The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huang, M.
Right arrow Articles by Dubinett, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huang, M.
Right arrow Articles by Dubinett, S. M.

The Journal of Immunology, Vol 157, Issue 12 5512-5520, Copyright © 1996 by American Association of Immunologists

ARTICLES

Non-small cell lung cancer-derived soluble mediators and prostaglandin E2 enhance peripheral blood lymphocyte IL-10 transcription and protein production

M Huang, S Sharma, JT Mao and SM Dubinett
Department of Medicine, Johnson Comprehensive Cancer Center, University of California-Los Angeles School of Medicine, 90073, USA.

Studies suggest that IL-10 may contribute to tumor-associated immunosuppression. In the current study we evaluated the capacity of human non-small cell lung cancer (NSCLC) cell lines to induce PBL IL-10 production. We observed a 10- to 100-fold increase in human PBL IL-10 production following exposure to NSCLC cell supernatants. The tumor- induced increase in PBL IL-10 production was partially blocked by pretreatment of the tumors with the PG inhibitor indomethacin. NSCLC lines were found to constitutively produce PGE2. Exogenous PGE2 also induced PBL IL-10 production in a dose- and time-dependent manner. Both PGE2 and NSCLC supernatant-induced PBL IL-10 production were due to an increase in the IL-10 mRNA transcriptional rate. To evaluate the significance of tumor-induced lymphocyte IL-10 production, the capacity of PBL to produce IFN-gamma during culture in tumor supernatants was assessed in the presence of specific anti-IL-10 mAb. We found enhanced PBL IFN-gamma production following anti-IL-10 treatment. These in vitro studies imply that NSCLC-induced PBL IL-10 production may serve to shift the Th1/Th2 cytokine axis at the tumor site and thus inhibit cell- mediated anti-tumor immune responses. These findings identify a mechanism by which lung cancer cells may escape host immune surveillance. We conclude that NSCLC-derived soluble mediators, including PGs, may play an immunoregulatory role through induction of lymphocyte IL-10 production.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M.-R. Pan, M.-F. Hou, H.-C. Chang, and W.-C. Hung
Cyclooxygenase-2 Up-regulates CCR7 via EP2/EP4 Receptor Signaling Pathways to Enhance Lymphatic Invasion of Breast Cancer Cells
J. Biol. Chem., April 25, 2008; 283(17): 11155 - 11163.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Arimilli, E. M. Palmer, and M. A. Alexander-Miller
Loss of function in virus-specific lung effector T cells is independent of infection
J. Leukoc. Biol., March 1, 2008; 83(3): 564 - 574.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. W. Rohrer, A. L. Barsoum, and J. H. Coggin Jr.
Identification of Oncofetal Antigen/Immature Laminin Receptor Protein Epitopes That Activate BALB/c Mouse OFA/iLRP-Specific Effector and Regulatory T Cell Clones.
J. Immunol., March 1, 2006; 176(5): 2844 - 2856.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Baratelli, Y. Lin, L. Zhu, S.-C. Yang, N. Heuze-Vourc'h, G. Zeng, K. Reckamp, M. Dohadwala, S. Sharma, and S. M. Dubinett
Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells
J. Immunol., August 1, 2005; 175(3): 1483 - 1490.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Krysan, K. L. Reckamp, H. Dalwadi, S. Sharma, E. Rozengurt, M. Dohadwala, and S. M. Dubinett
Prostaglandin E2 Activates Mitogen-Activated Protein Kinase/Erk Pathway Signaling and Cell Proliferation in Non-Small Cell Lung Cancer Cells in an Epidermal Growth Factor Receptor-Independent Manner
Cancer Res., July 15, 2005; 65(14): 6275 - 6281.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sharma, L. Zhu, S. C. Yang, L. Zhang, J. Lin, S. Hillinger, B. Gardner, K. Reckamp, R. M. Strieter, M. Huang, et al.
Cyclooxygenase 2 Inhibition Promotes IFN-{gamma}-Dependent Enhancement of Antitumor Responses
J. Immunol., July 15, 2005; 175(2): 813 - 819.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
L. D. Dwyer-Nield, M. C. Srebernak, B. S. Barrett, J. Ahn, P. Cosper, A. M. Meyer, L. R. Kisley, A. K. Bauer, D. C. Thompson, and A. M. Malkinson
Cytokines differentially regulate the synthesis of prostanoid and nitric oxide mediators in tumorigenic versus non-tumorigenic mouse lung epithelial cell lines
