The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lentz, V. M.
Right arrow Articles by Hayes, C. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lentz, V. M.
Right arrow Articles by Hayes, C. E.

The Journal of Immunology, Vol 157, Issue 2 598-606, Copyright © 1996 by American Association of Immunologists

ARTICLES

Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse

VM Lentz, MP Cancro, FE Nashold and CE Hayes
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

The A/WySnJ mouse provides a genetic model for studying new B cell selection into the stable peripheral B cell pool. Unlike the related A/J strain, the A/WySnJ has a single, autosomal codominant gene defect, Bcmd, resulting in a profound peripheral B cell deficiency. Here, continuous in vivo bromodeoxyuridine labeling and immunofluorescence analysis showed normal bone marrow B cell genesis but excessive B cell loss from the marrow and each peripheral pool in A/WySnJ. The A/WySnJ immature B220low/HSAhigh splenic B cell pool was 79% smaller, had a 69% slower renewal rate, and its cells had a 29% shorter average half-life than A/J. The A/WySnJ mature B220high/HSAlow splenic B cell pool was 92% smaller, had an 83% slower renewal rate, and its cells had a 56% shorter average half-life. In reciprocal chimeras, the A/WySnJ marrow failed to repopulate the peripheral B cell pool in A/J mice, whereas the A/J marrow fully reconstituted the A/WySnJ mice. Histochemistry revealed disordered splenic architecture in A/WySnJ, with few primary lymphoid follicles and a second abnormal phenotype, mastocytosis. There was no common genetic basis for B cell deficiency and mastocytosis in the F2 progeny of an (A/WySnJ x CAST/Ei)F1 intercross. We conclude that Bcmd is expressed in bone marrow cells, most likely B cells, where it hinders short-lived B cell maturation to a long-lived phenotype with the potential to form memory B cells.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
L. S. Treml, G. Carlesso, K. L. Hoek, J. E. Stadanlick, T. Kambayashi, R. J. Bram, M. P. Cancro, and W. N. Khan
TLR Stimulation Modifies BLyS Receptor Expression in Follicular and Marginal Zone B Cells
J. Immunol., June 15, 2007; 178(12): 7531 - 7539.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Kato, A. Q. Truong-Tran, A. L. Scott, K. Matsumoto, and R. P. Schleimer
Airway Epithelial Cells Produce B Cell-Activating Factor of TNF Family by an IFN-beta-Dependent Mechanism
J. Immunol., November 15, 2006; 177(10): 7164 - 7172.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. P. Miller, J. E. Stadanlick, and M. P. Cancro
Space, Selection, and Surveillance: Setting Boundaries with BLyS.
J. Immunol., June 1, 2006; 176(11): 6405 - 6410.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Bischof, S. F. Elsawa, G. Mantchev, J. Yoon, G. E. Michels, A. Nilson, S. L. Sutor, J. L. Platt, S. M. Ansell, G. von Bulow, et al.
Selective activation of TACI by syndecan-2
Blood, April 15, 2006; 107(8): 3235 - 3242.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. F. Elsawa, A. J. Novak, D. M. Grote, S. C. Ziesmer, T. E. Witzig, R. A. Kyle, S. R. Dillon, B. Harder, J. A. Gross, and S. M. Ansell
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia
Blood, April 1, 2006; 107(7): 2882 - 2888.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Stoel, H.-Q. Jiang, C. C. van Diemen, J. C. A. M. Bun, P. M. Dammers, M. C. Thurnheer, F. G. M. Kroese, J. J. Cebra, and N. A. Bos
Restricted IgA Repertoire in Both B-1 and B-2 Cell-Derived Gut Plasmablasts
J. Immunol., January 15, 2005; 174(2): 1046 - 1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Z. S. M. Rahman and T. Manser
B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers
J. Immunol., November 15, 2004; 173(10): 6179 - 6188.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. E. Labrie III, A. P. Sah, D. M. Allman, M. P. Cancro, and R. M. Gerstein
Bone Marrow Microenvironmental Changes Underlie Reduced RAG-mediated Recombination and B Cell Generation in Aged Mice
J. Exp. Med., August 16, 2004; 200(4): 411 - 423.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Sasaki, S. Casola, J. L. Kutok, K. Rajewsky, and M. Schmidt-Supprian
TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology
J. Immunol., August 15, 2004; 173(4): 2245 - 2252.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Shulga-Morskaya, M. Dobles, M. E. Walsh, L. G. Ng, F. MacKay, S. P. Rao, S. L. Kalled, and M. L. Scott
