| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 3 1096-1106, Copyright © 1996 by American Association of Immunologists
ARTICLES |
DA Steeber, NE Green, S Sato and TF Tedder
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Lymphocyte trafficking across high endothelial venules (HEV) of peripheral lymph nodes (PLN) is dependent upon lymphocyte expression of L-selectin. Mice that lack this adhesion molecule provide an opportunity to determine the long-term role of L-selectin-mediated migration in the maintenance of leukocyte subpopulations. HEV in L- selectin-deficient mice were phenotypically, morphologically, and functionally comparable with wild-type mice, although there was a 70 to 90% reduction in the number of lymphocytes within PLN. These lymphocytes most likely entered PLN through the afferent lymphatics, since they did not migrate into PLN of normal mice during short-term homing experiments. The impaired trafficking of lymphocytes across PLN- HEV resulted in the accumulation of memory (CD18highCD44high) lymphocytes within PLN, and also altered the distribution of lymphocyte subpopulations within other tissues. Specifically, a 30 to 55% increase in splenic cellularity occurred due to increases in both naive and memory lymphocytes. Circulating lymphocyte numbers or subpopulations were not altered in young L-selectin-deficient mice, but circulating monocyte numbers were increased nearly threefold. In contrast, older L- selectin-deficient mice had disproportionate increases of both naive and memory CD4+ T cells present within spleen and blood. These results and the finding that memory lymphocytes in wild-type mice expressed L- selectin demonstrate a requirement for L-selectin in the regulation of memory lymphocyte migration. Therefore, L-selectin-dependent pathways of lymphocyte migration are important for the normal migration of both naive and memory lymphocytes.
This article has been cited by other articles:
|
|
 |
|
  H. Xu, A. Manivannan, I. Crane, R. Dawson, and J. Liversidge Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation Blood, August 15, 2008; 112(4): 1166 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Pascual, X. Wang, I. Kochetkova, G. Callis, and C. Riccardi The Absence of Lymphoid CD8+ Dendritic Cell Maturation in L-Selectin-/- Respiratory Compartment Attenuates Antiviral Immunity J. Immunol., July 15, 2008; 181(2): 1345 - 1356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Lee, J. B. Schultz, P. A. Knauf, and M. R. King Mechanical Shedding of L-selectin from the Neutrophil Surface during Rolling on Sialyl Lewis x under Flow J. Biol. Chem., February 16, 2007; 282(7): 4812 - 4820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Venturi, R. M. Conway, D. A. Steeber, and T. F. Tedder CD25+CD4+ Regulatory T Cell Migration Requires L-Selectin Expression: L-Selectin Transcriptional Regulation Balances Constitutive Receptor Turnover J. Immunol., January 1, 2007; 178(1): 291 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Mangan, D. O'Quinn, L. Harrington, C. S. Bonder, P. Kubes, D. F. Kucik, D. C. Bullard, and C. T. Weaver Both Th1 and Th2 Cells Require P-Selectin Glycoprotein Ligand-1 for Optimal Rolling on Inflamed Endothelium Am. J. Pathol., December 1, 2005; 167(6): 1661 - 1675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Unsoeld, D. Voehringer, S. Krautwald, and H. Pircher Constitutive Expression of CCR7 Directs Effector CD8 T Cells into the Splenic White Pulp and Impairs Functional Activity J. Immunol., September 1, 2004; 173(5): 3013 - 3019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Mora, I. S. Grewal, F. S. Wong, and R. A. Flavell Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice Int. Immunol., February 1, 2004; 16(2): 257 - 264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Johansson-Lindbom, M. Svensson, M.-A. Wurbel, B. Malissen, G. Marquez, and W. Agace Selective Generation of Gut Tropic T Cells in Gut-associated Lymphoid Tissue (GALT): Requirement for GALT Dendritic Cells and Adjuvant J. Exp. Med., September 15, 2003; 198(6): 963 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Hengel, V. Thaker, M. V. Pavlick, J. A. Metcalf, G. Dennis Jr., J. Yang, R. A. Lempicki, I. Sereti, and H. C. Lane Cutting Edge: L-Selectin (CD62L) Expression Distinguishes Small Resting Memory CD4+ T Cells That Preferentially Respond to Recall Antigen J. Immunol., January 1, 2003; 170(1): 28 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Csencsits and D. W. Pascual Absence of L-Selectin Delays Mucosal B Cell Responses in Nonintestinal Effector Tissues J. Immunol., November 15, 2002; 169(10): 5649 - 5659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kadono, G. M. Venturi, D. A. Steeber, and T. F. Tedder Leukocyte Rolling Velocities and Migration Are Optimized by Cooperative L-Selectin and Intercellular Adhesion Molecule-1 Functions J. Immunol., October 15, 2002; 169(8): 4542 - 4550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Roy, C. H. Kim, and E. C. Butcher Cytokine Control of Memory B Cell Homing Machinery J. Immunol., August 15, 2002; 169(4): 1676 