The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lack, G.
Right arrow Articles by Gelfand, E. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lack, G.
Right arrow Articles by Gelfand, E. W.

The Journal of Immunology, Vol 157, Issue 4 1432-1439, Copyright © 1996 by American Association of Immunologists

ARTICLES

Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice

G Lack, KL Bradley, E Hamelmann, H Renz, J Loader, DY Leung, G Larsen and EW Gelfand
Department of Pediatrics, National Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.

The effects of nebulized IFN-gamma on primary and secondary IgE production and development of airway hyper-responsiveness (AHR) were investigated. BALB/c mice received primary exposure to aerosolized OVA daily for 10 days and developed anti-OVA IgE responses, immediate cutaneous reactivity to OVA, and altered airway function when assayed on day 12. After secondary exposure to OVA challenges on days 30 and 31, these mice developed an amplified IgE response, heightened cutaneous reactivity to OVA and AHR when measured on day 37. Administration of IFN-gamma for 13 days, beginning 3 days prior to and during primary OVA sensitization, resulted in a decrease in anti-OVA IgE, increases in serum anti-OVA IgG2a levels, a decrease in cutaneous reactivity to OVA, and normal airway function when assessed on day 12 after primary sensitization. This treatment also prevented the development of secondary anti-OVA IgE responses and altered airway responsiveness but did not induce a secondary rise in anti-OVA IgG2a in the serum measured on day 37. Treatment with IFN-gamma on days 26 to 30, well after primary responses were established but just prior to secondary OVA challenge, abolished the development of secondary anti- OVA IgE responses, resulted in an increase in anti-OVA IgG2a in the serum, and prevented the development of AHR. In vitro, CD4+ T cells obtained from OVA-sensitized mice treated with either "early" or "late" IFN-gamma inhibited IgE production. Delivery of IFN-gamma to the airways can prevent secondary allergen sensitization even after primary sensitization has been achieved and this effect is mediated by CD4+ T cells.


