| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 10 4371-4378, Copyright © 1996 by American Association of Immunologists
ARTICLES |
S Sato, N Ono, DA Steeber, DS Pisetsky and TF Tedder
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
CD19 serves as a cell surface response regulator that establishes signaling thresholds critical for B lymphocyte development and activation. B lymphocytes from CD19-deficient mice are hyporesponsive to transmembrane signals, while B lymphocytes from mice that overexpress CD19 to even a small extent (25% increase) become hyperresponsive. The B-1 subpopulation of B lymphocytes is particularly sensitive to CD19 regulation, since their development is severely decreased in CD19-deficient mice. The effect of altered CD19 expression levels on the development of B cells was therefore examined using transgenic mice that express varying levels of cell surface CD19. In this study, immature B cells within the bone marrow of wild-type mice were found to specifically up-regulate CD19 expression levels by twofold as they mature, while CD5+ B cells within the spleen and peritoneum expressed even higher levels of CD19. The development of CD5+ B cells was severely decreased in CD19-deficient mice, while there was a linear correlation between increased CD19 expression levels and the increased frequency of CD5+ B cells within the peritoneum and spleen. In fact, CD5+ B cells became a major B lymphocyte population in mice that overexpressed CD19. Increased expression of CD19 also correlated with increased levels of endogenous anti-DNA Abs and rheumatoid factor. These results indicate that up-regulated expression of CD19 is functionally important for B cell development and that CD19 establishes signaling thresholds that regulate the generation of B-1 lymphocytes as well as the development of autoantibodies.
This article has been cited by other articles:
|
|
 |
|
  V. Minard-Colin, Y. Xiu, J. C. Poe, M. Horikawa, C. M. Magro, Y. Hamaguchi, K. M. Haas, and T. F. Tedder Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage Fc{gamma}RI, Fc{gamma}RIII, and Fc{gamma}RIV Blood, August 15, 2008; 112(4): 1205 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yoshizaki, Y. Iwata, K. Komura, F. Ogawa, T. Hara, E. Muroi, M. Takenaka, K. Shimizu, M. Hasegawa, M. Fujimoto, et al. CD19 Regulates Skin and Lung Fibrosis via Toll-Like Receptor Signaling in a Model of Bleomycin-Induced Scleroderma Am. J. Pathol., June 1, 2008; 172(6): 1650 - 1663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Xiao, D.-m. Su, and N. R. Manley T Cell Development from Kit-Negative Progenitors in the Foxn1{Delta}/{Delta} Mutant Thymus J. Immunol., January 15, 2008; 180(2): 914 - 921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yanaba, Y. Hamaguchi, G. M. Venturi, D. A. Steeber, E. W. St. Clair, and T. F. Tedder B Cell Depletion Delays Collagen-Induced Arthritis in Mice: Arthritis Induction Requires Synergy between Humoral and Cell-Mediated Immunity J. Immunol., July 15, 2007; 179(2): 1369 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Kaminski and J. Stavnezer Antibody class switching differs among SJL, C57BL/6 and 129 mice Int. Immunol., April 1, 2007; 19(4): 545 - 556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shankar, J. C. Nixon, S. Maier, J. Workman, A. D. Farris, and C. F. Webb Anti-Nuclear Antibody Production and Autoimmunity in Transgenic Mice That Overexpress the Transcription Factor Bright J. Immunol., March 1, 2007; 178(5): 2996 - 3006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, Y. Hamaguchi, K. Yanaba, J.-D. Bouaziz, J. Uchida, M. Fujimoto, T. Matsushita, Y. Matsushita, M. Horikawa, K. Komura, et al. B-Lymphocyte Depletion Reduces Skin Fibrosis and Autoimmunity in the Tight-Skin Mouse Model for Systemic Sclerosis Am. J. Pathol., September 1, 2006; 169(3): 954 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nijnik, H. Ferry, G. Lewis, E. Rapsomaniki, J. C. H. Leung, A. Daser, T. Lambe, C. C. Goodnow, and R. J. Cornall Spontaneous B cell hyperactivity in autoimmune-prone MRL mice Int. Immunol., July 1, 2006; 18(7): 1127 - 1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ferry, T. L. Crockford, J. C. H. Leung, and R. J. Cornall Signals from a self-antigen induce positive selection in early B cell ontogeny but are