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The Journal of Immunology, Vol 157, Issue 10 4602-4608, Copyright © 1996 by American Association of Immunologists
ARTICLES |
SW Chensue, KS Warmington, JH Ruth, PS Sanghi, P Lincoln and SL Kunkel
Department of Pathology, Veterans Affairs Medical Center, Ann Arbor, MI 48105, USA.
The present study examined the contribution of monocyte chemotactic protein-1 (MCP-1) to granulomatous inflammation mediated by Th1- and Th2-related cytokines. Types 1 and 2 lung granulomas (GR) were respectively induced in presensitized CBA mice by embolization of beads coupled to purified protein derivative of Mycobacteria tuberculosis or soluble Ags derived from Schistosoma mansoni eggs. MCP-1 was spontaneously produced by intact GR, isolated GR macrophages, and draining lymph node cultures, but levels were greater in the type 2 than in the type 1 response. In vivo depletion of IFN-gamma augmented type 2 inflammation and local MCP production; IL-4 depletion had the opposite effect. These treatments had no significant effect on the type 1 response. Treatment with anti-MCP-1, but not that with anti-MIP- 1alpha, Abs caused a 30% decrease in type 2 GR area. Neither treatment affected the type 1 GR. Intrinsic MCP-1 was detected immunohistochemically within lymph nodes and appeared to support IL-4- /IL-5-producing lymph node cells. In addition, MCP-1 inhibited IL-12 production by inflammatory macrophages. The latter was demonstrated as a potentially direct effect of MCP-1 on macrophages. These findings show that MCP-1 contributes more to type 2 than to type 1 cytokine- mediated inflammation and suggest a broader role for chemokines in regulating Th cell expression.
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C. M. Hogaboam, C. L. Bone-Larson, S. Lipinski, N. W. Lukacs, S. W. Chensue, R. M. Strieter, and S. L. Kunkel Differential Monocyte Chemoattractant Protein-1 and Chemokine Receptor 2 Expression by Murine Lung Fibroblasts Derived from Th1- and Th2-Type Pulmonary Granuloma Models J. Immunol., August 15, 1999; 163(4): 2193 - 2201. [Abstract] [Full Text] [PDF]
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K. S. Warmington, L. Boring, J. H. Ruth, J. Sonstein, C. M. Hogaboam, J. L. Curtis, S. L. Kunkel, I. R. Charo, and S. W. Chensue Effect of C-C Chemokine Receptor 2 (CCR2) Knockout on Type-2 (Schistosomal Antigen-Elicited) Pulmonary Granuloma Formation : Analysis of Cellular Recruitment and Cytokine Responses Am. J. Pathol., May 1, 1999; 154(5): 1407 - 1416. [Abstract] [Full Text] [PDF]
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J. W. Lillard Jr., P. N. Boyaka, J. A. Hedrick, A. Zlotnik, and J. R. McGhee Lymphotactin Acts as an Innate Mucosal Adjuvant J. Immunol., February 15, 1999; 162(4): 1959 - 1965. [Abstract] [Full Text] [PDF]
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J. Huang, M.-D. Wang, S. Lenz, D. Gao, and B. Kaltenboeck IL-12 Administered During Chlamydia psittaci Lung Infection in Mice Confers Immediate and Long-Term Protection and Reduces Macrophage Inflammatory Protein-2 Level and Neutrophil Infiltration in Lung Tissue J. Immunol., February 15, 1999; 162(4): 2217 - 2226. [Abstract] [Full Text] [PDF]
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J. H. Ruth, N. W. Lukacs, K. S. Warmington, T. J. Polak, M. Burdick, S. L. Kunkel, R. M. Strieter, and S. W. Chensue Expression and Participation of Eotaxin During Mycobacterial (Type 1) and Schistosomal (Type 2) Antigen-Elicited Granuloma Formation J. Immunol., October 15, 1998; 161(8): 4276 - 4282. [Abstract] [Full Text] [PDF]
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E. Rakasz, A. M. Blum, A. Metwali, D. E. Elliott, J. Li, Z. K. Ballas, K. Qadir, R. Lynch, and J. V. Weinstock Localization and Regulation of IFN-{gamma} Production Within the Granulomas of Murine Schistosomiasis in IL-4-Deficient and Control Mice J. Immunol., May 15, 1998; 160(10): 4994 - 4999. [Abstract] [Full Text] [PDF]
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Y. Lin, J. Gong, M. Zhang, W. Xue, and P. F. Barnes Production of Monocyte Chemoattractant Protein 1 in Tuberculosis Patients Infect. Immun., May 1, 1998; 66(5): 2319 - 2322. [Abstract] [Full Text] [PDF]
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P. Proost, S. Struyf, M. Couvreur, J.-P. Lenaerts, R. Conings, P. Menten, P. Verhaert, A. Wuyts, and J. V. Damme Posttranslational Modifications Affect the Activity of the Human Monocyte Chemotactic Proteins MCP-1 and MCP-2: Identification of MCP-2(6-76) as a Natural Chemokine Inhibitor J. Immunol., April 15, 1998; 160(8): 4034 - 4041. [Abstract] [Full Text] [PDF]
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W. J. Karpus, K. J. Kennedy, S. L. Kunkel, and N. W. Lukacs Monocyte Chemotactic Protein 1 Regulates Oral Tolerance Induction by Inhibition of T Helper Cell 1-related Cytokines J. Exp. Med., March 2, 1998; 187(5): 733 - 741. [Abstract] [Full Text] [PDF]
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B. Lu, B. J. Rutledge, L. Gu, J. Fiorillo, N. W. Lukacs, S. L. Kunkel, R. North, C. Gerard, and B. J. Rollins Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1-deficient Mice J. Exp. Med., February 16, 1998; 187(4): 601 - 608. [Abstract] [Full Text] [PDF]
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C. M. McManus, C. F. Brosnan, and J. W. Berman Cytokine Induction of MIP-1{alpha} and MIP-1{beta} in Human Fetal Microglia J. Immunol., February 1, 1998; 160(3): 1449 - 1455. [Abstract] [Full Text] [PDF]
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T. Kurihara, G. Warr, J. Loy, and R. Bravo Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor J. Exp. Med., November 17, 1997; 186(10): 1757 - 1762. [Abstract] [Full Text] [PDF]
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