| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 157, Issue 10 4363-4370, Copyright © 1996 by American Association of Immunologists
ARTICLES |
LM Pinchuk, SJ Klaus, DM Magaletti, GV Pinchuk, JP Norsen and EA Clark
Regional Primate Research Center, University of Washington Medical Center, Seattle 98195, USA.
We examined whether human blood dendritic cells (DCs) express a functional ligand for CD40 (CD40L). Human blood DCs expressed significant amounts of cell surface CD40L identical to that expressed on activated T cells, as detected by mAb to CD40L or a chimeric CD40.Ig fusion protein (CD40.Ig). Stimulation through CD40 up-regulated protein and mRNA CD40L expression in DCs, B cells, and B cell lines. CD40- mediated CD40L expression was inhibited by a protein tyrosine kinase inhibitor, herbimycin, in a dose-dependent manner, suggesting that the induction of CD40L expression via CD40 requires protein tyrosine kinase activity. CD40L surface expression correlated with constitutive or inducible levels of CD40L-specific mRNA, as determined by reverse transcribed PCR analysis (RT-PCR) using CD40L-homologous primers. Furthermore, CD40L on DCs was functional, since CD40L+ DCs, unlike CD40L- DCs, induced B cell IgG and IgA production, and this induction could be inhibited by blocking CD40L-CD40 interactions with mAb to CD40L. Thus, CD40L on DCs and CD40L induced by crosslinking CD40 may regulate B cell activation and maturation. The importance of DC CD40L expression on B cell function is discussed.
This article has been cited by other articles:
|
|
 |
|
  L. Santos, K. E. Draves, M. Boton, P. K. Grewal, J. D. Marth, and E. A. Clark Dendritic Cell-Dependent Inhibition of B Cell Proliferation Requires CD22 J. Immunol., April 1, 2008; 180(7): 4561 - 4569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Thusberg and M. Vihinen The structural basis of hyper IgM deficiency - CD40L mutations Protein Eng. Des. Sel., March 1, 2007; 20(3): 133 - 141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Pham, A. T. Tamayo, L. C. Yoshimura, Y.-C. Lin-Lee, and R. J. Ford Constitutive NF-{kappa}B and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival Blood, December 1, 2005; 106(12): 3940 - 3947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Mascarell, C. Fayolle, C. Bauche, D. Ladant, and C. Leclerc Induction of Neutralizing Antibodies and Th1-Polarized and CD4-Independent CD8+ T-Cell Responses following Delivery of Human Immunodeficiency Virus Type 1 Tat Protein by Recombinant Adenylate Cyclase of Bordetella pertussis J. Virol., August 1, 2005; 79(15): 9872 - 9884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-C. Chen, H.-W. Chang, C.-J. Wu, C.-H. Yang, W. C. Hung, K.-H. Yeh, and M. Fu Percutaneous Transluminal Mitral Valvuloplasty Reduces Circulating Soluble CD40 Ligand in Rheumatic Mitral Stenosis Chest, July 1, 2005; 128(1): 36 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Quah, K. Ni, and H. C. O'Neill In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity Int. Immunol., April 1, 2004; 16(4): 567 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kaufman, P. J. Sime, and R. P. Phipps Expression of CD154 (CD40 Ligand) by Human Lung Fibroblasts: Differential Regulation by IFN-{gamma} and IL-13, and Implications for Fibrosis J. Immunol., February 1, 2004; 172(3): 1862 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. O. Lee, J. Moyron-Quiroz, J. Rangel-Moreno, K. L. Kusser, L. Hartson, F. Sprague, F. E. Lund, and T. D. Randall CD40, but Not CD154, Expression on B Cells Is Necessary for Optimal Primary B Cell Responses J. Immunol., December 1, 2003; 171(11): 5707 - 5717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Gelbmann, S N Leeb, D Vogl, M Maendel, H Herfarth, J Scholmerich, W Falk, and G Rogler Inducible CD40 expression mediates NF{kappa}B activation and cytokine secretion in human colonic fibroblasts Gut, October 1, 2003; 52(10): 1448 - 1456. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Fillatreau and D. Gray T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation J. Exp. Med., January 20, 2003; 197(2): 195 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Manoj, P. J. Griebel, L. A. Babiuk, and S. van Drunen Littel-van den Hurk Targeting with Bovine CD154 Enhances Humoral Immune Responses Induced by a DNA Vaccine in Sheep J. Immunol., January 15, 2003; 170(2): 989 - 996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Bajer, D. Garcia-Tapia, K. R. Jordan, K. M. Haas, D. Werling, C. J. Howard, and D. M. Estes Peripheral blood-derived bovine dendritic cells promote IgG1-restricted B cell responses in vitro J. Leukoc. Biol., January 1, 2003; 73(1): 100 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Luft, M. Jefford, P. Luetjens, H. Hochrein, K.