunol., January 15, 2007; 178(2): 671 - 682. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Davies, T. W. Mak, L. S. Young, and A. G. Eliopoulos TRAF6 Is Required for TRAF2-Dependent CD40 Signal Transduction in Nonhemopoietic Cells Mol. Cell. Biol., November 15, 2005; 25(22): 9806 - 9819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yang, H. Hase, D. Legarda-Addison, L. Varughese, B. Seed, and A. T. Ting B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells J. Immunol., September 1, 2005; 175(5): 2814 - 2824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Guo and T. L. Rothstein B Cell Receptor (BCR) Cross-Talk: IL-4 Creates an Alternate Pathway for BCR-Induced ERK Activation That Is Phosphatidylinositol 3-Kinase Independent J. Immunol., May 1, 2005; 174(9): 5375 - 5381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mizuno and T. L. Rothstein B Cell Receptor (BCR) Cross-Talk: CD40 Engagement Enhances BCR-Induced ERK Activation J. Immunol., March 15, 2005; 174(6): 3369 - 3376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Galindo, A. A. Fadl, J. Sha, and A. K. Chopra Microarray Analysis of Aeromonas hydrophila Cytotoxic Enterotoxin-Treated Murine Primary Macrophages Infect. Immun., September 1, 2004; 72(9): 5439 - 5445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Flaxenburg, M. Melter, P. H. Lapchak, D. M. Briscoe, and S. Pal The CD40-Induced Signaling Pathway in Endothelial Cells Resulting in the Overexpression of Vascular Endothelial Growth Factor Involves Ras and Phosphatidylinositol 3-Kinase J. Immunol., June 15, 2004; 172(12): 7503 - 7509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Reyes-Moreno, J. Girouard, R. Lapointe, A. Darveau, and W. Mourad CD40/CD40 Homodimers Are Required for CD40-induced Phosphatidylinositol 3-Kinase-dependent Expression of B7.2 by Human B Lymphocytes J. Biol. Chem., February 27, 2004; 279(9): 7799 - 7806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-F. Lu, W. J. Cook, L.-L. Lin, and R. J. Noelle CD40 Signaling through a Newly Identified Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) Binding Site J. Biol. Chem., November 14, 2003; 278(46): 45414 - 45418. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Haxhinasto and G. A. Bishop A Novel Interaction between Protein Kinase D and TNF Receptor-Associated Factor Molecules Regulates B Cell Receptor-CD40 Synergy J. Immunol., November 1, 2003; 171(9): 4655 - 4662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Jinquan, H. H. Jacobi, C. Jing, A. Millner, E. Sten, L. Hviid, L. Anting, L. P. Ryder, C. Glue, P. S. Skov, et al. CCR3 Expression Induced by IL-2 and IL-4 Functioning as a Death Receptor for B Cells J. Immunol., August 15, 2003; 171(4): 1722 - 1731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Baccam, S.-Y. Woo, C. Vinson, and G. A. Bishop CD40-Mediated Transcriptional Regulation of the IL-6 Gene in B Lymphocytes: Involvement of NF-{kappa}B, AP-1, and C/EBP J. Immunol., March 15, 2003; 170(6): 3099 - 3108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yamada, D. Zhu, A. Saxon, and K. Zhang CD45 Controls Interleukin-4-mediated IgE Class Switch Recombination in Human B Cells through Its Function as a Janus Kinase Phosphatase J. Biol. Chem., August 2, 2002; 277(32): 28830 - 28835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dadgostar, B. Zarnegar, A. Hoffmann, X.-F. Qin, U. Truong, G. Rao, D. Baltimore, and G. Cheng Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes PNAS, February 5, 2002; 99(3): 1497 - 1502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Li, C. Torres, C. Acuna-Castillo, R. Walter, E. M. Gardner, D. M. Murasko, and F. Sierra Defect in ERK2 and p54JNK Activation in Aging Mouse Splenocytes J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2002; 57(2): B41 - 47. [Abstract] [Full Text]
|
|
|
|
|
|
