| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 4 1337-1341, Copyright © 1996 by American Association of Immunologists
CUTTING EDGE |
N Van Houten and SF Blake
Department of Internal Medicine, Galveston 77555-0366, USA. nvanhout@beach.utmb.edu
T cell tolerance induced by oral administration of Ag may be the result of either deletion or functional inactivation of Ag-specific T cells. OVA p(323-339)-specific TCR transgenic (Tg+) lymphocytes were transplanted into BALB/c recipients. Chimeric mice were fed OVA and subsequently challenged with the peptide in CFA. Tolerance was then assessed by measurement of lymph node (LN) cell proliferation in response to the peptide, and deletion was assessed by measuring the frequency Tg+ T cells by flow cytometry. Lymphocytes from chimeric mice fed OVA showed a dose-dependent decline in their proliferative response to the peptide in vitro, compared with immunized control mice that were not fed OVA. Calculation of proliferative potential per Tg+ cell demonstrates that nonresponsiveness due to feeding Ag results in the induction of anergy in the LN. In addition, analysis of intestinal intraepithelial lymphocytes following feeding of OVA did not show evidence of trafficking of LN T cells to the small intestine intraepithelial nor lamina propria compartments.
This article has been cited by other articles:
|
|
 |
|
  S. Sakai, H. Akiyama, Y. Sato, Y. Yoshioka, R. J. Linhardt, Y. Goda, T. Maitani, and T. Toida Chondroitin Sulfate Intake Inhibits the IgE-mediated Allergic Response by Down-regulating Th2 Responses in Mice J. Biol. Chem., July 21, 2006; 281(29): 19872 - 19880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Macpherson and K. Smith Mesenteric lymph nodes at the center of immune anatomy J. Exp. Med., March 20, 2006; 203(3): 497 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Alvarez, F. K. Swirski, T.-C. Yang, R. Fattouh, K. Croitoru, J. L. Bramson, M. R. Stampfli, and M. Jordana Inhalation Tolerance Is Induced Selectively in Thoracic Lymph Nodes but Executed Pervasively at Distant Mucosal and Nonmucosal Tissues J. Immunol., February 15, 2006; 176(4): 2568 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ise, K. Nakamura, N. Shimizu, H. Goto, K. Fujimoto, S. Kaminogawa, and S. Hachimura Orally Tolerized T Cells Can Form Conjugates with APCs but Are Defective in Immunological Synapse Formation J. Immunol., July 15, 2005; 175(2): 829 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Parameswaran, D. J. Samuvel, R. Kumar, S. Thatai, V. Bal, S. Rath, and A. George Oral Tolerance in T Cells Is Accompanied by Induction of Effector Function in Lymphoid Organs after Systemic Immunization Infect. Immun., July 1, 2004; 72(7): 3803 - 3811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kaji, S. Hachimura, W. Ise, and S. Kaminogawa Proteome Analysis Reveals Caspase Activation in Hyporesponsive CD4 T Lymphocytes Induced in Vivo by the Oral Administration of Antigen J. Biol. Chem., July 18, 2003; 278(30): 27836 - 27843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Asai, S. Hachimura, M. Kimura, T. Toraya, M. Yamashita, T. Nakayama, and S. Kaminogawa T Cell Hyporesponsiveness Induced by Oral Administration of Ovalbumin Is Associated with Impaired NFAT Nuclear Translocation and p27kip1 Degradation J. Immunol., November 1, 2002; 169(9): 4723 - 4731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Williamson, J. M. Bilsborough, and J. L. Viney Regulation of Mucosal Dendritic Cell Function by Receptor Activator of NF-{kappa}B (RANK)/RANK Ligand Interactions: Impact on Tolerance Induction J. Immunol., October 1, 2002; 169(7): 3606 - 3612. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. V. Collins, K. Eriksson, R. G. Ulrich, and A. Tarkowski Mucosal Tolerance to a Bacterial Superantigen Indicates a Novel Pathway To Prevent Toxic Shock Infect. Immun., May 1, 2002; 70(5): 2282 - 2287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Maron, A. J. Slavin, E. Hoffmann, Y. Komagata, and H. L. Weiner Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines Int. Immunol., February 1, 2002; 14(2): 131 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Meyer, J. Benson, F. Song, N. Javed, I. E. Gienapp, J. Goverman, T. A. Brabb, L. Hood, and C. C. Whitacre Rapid Depletion of Peripheral Antigen-Specific T Cells in TCR-Transgenic Mice After Oral Administration of Myelin Basic Protein J. Immunol., May 1, 2001; 166(9): 5773 - 5781. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. SMITH, A. D. EATON, L. M. FINLAYSON, and P. GARSIDE Oral Tolerance Am. J. Respir. Crit. Care Med., October 1, 2000; 162(4): S175 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Egan, C. Yorkey, R. Black, W. K. Loh, J. L. Stevens, E. Storozynsky, E. M. Lord, J. G. Frelinger, and J. G. Woodward In Vivo Behavior of Peptide-Specific T Cells During Mucosal Tolerance Induction: Antigen Introduced Through the Mucosa of the Conjunctiva Elicits Prolonged Antigen-Specific T Cell Priming Followed by Anergy J. Immunol., May 1, 2000; 164(9): 4543 - 4550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Desvignes, N. Etchart, J. Kehren, I. Akiba, J.-F. Nicolas, and D. Kaiserlian Oral Administration of Hapten Inhibits In Vivo Induction of Specific Cytotoxic CD8+ T Cells Mediating Tissue Inflammation: A Role for Regulatory CD4+ T Cells J. Immunol., March 1, 2000; 164(5): 2515 - 2522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fujihashi, T. Dohi, M.-N. Kweon, J. R. Mcghee, T. Koga, M. D. Cooper, S. Tonegawa, and H. Kiyono {gamma}{delta}T cells regulate mucosally induced tolerance in a dose-dependent fashion Int. Immunol., December 1, 1999; 11(12): 1907 - 1916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Garg, V. Bal, S. Rath, and A. George Effect of Multiple Antigenic Exposures in the Gut on Oral Tolerance and Induction of Antibacterial Systemic Immunity Infect. Immun., November 1, 1999; 67(11): 5917 - 5924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McI. Mowat, M. Steel, A. J. Leishman, and P. Garside Normal Induction of Oral Tolerance in the Absence of a Functional IL-12-Dependent IFN-{gamma} Signaling Pathway J. Immunol., November 1, 1999; 163(9): 4728 - 4736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Wang, Y. Wang-Zhu, C. R. Gabaglia, K. Kimachi, and H. M. Grey The Stimulation of Low-Affinity, Nontolerized Clones by Heteroclitic Antigen Analogues Causes the Breaking of Tolerance Established to an Immunodominant T Cell Epitope J. Exp. Med., October 4, 1999; 190(7): 983 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Williamson, G. M. Westrich, and J. L. Viney Modulating Dendritic Cells to Optimize Mucosal Immunization Protocols J. Immunol., October 1, 1999; 163(7): 3668 - 3675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sun, B. Dirden-Kramer, K. Ito, P. B. Ernst, and N. Van Houten Antigen-Specific T Cell Activation and Proliferation During Oral Tolerance Induction J. Immunol., May 15, 1999; 162(10): 5868 - 5875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Benson, S. S. Stuckman, K. L. Cox, R. M. Wardrop, I. E. Gienapp, A. H. Cross, J. L. Trotter, and C. C. Whitacre Oral Administration of Myelin Basic Protein Is Superior to Myelin in Suppressing Established Relapsing Experimental Autoimmune Encephalomyelitis J. Immunol., May 15, 1999; 162(10): 6247 - 6254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Shi, M. J. Grusby, and C. Nagler-Anderson Orally Induced Peripheral Nonresponsiveness Is Maintained in the Absence of Functional Th1 or Th2 Cells J. Immunol., May 1, 1999; 162(9): 5143 - 5148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P GARSIDE, A M. MOWAT, and A KHORUTS Oral tolerance in disease Gut, January 1, 1999; 44(1): 137 - 142. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Viney, A. M. Mowat, J. M. O'Malley, E. Williamson, and N. A. Fanger Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance J. Immunol., June 15, 1998; 160(12): 5815 - 5825. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