-A. Masterman, C. Maliszewski, K. Shortman, J. Cebon, and E. Maraskovsky IL-1{beta} Enhances CD40 Ligand-Mediated Cytokine Secretion by Human Dendritic Cells (DC): A Mechanism for T Cell-Independent DC Activation J. Immunol., January 15, 2002; 168(2): 713 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Schonbeck and P. Libby CD40 Signaling and Plaque Instability Circ. Res., December 7, 2001; 89(12): 1092 - 1103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. G. O'Gorman, B. DuChateau, M. Paniagua, J. Hunt, N. Bensen, and R. Yogev Abnormal CD40 Ligand (CD154) Expression in Human Immunodeficiency Virus-Infected Children Clin. Vaccine Immunol., November 1, 2001; 8(6): 1104 - 1109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Takahashi, A. Kenji, T. Norihiro, K. Eisaku, O. Takashi, H. Kazuhiko, Y. Tadashi, and A. Tadaatsu Morphological Interactions of Interdigitating Dendritic Cells with B and T Cells in Human Mesenteric Lymph Nodes Am. J. Pathol., July 1, 2001; 159(1): 131 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tone, Y. Tone, P. J. Fairchild, M. Wykes, and H. Waldmann Regulation of CD40 function by its isoforms generated through alternative splicing PNAS, February 13, 2001; 98(4): 1751 - 1756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages Int. Immunol., February 1, 2001; 13(2): 167 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Nagayama, K. Sato, H. Kawasaki, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, S. Asano, and T. A. Takahashi IL-12 Responsiveness and Expression of IL-12 Receptor in Human Peripheral Blood Monocyte-Derived Dendritic Cells J. Immunol., July 1, 2000; 165(1): 59 - 66. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Szomolanyi-Tsuda, J. D. Brien, J. E. Dorgan, R. M. Welsh, and R. L. Garcea The Role of CD40-CD154 Interaction in Antiviral T Cell-Independent IgG Responses J. Immunol., June 1, 2000; 164(11): 5877 - 5882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, H. Kawasaki, H. Nagayama, M. Enomoto, C. Morimoto, K. Tadokoro, T. Juji, and T. A. Takahashi TGF-{beta}1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors J. Immunol., March 1, 2000; 164(5): 2285 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Grammer, R. D. McFarland, J. Heaney, B. F. Darnell, and P. E. Lipsky Expression, Regulation, and Function of B Cell-Expressed CD154 in Germinal Centers J. Immunol., October 15, 1999; 163(8): 4150 - 4159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yin, L. Zhang, R. Wang, L. Radvanyi, C. Haudenschild, Q. Fang, M. R. Kehry, and Y. Shi Ligation of CD28 In Vivo Induces CD40 Ligand Expression and Promotes B Cell Survival J. Immunol., October 15, 1999; 163(8): 4328 - 4334. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Posner, L. A. Cavacini, M. P. Upton, K. C. Tillman, E. R. Gornstein, and C. M. Norris Jr. Surface Membrane-expressed CD40 Is Present on Tumor Cells from Squamous Cell Cancer of the Head and Neck in Vitro and in Vivo and Regulates Cell Growth in Tumor Cell Lines Clin. Cancer Res., August 1, 1999; 5(8): 2261 - 2270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yamane, T. Kato, and H. Nariuchi Effective Stimulation for IL-12 p35 mRNA Accumulation and Bioactive IL-12 Production of Antigen-Presenting Cells Interacted with Th Cells J. Immunol., June 1, 1999; 162(11): 6433 - 6441. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, H. Nagayama, K. Tadokoro, T. Juji, and T. A. Takahashi Extracellular Signal-Regulated Kinase, Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase, and p38mapk Are Involved in IL-10-Mediated Selective Repression of TNF-{alpha}-Induced Activation and Maturation of Human Peripheral Blood Monocyte-Derived Dendritic Cells J. Immunol., April 1, 1999; 162(7): 3865 - 3872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dubois, C. Barthelemy, I. Durand, Y.-J. Liu, C. Caux, and F. Briere Toward a Role of Dendritic Cells in the Germinal Center Reaction: Triggering of B Cell Proliferation and Isotype Switching J. Immunol., March 15, 1999; 162(6): 3428 - 3436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sato, H. Kawasaki, H. Nagayama, R. Serizawa, J. Ikeda, C. Morimoto, K. Yasunaga, N. Yamaji, K. Tadokoro, T. Juji, et al. CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells Blood, January 1, 1999; 93(1): 34 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zan, A. Cerutti, P. Dramitinos, A. Schaffer, and P. Casali CD40 Engagement Triggers Switching to IgA1 and IgA2 in Human B Cells Through Induction of Endogenous TGF-{beta}: Evidence for TGF-{beta} But Not IL-10-Dependent Direct S{micro}->S{alpha} and Sequential S{micro}->S{gamma}, S{gamma}->S{alpha} DNA Recombination J. Immunol., November 15, 1998; 161(10): 5217 - 5225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Craxton, G. Shu, J. D. Graves, J. Saklatvala, E. G. Krebs, and E. A. Clark p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes J. Immunol., October 1, 1998; 161(7): 3225 - 3236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dubois, C. Massacrier, B. Vanbervliet, J. Fayette, F. Briere, J. Banchereau, and C. Caux Critical Role of IL-12 in Dendritic Cell-Induced Differentiation of Naive B Lymphocytes J. Immunol., September 1, 1998; 161(5): 2223 - 2231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wykes, A. Pombo, C. Jenkins, and G. G. MacPherson Dendritic Cells Interact Directly with Naive B Lymphocytes to Transfer Antigen and Initiate Class Switching in a Primary T-Dependent Response J. Immunol., August 1, 1998; 161(3): 1313 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Moses, J. Nelson, and G. C. Bagby Jr The Influence of Human Immunodeficiency Virus-1 on Hematopoiesis Blood, March 1, 1998; 91(5): 1479 - 1495. [Full Text] [PDF]
|
|
|
|
|
|
N. Kushnir, L. Liu, and G. G. MacPherson Dendritic Cells and Resting B Cells Form Clusters In Vitro and In Vivo: T Cell Independence, Partial LFA-1 Dependence, and Regulation by Cross-Linking Surface Molecules J. Immunol., February 15, 1998; 160(4): 1774 - 1781. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Clark Regulation of B Lymphocytes by Dendritic Cells J. Exp. Med., March 3, 1997; 185(5): 801 - 804. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