B Cell-Activating Factor Belonging to the TNF Family Acts through Separate Receptors to Support B Cell Survival and T Cell-Independent Antibody Formation
J. Immunol., August 15, 2004; 173(4): 2331 - 2341.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. P. Cancro and J. F. Kearney
B Cell Positive Selection: Road Map to the Primary Repertoire?
J. Immunol., July 1, 2004; 173(1): 15 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
B. P. O'Connor, V. S. Raman, L. D. Erickson, W. J. Cook, L. K. Weaver, C. Ahonen, L.-L. Lin, G. T. Mantchev, R. J. Bram, and R. J. Noelle
BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells
J. Exp. Med., January 5, 2004; 199(1): 91 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F Melchers
Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease
Ann Rheum Dis, November 1, 2003; 62(90002): ii25 - 27.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
Z. SM. Rahman, S. P. Rao, S. L. Kalled, and T. Manser
Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling-Deficient Mice
J. Exp. Med., October 20, 2003; 198(8): 1157 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. H. Smith and M. P. Cancro
Cutting Edge: B Cell Receptor Signals Regulate BLyS Receptor Levels in Mature B Cells and Their Immediate Progenitors
J. Immunol., June 15, 2003; 170(12): 5820 - 5823.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. J. Amanna, J. P. Dingwall, and C. E. Hayes
Enforced bcl-xL Gene Expression Restored Splenic B Lymphocyte Development in BAFF-R Mutant Mice
J. Immunol., May 1, 2003; 170(9): 4593 - 4600.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. L. Hsu, S. M. Harless, R. C. Lindsley, D. M. Hilbert, and M. P. Cancro
Cutting Edge: BLyS Enables Survival of Transitional and Mature B Cells Through Distinct Mediators
J. Immunol., June 15, 2002; 168(12): 5993 - 5996.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. P. Cancro, A. P. Sah, S. L. Levy, D. M. Allman, M. R. Schmidt, and R. T. Woodland
xid mice reveal the interplay of homeostasis and Bruton's tyrosine kinase-mediated selection at multiple stages of B cell development
Int. Immunol., December 1, 2001; 13(12): 1501 - 1514.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
I. J. Amanna, K. Clise-Dwyer, F. E. Nashold, K. A. Hoag, and C. E. Hayes
Cutting Edge: A/WySnJ Transitional B Cells Overexpress the Chromosome 15 Proapoptotic Blk Gene and Succumb to Premature Apoptosis
J. Immunol., December 1, 2001; 167(11): 6069 - 6072.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
V. M. Lentz and T. Manser
Self-limiting systemic autoimmune disease during reconstitution of T cell-deficient mice with syngeneic T cells: support for a multifaceted role of T cells in the maintenance of peripheral B cell tolerance
Int. Immunol., November 1, 2000; 12(11): 1483 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
K. A. Vora, K. M. Tumas-Brundage, V. M. Lentz, A. Cranston, R. Fishel, and T. Manser
Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice
J. Exp. Med., February 1, 1999; 189(3): 471 - 482.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
F. Agenes and A. A. Freitas
Transfer of Small Resting B Cells into Immunodeficient Hosts Results in the Selection of a Self-renewing Activated B Cell Population
J. Exp. Med., January 18, 1999; 189(2): 319 - 330.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. M. Lentz, C. E. Hayes, and M. P. Cancro
Bcmd Decreases the Life Span of B-2 But Not B-1 Cells in A/WySnJ Mice
J. Immunol., April 15, 1998; 160(8): 3743 - 3747.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. M. Tomayko and M. P. Cancro
Long-Lived B Cells Are Distinguished by Elevated Expression of A1
J. Immunol., January 1, 1998; 160(1): 107 - 111.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. Schiemann, J. L. Gommerman, K. Vora, T. G. Cachero, S. Shulga-Morskaya, M. Dobles, E. Frew, and M. L. Scott
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Science, September 14, 2001; 293(5537): 2111 - 2114.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. S. Thompson, S. A. Bixler, F. Qian, K. Vora, M. L. Scott, T. G. Cachero, C. Hession, P. Schneider, I. D. Sizing, C. Mullen, et al.
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Science, September 14, 2001; 293(5537): 2108 - 2111.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.