This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
M. Okamoto, K. Takeda, A. Joetham, H. Ohnishi, H. Matsuda, C. H. Swasey, B. J. Swanson, K. Yasutomo, A. Dakhama, and E. W. Gelfand
Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation
J. Exp. Med., May 12, 2008; 205(5): 1087 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Q. Wu, R. J. Martin, J. G. Rino, S. Jeyaseelan, R. Breed, and H. W. Chu
A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice
Am J Physiol Lung Cell Mol Physiol, May 1, 2007; 292(5): L1064 - L1072.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-K. Kim, S.-Y. Oh, S. G. Jeon, H.-W. Park, S.-Y. Lee, E.-Y. Chun, B. Bang, H.-S. Lee, M.-H. Oh, Y.-S. Kim, et al.
Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma
J. Immunol., April 15, 2007; 178(8): 5375 - 5382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. Matsubara, K. Takeda, T. Kodama, A. Joetham, N. Miyahara, T. Koya, C. H. Swasey, M. Okamoto, A. Dakhama, and E. W. Gelfand
IL-2 and IL-18 Attenuation of Airway Hyperresponsiveness Requires STAT4, IFN-{gamma}, and Natural Killer Cells
Am. J. Respir. Cell Mol. Biol., March 1, 2007; 36(3): 324 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Koya, K. Takeda, T. Kodama, N. Miyahara, S. Matsubara, A. Balhorn, A. Joetham, A. Dakhama, and E. W. Gelfand
RANTES (CCL5) Regulates Airway Responsiveness after Repeated Allergen Challenge
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 147 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Koch, M. Witzenrath, C. Reuter, M. Herma, H. Schutte, N. Suttorp, H. Collins, and S. H. E. Kaufmann
Role of Local Pulmonary IFN-{gamma} Expression in Murine Allergic Airway Inflammation
Am. J. Respir. Cell Mol. Biol., August 1, 2006; 35(2): 211 - 219.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
M. J. Holtzman, J. W. Tyner, E. Y. Kim, M. S. Lo, A. C. Patel, L. P. Shornick, E. Agapov, and Y. Zhang
Acute and Chronic Airway Responses to Viral Infection: Implications for Asthma and Chronic Obstructive Pulmonary Disease
Proceedings of the ATS, August 1, 2005; 2(2): 132 - 140.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S.-H. Cho, L. A. Stanciu, S. T. Holgate, and S. L. Johnston
Increased Interleukin-4, Interleukin-5, and Interferon-{gamma} in Airway CD4+ and CD8+ T Cells in Atopic Asthma
Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 224 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
N. M. Heller, S. Matsukura, S. N. Georas, M. R. Boothby, P. B. Rothman, C. Stellato, and R. P. Schleimer
Interferon-{gamma} Inhibits STAT6 Signal Transduction and Gene Expression in Human Airway Epithelial Cells
Am. J. Respir. Cell Mol. Biol., November 1, 2004; 31(5): 573 - 582.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Castro, S. R. Bloch, M. V. Jenkerson, S. DeMartino, D. L. Hamilos, R. B. Cochran, X. E. L. Zhang, H. Wang, J. P. Bradley, K. B. Schechtman, et al.
Asthma Exacerbations after Glucocorticoid Withdrawal Reflects T Cell Recruitment to the Airway
Am. J. Respir. Crit. Care Med., April 1, 2004; 169(7): 842 - 849.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Z.-H. Cui, A. Joetham, M. K. Aydintug, Y.-S. Hahn, W. K. Born, and E. W. Gelfand
Reversal of Allergic Airway Hyperreactivity after Long-term Allergen Challenge Depends on {gamma}{delta} T Cells
Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1324 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Takeda, N. Miyahara, Y.-H. Rha, C. Taube, E.-S. Yang, A. Joetham, T. Kodama, A. M. Balhorn, A. Dakhama, C. Duez, et al.
Surfactant Protein D Regulates Airway Function and Allergic Inflammation through Modulation of Macrophage Function
Am. J. Respir. Crit. Care Med., October 1, 2003; 168(7): 783 - 789.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sehra, G. Pynaert, K. Tournoy, A. Haegeman, P. Matthys, Y. Tagawa, R. Pauwels, and J. Grooten
Airway IgG Counteracts Specific and Bystander Allergen-Triggered Pulmonary Inflammation by a Mechanism Dependent on Fc{gamma}R and IFN-{gamma}
J. Immunol., August 15, 2003; 171(4): 2080 - 2089.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. L. Hardy, L. Kenins, A. C. Drew, J. M. Rolland, and R. E. O'Hehir
Characterization of a Mouse Model of Allergy to a Major Occupational Latex Glove Allergen Hev b 5
Am. J. Respir. Crit. Care Med., May 15, 2003; 167(10): 1393 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Schramm, U. Herz, J. Podlech, M. Protschka, S. Finotto, M. J. Reddehase, H. Kohler, P. R. Galle, A. W. Lohse, and M. Blessing