Carcinogenesis, July 1, 2005; 26(7): 1196 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Sharma, S.-C. Yang, L. Zhu, K. Reckamp, B. Gardner, F. Baratelli, M. Huang, R. K. Batra, and S. M. Dubinett
Tumor Cyclooxygenase-2/Prostaglandin E2-Dependent Promotion of FOXP3 Expression and CD4+CD25+ T Regulatory Cell Activities in Lung Cancer
Cancer Res., June 15, 2005; 65(12): 5211 - 5220.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Lu, J.-C. Soria, X. Tang, X.-C. Xu, L. Wang, L. Mao, R. Lotan, B. Kemp, B. N. Bekele, L. Feng, et al.
Prognostic Factors in Resected Stage I Non-Small-Cell Lung Cancer: A Multivariate Analysis of Six Molecular Markers
J. Clin. Oncol., November 15, 2004; 22(22): 4575 - 4583.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. E. Baratelli, N. Heuze-Vourc'h, K. Krysan, M. Dohadwala, K. Riedl, S. Sharma, and S. M. Dubinett
Prostaglandin E2-Dependent Enhancement of Tissue Inhibitors of Metalloproteinases-1 Production Limits Dendritic Cell Migration through Extracellular Matrix
J. Immunol., November 1, 2004; 173(9): 5458 - 5466.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Pold, K. Krysan, A. Pold, M. Dohadwala, N. Heuze-Vourc'h, J. T. Mao, K. L. Riedl, S. Sharma, and S. M. Dubinett
Cyclooxygenase-2 Modulates the Insulin-Like Growth Factor Axis in Non-Small-Cell Lung Cancer
Cancer Res., September 15, 2004; 64(18): 6549 - 6555.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Pold, L. X. Zhu, S. Sharma, M. D. Burdick, Y. Lin, P. P. N. Lee, A. Pold, J. Luo, K. Krysan, M. Dohadwala, et al.
Cyclooxygenase-2-Dependent Expression of Angiogenic CXC Chemokines ENA-78/CXC Ligand (CXCL) 5 and Interleukin-8/CXCL8 in Human Non-Small Cell Lung Cancer
Cancer Res., March 1, 2004; 64(5): 1853 - 1860.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
J. T. Mao, M. D. Roth, K. J. Serio, F. Baratelli, L. Zhu, E. C. Holmes, R. M. Strieter, and S. M. Dubinett
Celecoxib Modulates the Capacity for Prostaglandin E2 and Interleukin-10 Production in Alveolar Macrophages from Active Smokers
Clin. Cancer Res., December 1, 2003; 9(16): 5835 - 5841.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
J. E. Castelao, R. D. Bart III, C. A. DiPerna, E. M. Sievers, and R. M. Bremner
Lung cancer and cyclooxygenase-2
Ann. Thorac. Surg., October 1, 2003; 76(4): 1327 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
I. Yakar, R. Melamed, G. Shakhar, K. Shakhar, E. Rosenne, N. Abudarham, G. G. Page, and S. Ben-Eliyahu
Prostaglandin E2 Suppresses NK Activity In Vivo and Promotes Postoperative Tumor Metastasis in Rats
Ann. Surg. Oncol., May 1, 2003; 10(4): 469 - 479.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. X. Zhu, S. Sharma, B. Gardner, B. Escuadro, K. Atianzar, D. P. Tashkin, and S. M. Dubinett
IL-10 Mediates Sigma1 Receptor-Dependent Suppression of Antitumor Immunity
J. Immunol., April 1, 2003; 170(7): 3585 - 3591.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Sharma, M. Stolina, S.-C. Yang, F. Baratelli, J. F. Lin, K. Atianzar, J. Luo, L. Zhu, Y. Lin, M. Huang, et al.
Tumor Cyclooxygenase 2-dependent Suppression of Dendritic Cell Function
Clin. Cancer Res., March 1, 2003; 9(3): 961 - 968.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Heuze-Vourc'h, L. Zhu, K. Krysan, R. K. Batra, S. Sharma, and S. M. Dubinett
Abnormal Interleukin 10R{alpha} Expression Contributes to the Maintenance of Elevated Cyclooxygenase-2 in Non-Small Cell Lung Cancer Cells
Cancer Res., February 15, 2003; 63(4): 766 - 770.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. K. Batra, Y. Lin, S. Sharma, M. Dohadwala, J. Luo, M. Pold, and S. M. Dubinett
Non-Small Cell Lung Cancer-derived Soluble Mediators Enhance Apoptosis in Activated T Lymphocytes through an I{kappa}B Kinase-dependent Mechanism
Cancer Res., February 1, 2003; 63(3): 642 - 646.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Dohadwala, R. K. Batra, J. Luo, Y. Lin, K. Krysan, M. Pold, S. Sharma, and S. M. Dubinett
Autocrine/Paracrine Prostaglandin E2 Production by Non-small Cell Lung Cancer Cells Regulates Matrix Metalloproteinase-2 and CD44 in Cyclooxygenase-2-dependent Invasion
J. Biol. Chem., December 20, 2002; 277(52): 50828 - 50833.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
I Y Rosenblum and A D Dayan
Carcinogenicity testing of IL-10: principles and practicalities
Human and Experimental Toxicology, July 1, 2002; 21(7): 347 - 358.
[Abstract] [PDF]

