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The Journal of Immunology, Vol 157, Issue 10 4347-4353, Copyright © 1996 by American Association of Immunologists

ARTICLES

CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis

M Nishio, J Spielman, RK Lee, DL Nelson and ER Podack
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA.

Overexpression of B7 and intracellular adhesion molecule-1 (ICAM-1) on syngeneic cells triggered MHC-unrestricted lysis by MHC-restricted CD8+ CTL without TCR/CD3 engagement. Both CD28/B7 and LFA-1/ICAM-1 interactions were required for MHC-nonrestricted cytotoxicity. Cytotoxicity was measured in 4-h and 16- to 18-h cytotoxicity assays. B7-ICAM-1 overexpression triggered perforin- and Fas ligand-mediated lysis, while TNF-alpha was not elicited in MHC-unrestricted cytotoxicity. These results suggest that target cells may elicit MHC- unrestricted lysis from CTL through up-regulation of membrane adherence and costimulatory receptors.


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