tolerogenic in adults. J. Immunol., June 15, 2006; 176(12): 7402 - 7411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hamaguchi, Y. Xiu, K. Komura, F. Nimmerjahn, and T. F. Tedder Antibody isotype-specific engagement of Fc{gamma} receptors regulates B lymphocyte depletion during CD20 immunotherapy J. Exp. Med., March 20, 2006; 203(3): 743 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Lee, K. M. Haas, D. O. Gor, X. Ding, D. R. Karp, N. S. Greenspan, J. C. Poe, and T. F. Tedder Complement Component C3d-Antigen Complexes Can Either Augment or Inhibit B Lymphocyte Activation and Humoral Immunity in Mice Depending on the Degree of CD21/CD19 Complex Engagement J. Immunol., December 15, 2005; 175(12): 8011 - 8023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yazawa, Y. Hamaguchi, J. C. Poe, and T. F. Tedder Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease PNAS, October 18, 2005; 102(42): 15178 - 15183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yan, M. J. Wolff, J. Unternaehrer, I. Mellman, and M. J. Mamula Targeting antigen to CD19 on B cells efficiently activates T cells Int. Immunol., July 1, 2005; 17(7): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Hamaguchi, J. Uchida, D. W. Cain, G. M. Venturi, J. C. Poe, K. M. Haas, and T. F. Tedder The Peritoneal Cavity Provides a Protective Niche for B1 and Conventional B Lymphocytes during Anti-CD20 Immunotherapy in Mice J. Immunol., April 1, 2005; 174(7): 4389 - 4399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Grimaldi, R. Hicks, and B. Diamond B Cell Selection and Susceptibility to Autoimmunity J. Immunol., February 15, 2005; 174(4): 1775 - 1781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Moll, E. Martinez-Soria, M.-L. Santiago-Raber, H. Amano, M. Pihlgren-Bosch, D. Marinkovic, and S. Izui Differential Activation of Anti-Erythrocyte and Anti-DNA Autoreactive B Lymphocytes by the Yaa Mutation J. Immunol., January 15, 2005; 174(2): 702 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Uchida, Y. Hamaguchi, J. A. Oliver, J. V. Ravetch, J. C. Poe, K. M. Haas, and T. F. Tedder The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor-dependent Mechanisms during Anti-CD20 Antibody Immunotherapy J. Exp. Med., June 21, 2004; 199(12): 1659 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R J Looney, J Anolik, and I Sanz B lymphocytes in systemic lupus erythematosus: lessons from therapy targeting B cells Lupus, May 1, 2004; 13(5): 381 - 390. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Planque, Y. Bangale, X.-T. Song, S. Karle, H. Taguchi, B. Poindexter, R. Bick, A. Edmundson, Y. Nishiyama, and S. Paul Ontogeny of Proteolytic Immunity: IgM SERINE PROTEASES J. Biol. Chem., April 2, 2004; 279(14): 14024 - 14032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ferry, M. Jones, D. J. Vaux, I. S.D. Roberts, and R. J. Cornall The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells J. Exp. Med., November 3, 2003; 198(9): 1415 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shoham, R. Rajapaksa, C. Boucheix, E. Rubinstein, J. C. Poe, T. F. Tedder, and S. Levy The Tetraspanin CD81 Regulates the Expression of CD19 During B Cell Development in a Postendoplasmic Reticulum Compartment J. Immunol., October 15, 2003; 171(8): 4062 - 4072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Whyburn, K. E. Halcomb, C. M. Contreras, C. A. Lowell, O. N. Witte, and A. B. Satterthwaite Reduced Dosage of Bruton's Tyrosine Kinase Uncouples B Cell Hyperresponsiveness from Autoimmunity in lyn-/- Mice J. Immunol., August 15, 2003; 171(4): 1850 - 1858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yazawa, M. Fujimoto, S. Sato, K. Miyake, N. Asano, Y. Nagai, O. Takeuchi, K. Takeda, H. Okochi, S. Akira, et al. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes Blood, August 15, 2003; 102(4): 1374 - 1380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Amano, E. Amano, T. Moll, D. Marinkovic, N. Ibnou-Zekri, E. Martinez-Soria, I. Semac, T. Wirth, L. Nitschke, and S. Izui The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells J. Immunol., March 1, 2003; 170(5): 2293 - 2301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yasutomo Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus Rheumatology, February 1, 2003; 42(2): 214 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Marchbank, L. Kulik, M. G. Gipson, B. P. Morgan, and V. M. Holers Expression of Human Complement Receptor Type 2 (CD21) in Mice During Early B Cell Development Results in a Reduction in Mature B Cells and Hypogammaglobulinemia J. Immunol., October 1, 2002; 169(7): 3526 - 3535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, J. C. Poe, A. B. Satterthwaite, M. I. Wahl, O. N. Witte, and T. F. Tedder Complementary Roles for CD19 and Bruton's Tyrosine Kinase in B Lymphocyte Signal Transduction J. Immunol., June 1, 2002; 168(11): 5465 - 5476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shivtiel, N. Leider, O. Sadeh, Z. Kraiem, and D. Melamed Impaired Light Chain Allelic Exclusion and Lack of Positive Selection in Immature B Cells Expressing Incompetent Receptor Deficient of CD19 J. Immunol., June 1, 2002; 168(11): 5596 - 5604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lu, R. C. Axtell, J. F. Collawn, A. Gibson, L. B. Justement, and C. Raman AP2 Adaptor Complex-Dependent Internalization of CD5: Differential Regulation in T and B Cells J. Immunol., June 1, 2002; 168(11): 5612 - 5620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Gauld, J. M. Dal Porto, and J. C. Cambier B Cell Antigen Receptor Signaling: Roles in Cell Development and Disease Science, May 31, 2002; 296(5573): 1641 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Rothstein Two B-1 or Not To Be One J. Immunol., May 1, 2002; 168(9): 4257 - 4261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tiroch, B. Stockmeyer, C. Frank, and T. Valerius Intracellular Domains of Target Antigens Influence Their Capacity to Trigger Antibody-Dependent Cell-Mediated Cytotoxicity J. Immunol., April 1, 2002; 168(7): 3275 - 3282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Croker, D. M. Tarlinton, L. A. Cluse, A. J. Tuxen, A. Light, F.-C. Yang, D. A. Williams, and A. W. Roberts The Rac2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1a and Marginal Zone B Lymphocytes J. Immunol., April 1, 2002; 168(7): 3376 - 3386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inabe and T. Kurosaki Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement Blood, January 15, 2002; 99(2): 584 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. HASLER and M. ZOUALI B cell receptor signaling and autoimmunity FASEB J, October 1, 2001; 15(12): 2085 - 2098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, M. Fujimoto, J. C. Poe, D. A. Steeber, and T. F. Tedder CD19 Can Regulate B Lymphocyte Signal Transduction Independent of Complement Activation J. Immunol., September 15, 2001; 167(6): 3190 - 3200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hasegawa, M. Fujimoto, J. C. Poe, D. A. Steeber, C. A. Lowell, and T. F. Tedder A CD19-Dependent Signaling Pathway Regulates Autoimmunity in Lyn-Deficient Mice J. Immunol., September 1, 2001; 167(5): 2469 - 2478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Davidson and B. Diamond Autoimmune Diseases N. Engl. J. Med., August 2, 2001; 345(5): 340 - 350. [Full Text] [PDF]
|
|
|
|
|
|
G. A. Kingsbury, L. A. Feeney, Y. Nong, S. A Calandra, C. J. Murphy, J. M. Corcoran, Y. Wang, M. R. Prabhu Das, S. J. Busfield, C. C. Fraser, et al. Cloning, Expression, and Function of BLAME, a Novel Member of the CD2 Family J. Immunol., May 1, 2001; 166(9): 5675 - 5680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Wortis and R. Berland Cutting Edge Commentary: Origins of B-1 Cells J. Immunol., February 15, 2001; 166(4): 2163 - 2166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qian, C. Santiago, M. Borrero, T. F. Tedder, and S. H. Clarke Lupus-Specific Antiribonucleoprotein B Cell Tolerance in Nonautoimmune Mice Is Maintained by Differentiation to B-1 and Governed by B Cell Receptor Signaling Thresholds J. Immunol., February 15, 2001; 166(4): 2412 - 2419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sato, M. Hasegawa, M. Fujimoto, T. F. Tedder, and K. Takehara Quantitative Genetic Variation in CD19 Expression Correlates with Autoimmunity J. Immunol., December 1, 2000; 165(11): 6635 - 6643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Bobbitt and L. B. Justement Regulation of MHC Class II Signal Transduction by the B Cell Coreceptors CD19 and CD22 J. Immunol., November 15, 2000; 165(10): 5588 - 5596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Mary, C. Laporte, D. Parzy, M.