Home page
 Cancer Res.Home page
R. Dorsey, N. Kundu, Q. Yang, C. S. Tannenbaum, H. Sun, T. A. Hamilton, and A. M. Fulton
Immunotherapy with Interleukin-10 Depends on the CXC Chemokines Inducible Protein-10 and Monokine Induced by IFN-{gamma}
Cancer Res., May 1, 2002; 62(9): 2606 - 2610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
C. Vancheri, C. Mastruzzo, V. Tomaselli, M. A. Sortino, L. D'Amico, G. Bellistri, M. P. Pistorio, E. T. Salinaro, F. Palermo, A. Mistretta, et al.
Normal Human Lung Fibroblasts Differently Modulate Interleukin-10 and Interleukin-12 Production by Monocytes . Implications for an Altered Immune Response in Pulmonary Chronic Inflammation
Am. J. Respir. Cell Mol. Biol., November 1, 2001; 25(5): 592 - 599.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Kalinski, P. L. Vieira, J. H. N. Schuitemaker, E. C. de Jong, and M. L. Kapsenberg
Prostaglandin E2 is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer
Blood, June 1, 2001; 97(11): 3466 - 3469.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. X. Zhu, S. Sharma, M. Stolina, B. Gardner, M. D. Roth, D. P. Tashkin, and S. M. Dubinett
{Delta}-9-Tetrahydrocannabinol Inhibits Antitumor Immunity by a CB2 Receptor-Mediated, Cytokine-Dependent Pathway
J. Immunol., July 1, 2000; 165(1): 373 - 380.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. Pyeon, F. J. Diaz, and G. A. Splitter
Prostaglandin E2 Increases Bovine Leukemia Virus tax and pol mRNA Levels via Cyclooxygenase 2: Regulation by Interleukin-2, Interleukin-10, and Bovine Leukemia Virus
J. Virol., June 15, 2000; 74(12): 5740 - 5745.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. M. Dubinett, R. K. Batra, P. W. Miller, and S. Sharma
Tumor Antigens in Thoracic Malignancy
Am. J. Respir. Cell Mol. Biol., May 1, 2000; 22(5): 524 - 527.
[Full Text]

Home page
 FASEB J.Home page
R. ZEIDLER, M. CSANADY, O. GIRES, S. LANG, B. SCHMITT, and B. WOLLENBERG
Tumor cell-derived prostaglandin E2 inhibits monocyte function by interfering with CCR5 and Mac-1
FASEB J, April 1, 2000; 14(5): 661 - 668.
[Abstract] [Full Text]

Home page
 J. Immunol.Home page
M. Stolina, S. Sharma, Y. Lin, M. Dohadwala, B. Gardner, J. Luo, L. Zhu, M. Kronenberg, P. W. Miller, J. Portanova, et al.
Specific Inhibition of Cyclooxygenase 2 Restores Antitumor Reactivity by Altering the Balance of IL-10 and IL-12 Synthesis
J. Immunol., January 1, 2000; 164(1): 361 - 370.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Sharma, M. Stolina, Y. Lin, B. Gardner, P. W. Miller, M. Kronenberg, and S. M. Dubinett
T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function
J. Immunol., November 1, 1999; 163(9): 5020 - 5028.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
G. Bellone, A. Turletti, E. Artusio, K. Mareschi, A. Carbone, D. Tibaudi, A. Robecchi, G. Emanuelli, and U. Rodeck
Tumor-Associated Transforming Growth Factor-{beta} and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients
Am. J. Pathol., August 1, 1999; 155(2): 537 - 547.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B. K. Halak, H. C. Maguire Jr., and E. C. Lattime
Tumor-induced Interleukin-10 Inhibits Type 1 Immune Responses Directed at a Tumor Antigen As Well As a Non-Tumor Antigen Present at the Tumor Site
Cancer Res., February 1, 1999; 59(4): 911 - 917.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
A. Hagenbaugh, S. Sharma, S. M. Dubinett, S. H.-Y. Wei, R. Aranda, H. Cheroutre, D. J. Fowell, S. Binder, B. Tsao, R. M. Locksley, et al.
Altered Immune Responses in Interleukin 10 Transgenic Mice
J. Exp. Med., June 16, 1997; 185(12): 2101 - 2110.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Dohadwala, J. Luo, L. Zhu, Y. Lin, G. J. Dougherty, S. Sharma, M. Huang, M. Pold, R. K. Batra, and S. M. Dubinett
Non-small Cell Lung Cancer Cyclooxygenase-2-dependent Invasion Is Mediated by CD44
J. Biol. Chem., June 8, 2001; 276(24): 20809 - 20812.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1996 by The American Association of Immunologists, Inc. All rights reserved.