TGF-{beta} Regulates Airway Responses Via T Cells
J. Immunol., February 1, 2003; 170(3): 1313 - 1319.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Yoshida, R. Leigh, K. Matsumoto, J. Wattie, R. Ellis, P. M. O'Byrne, and M. D. Inman
Effect of Interferon-{gamma} on Allergic Airway Responses in Interferon-{gamma}-deficient Mice
Am. J. Respir. Crit. Care Med., August 15, 2002; 166(4): 451 - 456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. D. Medoff, A. Sauty, A. M. Tager, J. A. Maclean, R. N. Smith, A. Mathew, J. H. Dufour, and A. D. Luster
IFN-{gamma}-Inducible Protein 10 (CXCL10) Contributes to Airway Hyperreactivity and Airway Inflammation in a Mouse Model of Asthma
J. Immunol., May 15, 2002; 168(10): 5278 - 5286.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. O-Quan Shi, M. J. Fischer, G. T. De Sanctis, M. R. Schuyler, and Y. Tesfaigzi
IFN-{gamma}, But Not Fas, Mediates Reduction of Allergen-Induced Mucous Cell Metaplasia by Inducing Apoptosis
J. Immunol., May 1, 2002; 168(9): 4764 - 4771.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.C. Kips
Cytokines in asthma
Eur. Respir. J., July 2, 2001; 18(34_suppl): 24S - 33s.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
P.J. Barnes
Cytokine modulators as novel therapies for airway disease
Eur. Respir. J., July 2, 2001; 18(34_suppl): 67S - 77s.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
A. G.-H. Jember, R. Zuberi, F.-T. Liu, and M. Croft
Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor OX40
J. Exp. Med., February 5, 2001; 193(3): 387 - 392.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Ishimitsu, H. Nishimura, T. Yajima, T. Watase, H. Kawauchi, and Y. Yoshikai
Overexpression of IL-15 In Vivo Enhances Tc1 Response, Which Inhibits Allergic Inflammation in a Murine Model of Asthma
J. Immunol., February 1, 2001; 166(3): 1991 - 2001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
E. Hamelmann, K. Takeda, A. Haczku, G. Cieslewicz, L. Shultz, Q. Hamid, Z. Xing, J. Gauldie, and E. W. Gelfand
Interleukin (IL)-5 but Not Immunoglobulin E Reconstitutes Airway Inflammation and Airway Hyperresponsiveness in IL-4-Deficient Mice
Am. J. Respir. Cell Mol. Biol., September 1, 2000; 23(3): 327 - 334.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
E. M. Varga, P. Wachholz, K. T. Nouri-Aria, A. Verhoef, C. J. Corrigan, S. J. Till, and S. R. Durham
T Cells from Human Allergen-Induced Late Asthmatic Responses Express IL-12 Receptor {beta}2 Subunit mRNA and Respond to IL-12 In Vitro
J. Immunol., September 1, 2000; 165(5): 2877 - 2885.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. O. MAGNAN, L. G. MÉLY, C. A. CAMILLA, M. M. BADIER, F. A. MONTERO-JULIAN, C. M. GUILLOT, B. B. CASANO, S. J. PRATO, V. FERT, P. BONGRAND, et al.
Assessment of the Th1/Th2 Paradigm in Whole Blood in Atopy and Asthma . Increased IFN-gamma -producing CD8+ T Cells in Asthma
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 1790 - 1796.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Steinmüller, G. Franke-Ullmann, M.-L. Lohmann-Matthes, and A. Emmendörffer
Local Activation of Nonspecific Defense against a Respiratory Model Infection by Application of Interferon-gamma . Comparison between Rat Alveolar and Interstitial Lung Macrophages
Am. J. Respir. Cell Mol. Biol., April 1, 2000; 22(4): 481 - 490.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
L. C. von Hertzen and T. Haahtela
Could the Risk of Asthma and Atopy Be Reduced by a Vaccine That Induces a Strong T-helper Type 1 Response?
Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 139 - 142.
[Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. Castro, D. D. Chaplin, M. J. Walter, and M. J. Holtzman
Could Asthma Be Worsened by Stimulating the T-helper Type 1 Immune Response?
Am. J. Respir. Cell Mol. Biol., February 1, 2000; 22(2): 143 - 146.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. FUJIEDA, S. IHO, Y. KIMURA, H. SUNAGA, H. IGAWA, C. SUGIMOTO, S. YAMAMOTO, and H. SAITO
DNA from Mycobacterium bovis Bacillus Calmette-Guerin (MY-1) Inhibits Immunoglobulin E Production by Human Lymphocytes
Am. J. Respir. Crit. Care Med., December 1, 1999; 160(6): 2056 - 2061.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. R. Stämpfli, G. Scott Neigh, R. E. Wiley, M. Cwiartka, S. A. Ritz, M. M. Hitt, Z. Xing, and M. Jordana
Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway
Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 317 - 326.
[Abstract] [Full Text]