-L. Santiago, F. Stefani, F. Lajaunias, R. M. E. Parkhouse, T. L. O'Keefe, M. S. Neuberger, S. Izui, et al. Cd22a PRE-mRNA Dysregulated Expression of the Cd22 Gene as a Result of a Short Interspersed Nucleotide Element Insertion in Cd22a Lupus-Prone Mice J. Immunol., September 15, 2000; 165(6): 2987 - 2996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ratanatharathorn, E. Carson, C. Reynolds, L. J. Ayash, J. Levine, G. Yanik, S. M. Silver, J. L.M. Ferrara, and J. P. Uberti Anti-CD20 Chimeric Monoclonal Antibody Treatment of Refractory Immune-Mediated Thrombocytopenia in a Patient with Chronic Graft-versus-Host Disease Ann Intern Med, August 15, 2000; 133(4): 275 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
, , , , , , , , , and Human Anti-Thyroid Peroxidase Single-Chain Fragment Variable of Ig Isolated from a Combinatorial Library Assembled In-Cell: Insights into the In Vivo J. Immunol., April 15, 2000; 164(8): 4162 - 4169. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. W. Arnold, S. K. McCray, C. Tatu, and S. H. Clarke Identification of a Precursor to Phosphatidyl Choline-Specific B-1 Cells Suggesting That B-1 Cells Differentiate from Splenic Conventional B Cells In Vivo: Cyclosporin A Blocks Differentiation to B-1 J. Immunol., March 15, 2000; 164(6): 2924 - 2930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Brooks, X. Li, E. J. Volanakis, and R. H. Carter Systematic Analysis of the Role of CD19 Cytoplasmic Tyrosines in Enhancement of Activation in Daudi Human B Cells: Clustering of Phospholipase C and Vav and of Grb2 and Sos with Different CD19 Tyrosines J. Immunol., March 15, 2000; 164(6): 3123 - 3131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Pan, S. Sato, J. P. Frederick, X.-H. Sun, and Y. Zhuang Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene Mol. Cell. Biol., September 1, 1999; 19(9): 5969 - 5980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Novelli, M. Ramírez, W. Leung, and C. I. Civin Human Hematopoietic Stem/Progenitor Cells Generate CD5+ B Lymphoid Cells in NOD/SCID Mice Stem Cells, September 1, 1999; 17(5): 242 - 252. [Abstract] [Full Text]
|
|
|
|
|
|
M. Fujimoto, J. C. Poe, P. J. Jansen, S. Sato, and T. F. Tedder CD19 Amplifies B Lymphocyte Signal Transduction by Regulating Src-Family Protein Tyrosine Kinase Activation J. Immunol., June 15, 1999; 162(12): 7088 - 7094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Vink, G. Warnier, F. Brombacher, and J.-C. Renauld Interleukin 9-induced In Vivo Expansion of the B-1 Lymphocyte Population J. Exp. Med., May 3, 1999; 189(9): 1413 - 1423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A N Theofilopoulos Effector and predisposing genes in murine lupus Lupus, November 1, 1998; 7(9): 575 - 584. [Abstract] [PDF]
|
|
|
|
|
|
T. Fehr, R. C. Rickert, B. Odermatt, J. Roes, K. Rajewsky, H. Hengartner, and R. M. Zinkernagel Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19 J. Exp. Med., July 1, 1998; 188(1): 145 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Clarke and L. W. Arnold B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation J. Exp. Med., April 20, 1998; 187(8): 1325 - 1334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Buhl, C. M. Pleiman, R. C. Rickert, and J. C. Cambier Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization J. Exp. Med., December 1, 1997; 186(11): 1897 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. N. Tsitsikov, J. C. Gutierrez-Ramos, and R. S. Geha Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice PNAS, September 30, 1997; 94(20): 10844 - 10849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-K. Somani, K. Yuen, F. Xu, J. Zhang, D. R. Branch, and K. A. Siminovitch The SH2 Domain Containing Tyrosine Phosphatase-1 Down-regulates Activation of Lyn and Lyn-induced Tyrosine Phosphorylation of the CD19 Receptor in B Cells J. Biol. Chem., January 12, 2001; 276(3): 1938 - 1944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujimoto, J. C. Poe, M. Hasegawa, and T. F. Tedder CD19 Amplification of B Lymphocyte Ca2+ Responses. A ROLE FOR Lyn SEQUESTRATION IN EXTINGUISHING NEGATIVE REGULATION J. Biol. Chem., November 21, 2001; 276(48): 44820 - 44827. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