N. Zhu, L. M. Ramirez, R. L. Lee, N. S. Magnuson, G. A. Bishop, and M. R. Gold CD40 Signaling in B Cells Regulates the Expression of the Pim-1 Kinase Via the NF-{kappa}B Pathway J. Immunol., January 15, 2002; 168(2): 744 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grassme, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins Ceramide-Rich Membrane Rafts Mediate CD40 Clustering J. Immunol., January 1, 2002; 168(1): 298 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Wu, C. Venkataraman, S. Estus, C. Dong, R. J. Davis, R. A. Flavell, and S. Bondada Positive Signaling Through CD72 Induces Mitogen-Activated Protein Kinase Activation and Synergizes with B Cell Receptor Signals to Induce X-Linked Immunodeficiency B Cell Proliferation J. Immunol., August 1, 2001; 167(3): 1263 - 1273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Richards, S. H. Dave, C.-H. G. Chou, A. A. Mamchak, and A. L. DeFranco Inhibition of the MEK/ERK Signaling Pathway Blocks a Subset of B Cell Responses to Antigen J. Immunol., March 15, 2001; 166(6): 3855 - 3864. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Pearson, B. E. Castle, and M. R. Kehry CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways Int. Immunol., March 1, 2001; 13(3): 273 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Bishop, Y. Hsing, B. S. Hostager, S. V. Jalukar, L. M. Ramirez, and M. A. Tomai Molecular Mechanisms of B Lymphocyte Activation by the Immune Response Modifier R-848 J. Immunol., November 15, 2000; 165(10): 5552 - 5557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Swart, D. M. Bergeron, and T. C. Chiles Identification of a Membrane Ig-Induced p38 Mitogen-Activated Protein Kinase Module That Regulates cAMP Response Element Binding Protein Phosphorylation and Transcriptional Activation in CH31 B Cell Lymphomas J. Immunol., March 1, 2000; 164(5): 2311 - 2319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shirakata, K. Ishii, H. Yagita, K. Okumura, M. Taniguchi, and T. Takemori Distinct Subcellular Localization and Substrate Specificity of Extracellular Signal-Regulated Kinase in B Cells upon Stimulation with IgM and CD40 J. Immunol., December 15, 1999; 163(12): 6589 - 6597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tan, T. Town, M. Saxe, D. Paris, Y. Wu, and M. Mullan Ligation of Microglial CD40 Results in p44/42 Mitogen-Activated Protein Kinase-Dependent TNF-{alpha} Production That Is Opposed by TGF-{beta}1 and IL-10 J. Immunol., December 15, 1999; 163(12): 6614 - 6621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Aicher, G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells J. Immunol., December 1, 1999; 163(11): 5786 - 5795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Posner, L. A. Cavacini, M. P. Upton, K. C. Tillman, E. R. Gornstein, and C. M. Norris Jr. Surface Membrane-expressed CD40 Is Present on Tumor Cells from Squamous Cell Cancer of the Head and Neck in Vitro and in Vivo and Regulates Cell Growth in Tumor Cell Lines Clin. Cancer Res., August 1, 1999; 5(8): 2261 - 2270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-M. Park, H.-S. Kim, J. Choe, and T. H. Lee Differential Induction of Cytokine Genes and Activation of Mitogen-Activated Protein Kinase Family by Soluble CD40 Ligand and TNF in a Human Follicular Dendritic Cell Line J. Immunol., July 15, 1999; 163(2): 631 - 638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Nakamura, A. Kawakami, S. Yamasaki, Y. Kawabe, T. Nakamura, and K. Eguchi Expression of mitogen activated protein kinases in labial salivary glands of patients with Sjogren's syndrome Ann Rheum Dis, June 1, 1999; 58(6): 382 - 385. [Abstract] [Full Text]
|
|
|
|
|
|