Home page
 ThoraxHome page
K F Chung and P J Barnes
Cytokines in asthma
Thorax, September 1, 1999; 54(9): 825 - 857.
[Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
A. HACZKU, K. TAKEDA, I. REDAI, E. HAMELMANN, G. CIESLEWICZ, A. JOETHAM, J. LOADER, J. J. LEE, C. IRVIN, and E. W. GELFAND
Anti-CD86 (B7.2) Treatment Abolishes Allergic Airway Hyperresponsiveness in Mice
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1638 - 1643.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. A. Randolph, C. J. L. Carruthers, S. J. Szabo, K. M. Murphy, and D. D. Chaplin
Modulation of Airway Inflammation by Passive Transfer of Allergen-Specific Th1 and Th2 Cells in a Mouse Model of Asthma
J. Immunol., February 15, 1999; 162(4): 2375 - 2383.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. J. Barnes, K. F. Chung, and C. P. Page
Inflammatory Mediators of Asthma: An Update
Pharmacol. Rev., December 1, 1998; 50(4): 515 - 596.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. L. Hofstra, I. Van Ark, G. Hofman, F. P. Nijkamp, P. M. Jardieu, and A. J. M. Van Oosterhout
Differential Effects of Endogenous and Exogenous Interferon-gamma on Immunoglobulin E, Cellular Infiltration, and Airway Responsiveness in a Murine Model of Allergic Asthma
Am. J. Respir. Cell Mol. Biol., November 1, 1998; 19(5): 826 - 835.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
C. L. Hofstra, I. Van Ark, G. Hofman, M. Kool, F. P. Nijkamp, and A. J. M. Van Oosterhout
Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 Is Associated with Inhibition of Antigen-Induced Airway Hyperresponsiveness, Eosinophilia, and Serum IgE Levels
J. Immunol., November 1, 1998; 161(9): 5054 - 5060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. J. M. Van Oosterhout, B. Van Esch, G. Hofman, C. L. Hofstra, I. Van Ark, F. P. Nijkamp, M. L. Kapsenberg, H. F. J. Savelkoul, and F. R. Weller
Allergen Immunotherapy Inhibits Airway Eosinophilia and Hyperresponsiveness Associated with Decreased IL-4 Production by Lymphocytes in a Murine Model of Allergic Asthma
Am. J. Respir. Cell Mol. Biol., October 1, 1998; 19(4): 622 - 628.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
D. I. Blyth, M. S. Pedrick, T. J. Savage, H. Bright, J. E. Beesley, and S. Sanjar
Induction, Duration, and Resolution of Airway Goblet Cell Hyperplasia in a Murine Model of Atopic Asthma: Effect of Concurrent Infection with Respiratory Syncytial Virus and Response to Dexamethasone
Am. J. Respir. Cell Mol. Biol., July 1, 1998; 19(1): 38 - 54.
[Abstract] [Full Text]

Home page
 J. Exp. Med.Home page
B. W.P. Seymour, L. J. Gershwin, and R. L. Coffman
Aerosol-induced Immunoglobulin (Ig)-E Unresponsiveness to Ovalbumin Does Not Require CD8+ or T Cell Receptor (TCR)-gamma /delta + T Cells or Interferon (IFN)-gamma in a Murine Model of Allergen Sensitization
J. Exp. Med., March 2, 1998; 187(5): 721 - 731.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
K. J. Erb, J. W. Holloway, A. Sobeck, H. Moll, and G. Le Gros
Infection of Mice with Mycobacterium bovis-Bacillus Calmette-Guerin (BCG) Suppresses Allergen-induced Airway Eosinophilia
J. Exp. Med., February 16, 1998; 187(4): 561 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. A. PAUWELS, G. J. BRUSSELLE, and J. C. KIPS
Cytokine Manipulation in Animal Models of Asthma
Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): S78 - S81.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. B. VARGAFTIG
Modifications of Experimental Bronchopulmonary Hyperresponsiveness
Am. J. Respir. Crit. Care Med., October 1, 1997; 156(4): S97 - S102.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.