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. Friedline, C. P. Wong, D. A. Steeber, T. F. Tedder, and R. Tisch L-Selectin Is Not Required for T Cell-Mediated Autoimmune Diabetes J. Immunol., March 15, 2002; 168(6): 2659 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pedron, R. Girard, and R. Chaby Down-Modulation of L-Selectin by Lipopolysaccharide Is Not Required for Lipopolysaccharide-Induced Expression of CD14 in Mouse Bone Marrow Granulocytes Infect. Immun., July 1, 2001; 69(7): 4287 - 4294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Leid, D. A. Steeber, T. F. Tedder, and M. A. Jutila Antibody Binding to a Conformation-Dependent Epitope Induces L-Selectin Association with the Detergent-Resistant Cytoskeleton J. Immunol., April 15, 2001; 166(8): 4899 - 4907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mori, H. Nakano, K. Aritomi, C.-R. Wang, M. D. Gunn, and T. Kakiuchi Mice Lacking Expression of the Chemokines CCL21-Ser and CCL19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses J. Exp. Med., January 8, 2001; 193(2): 207 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Mattila, A. Nykanen, M. Eloranta, and J. Tarkkanen Adenoids provide a microenvironment for the generation of CD4+, CD45RO+, L-selectin-, CXCR4+, CCR5+ T lymphocytes, a lymphocyte phenotype found in the middle ear effusion Int. Immunol., September 1, 2000; 12(9): 1235 - 1243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. U. Goebel and P. J. Mills Acute Psychological Stress and Exercise and Changes in Peripheral Leukocyte Adhesion Molecule Expression and Density Psychosom Med, September 1, 2000; 62(5): 664 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Bennett, B. S. Edwards, L. A. Sklar, and S. Rogelj Sulfhydryl Regulation of L-Selectin Shedding: Phenylarsine Oxide Promotes Activation-Independent L-Selectin Shedding from Leukocytes J. Immunol., April 15, 2000; 164(8): 4120 - 4129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yang, T. Hirata, K. Croce, G. Merrill-Skoloff, B. Tchernychev, E. Williams, R. Flaumenhaft, B. C. Furie, and B. Furie Targeted Gene Disruption Demonstrates That P-Selectin Glycoprotein Ligand 1 (PSGL-1) Is Required for P-Selectin-mediated but Not E-Selectin-mediated Neutrophil Rolling and Migration J. Exp. Med., December 20, 1999; 190(12): 1769 - 1782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ahmadzadeh, S. F. Hussain, and D. L. Farber Effector CD4 T Cells Are Biochemically Distinct from the Memory Subset: Evidence for Long-Term Persistence of Effectors In Vivo J. Immunol., September 15, 1999; 163(6): 3053 - 3063. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Marschner, B. A. Freiberg, A. Kupfer, T. Hunig, and T. H. Finkel Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectin PNAS, August 17, 1999; 96(17): 9763 - 9768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kantele, J. Zivny, M. Hakkinen, C. O. Elson, and J. Mestecky Differential Homing Commitments of Antigen-Specific T Cells After Oral or Parenteral Immunization in Humans J. Immunol., May 1, 1999; 162(9): 5173 - 5177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Steeber, M. L. K. Tang, X.-Q. Zhang, W. Muller, N. Wagner, and T. F. Tedder Efficient Lymphocyte Migration Across High Endothelial Venules of Mouse Peyer's Patches Requires Overlapping Expression of L-Selectin and {beta}7 Integrin J. Immunol., December 15, 1998; 161(12): 6638 - 6647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tangemann, M. D. Gunn, P. Giblin, and S. D. Rosen A High Endothelial Cell-Derived Chemokine Induces Rapid, Efficient, and Subset-Selective Arrest of Rolling T Lymphocytes on a Reconstituted Endothelial Substrate J. Immunol., December 1, 1998; 161(11): 6330 - 6337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Kunkel, C. L. Ramos, D. A. Steeber, W. Muller, N. Wagner, T. F. Tedder, and K. Ley The Roles of L-Selectin, {beta}7 Integrins, and P-Selectin in Leukocyte Rolling and Adhesion in High Endothelial Venules of Peyer's Patches J. Immunol., September 1, 1998; 161(5): 2449 - 2456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Steeber, M. A. Campbell, A. Basit, K. Ley, and T. F. Tedder Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression PNAS, June 23, 1998; 95(13): 7562 - 7567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chiba, Y. Yanagawa, Y. Masubuchi, H. Kataoka, T. Kawaguchi, M. Ohtsuki, and Y. Hoshino FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing J. Immunol., May 15, 1998; 160(10): 5037 - 5044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. K. Tang, D. A. Steeber, X.-Q. Zhang, and T. F. Tedder Intrinsic Differences in L-Selectin Expression Levels Affect T and B Lymphocyte Subset-Specific Recirculation Pathways J. Immunol., May 15, 1998; 160(10): 5113 - 5121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Salmi, S. Tohka, E. L. Berg, E. C. Butcher, and S. Jalkanen Vascular Adhesion Protein 1 (VAP-1) Mediates Lymphocyte Subtype-specific, Selectin-independent Recognition of Vascular Endothelium in Human Lymph Nodes J. Exp. Med., August 18, 1997; 186(4): 589 - 600. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