K. Siemasko, B. J. Eisfelder, C. Stebbins, S. Kabak, A. J. Sant, W. Song, and M. R. Clark Ig{alpha} and Ig{beta} Are Required for Efficient Trafficking to Late Endosomes and to Enhance Antigen Presentation J. Immunol., June 1, 1999; 162(11): 6518 - 6525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Suttles, D. M. Milhorn, R. W. Miller, J. C. Poe, L. M. Wahl, and R. D. Stout CD40 Signaling of Monocyte Inflammatory Cytokine Synthesis through an ERK1/2-dependent Pathway. A TARGET OF INTERLEUKIN ()-4 AND IL-10 ANTI-INFLAMMATORY ACTION J. Biol. Chem., February 26, 1999; 274(9): 5835 - 5842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Tognon, H. E. Kirk, L. A. Passmore, I. P. Whitehead, C. J. Der, and R. J. Kay Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain Mol. Cell. Biol., December 1, 1998; 18(12): 6995 - 7008. [Abstract] [Full Text]
|
|
|
|
|
|
X. Li and R. H. Carter Convergence of CD19 and B Cell Antigen Receptor Signals at MEK1 in the ERK2 Activation Cascade J. Immunol., December 1, 1998; 161(11): 5901 - 5908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hashimoto, H. Okada, A. Jiang, M. Kurosaki, S. Greenberg, E. A. Clark, and T. Kurosaki Involvement of Guanosine Triphosphatases and Phospholipase C-gamma 2 in Extracellular Signal-regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor J. Exp. Med., October 5, 1998; 188(7): 1287 - 1295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Lazaar, Y. Amrani, J. Hsu, R. A. Panettieri Jr., W. C. Fanslow, S. M. Albelda, and E. Pure CD40-Mediated Signal Transduction in Human Airway Smooth Muscle J. Immunol., September 15, 1998; 161(6): 3120 - 3127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Lee and G. A. Koretzky Extracellular Signal-Regulated Kinase-2, But Not c-Jun NH2-Terminal Kinase, Activation Correlates with Surface IgM-Mediated Apoptosis in the WEHI 231 B Cell Line J. Immunol., August 15, 1998; 161(4): 1637 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Grammer, J. L. Swantek, R. D. McFarland, Y. Miura, T. Geppert, and P. E. Lipsky TNF Receptor-Associated Factor-3 Signaling Mediates Activation of p38 and Jun N-Terminal Kinase, Cytokine Secretion, and Ig Production Following Ligation of CD40 on Human B Cells J. Immunol., August 1, 1998; 161(3): 1183 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. W.F. Chan, I. Mecklenbrauker, I-h. Su, G. Texido, M. Leitges, R. Carsetti, C. A. Lowell, K. Rajewsky, K. Miyake, and A. Tarakhovsky The Molecular Mechanism of B Cell Activation by toll-like Receptor Protein RP-105 J. Exp. Med., July 1, 1998; 188(1): 93 - 101. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, S. Okada, J. E. Pessin, and G. A. Koretzky Insulin Receptor-mediated Dissociation of Grb2 from Sos Involves Phosphorylation of Sos by Kinase(s) Other than Extracellular Signal-regulated Kinase J. Biol. Chem., May 15, 1998; 273(20): 12061 - 12067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Purkerson and D. C. Parker Differential Coupling of Membrane Ig and CD40 to the Extracellularly Regulated Kinase Signaling Pathway J. Immunol., March 1, 1998; 160(5): 2121 - 2129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kozono, R. Abe, H. Kozono, R. G. Kelly, T. Azuma, and V. M. Holers Cross-Linking CD21/CD35 or CD19 Increases Both B7-1 and B7-2 Expression on Murine Splenic B Cells J. Immunol., February 15, 1998; 160(4): 1565 - 1572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kashiwada, Y. Shirakata, J.-I. Inoue, H. Nakano, K. Okazaki, K. Okumura, T. Yamamoto, H. Nagaoka, and T. Takemori Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Stimulates Extracellular Signal-regulated Kinase (ERK) Activity in CD40 Signaling Along a Ras-independent Pathway J. Exp. Med., January 19, 1998; 187(2): 237 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhao, Y.-Y. Li, R. V. Fucini, S. E. Ross, J. E. Pessin, and G. A. Koretzky T Cell Receptor-induced Phosphorylation of Sos Requires Activity of CD45, Lck, and Protein Kinase C, but Not ERK J. Biol. Chem., August 22, 1997; 272(34): 21625 - 21634. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
